Alterations in macrophage G proteins are associated with endotoxin tolerance

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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LIGAND: A versatile computerized approach for characterization of ligand-binding systems

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G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

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G proteins and dual control of adenylate cyclase

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G proteins

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Multiple Organ Failure

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Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.

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Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.

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Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

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A labile transcriptional repressor modulates endotoxin tolerance.

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Endotoxin tolerance is not a LPS-specific phenomenon: partial mimicry with IL-1, IL-10 and TGFβ

1994 • 101 citations

Light-based detection of biomolecules

1990 • 94 citations

CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis.

1993 • 78 citations

INCREASED NITRIC OXIDE SYNTHESIS DURING THE DEVELOPMENT OF ENDOTOXIN TOLERANCE

1995 • 77 citations

Suppression of TNF-alpha mRNA expression in LPS-primed macrophages occurs at the level of nuclear factor-kappa B activation, but not at the level of protein kinase C or CD14 expression.

1995 • 75 citations

Gi down-regulation as a mechanism for heterologous desensitization in adipocytes.

1992 • 72 citations

Pertussis toxin-sensitive factor differentially regulates lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production in mouse peritoneal macrophages.

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Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.

1994 • 65 citations

Desensitization of Macrophages to Endotoxin Effects Is Not Correlated with a Down-Regulation of Lipopolysaccharide-Binding Sites

1993 • 58 citations

Characterization and Use of Crude α-Subunit Preparations for Quantitative Immunoblotting of G Proteins

1994 • 48 citations

Involvement of a pertussis toxin-sensitive G-protein-coupled phospholipase A2 in lipopolysaccharide-stimulated prostaglandin E2 synthesis in cultured rat mesangial cells

1988 • 45 citations

Endotoxin tolerance is associated with altered GTP-binding protein function

1992 • 43 citations

In vivo inhibition of lipopolysaccharide-induced lethality and tumor necrosis factor synthesis by Rhodobacter sphaeroides diphosphoryl lipid A is dependent on corticosterone induction

1992 • 40 citations

G protein subunit interactions

1989 • 39 citations

Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance

1990 • 30 citations

The Role of Endotoxin during Typhoid Fever and Tularemia in Man. II. Altered Cardiovascular Responses to Catecholamines*

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Differential alteration of lipoxygenase and cyclooxygenase metabolism by rat peritoneal macrophages induced by endotoxin tolerance

1986 • 29 citations

Stability of the heart rate power spectrum over time in the conscious dog

1989 • 27 citations

Reduced G protein function in desensitized rat aorta.

1991 • 19 citations

Endotoxin Tolerance Differentially Alters Hemodynamic Responses to a Thromboxane A2 Mimetic and Phenylephrine

1991 • 17 citations

Altered macrophage function in tumor necrosis factor α- and endotoxin-induced tolerance

1995 • 15 citations

Endotoxin-tolerant rats are still protected from oxygen toxicity by low-dose endotoxin treatment

1985 • 12 citations

RELATION OF THE RETICULO-ENDOTHELIAL SYSTEM TO NATURAL AND ACQUIRED RESISTANCE IN SHOCK

1964 • 11 citations

Cross-tolerance between bacterial endotoxin and group B Streptococcus in neonatal rats

1994 • 5 citations