Transforming Growth Factor β 1 Potently Activates CPP32-like Proteases in Human Hepatoma Cells

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

The role of proteases during apoptosis

1996 • 558 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Nuclear changes in apoptosis

1995 • 538 citations

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.

1997 • 439 citations

Transforming growth factors and the regulation of cell proliferation

1990 • 390 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

The cell-death machine

1996 • 351 citations

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

1993 • 276 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

1997 • 243 citations

In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1.

1992 • 190 citations

Induction of apoptosis by transforming growth factor-β1 in the rat hepatoma cell line MCA-RH7777: A possible association with tissue transglutaminase expression

1993 • 113 citations

Processing/activation of CPP32-like proteases is involved in transforming growth factor ?1-induced apoptosis in rat hepatocytes

1997 • 88 citations

Apoptosis: lessons from in vitro systems

1995 • 87 citations

Characterization of apoptosis induced by transforming growth factor beta 1 in human hepatoma cells.

1994 • 42 citations

Induction of Apoptosis by Sphingosine-1-Phosphate in Human Hepatoma Cells Is Associated with Enhanced Expression of bax Gene Product

1996 • 38 citations

Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death?

1993 • 10 citations