Crystal Structures of Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Isoquinolinesulfonyl Protein Kinase Inhibitors H7, H8, and H89

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

1986 • 581 citations

Crystallographic refinement by simulated annealing

1988 • 411 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Three protein kinase structures define a common motif

1994 • 364 citations

2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1993 • 356 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

1995 • 273 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

1995 • 187 citations

The glycine-rich sequence of protein kinases: a multifunctional element

1994 • 165 citations

Mg X ATP2-dependent interaction of the inhibitor protein of the cAMP-dependent protein kinase with the catalytic subunit.

1983 • 159 citations

Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.

1994 • 151 citations

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

1995 • 148 citations

Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments

1992 • 142 citations

Domain movements in protein kinases

1994 • 129 citations

Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit.

1994 • 122 citations

Protein kinases — structure and function

1995 • 119 citations

Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states

1993 • 103 citations

Protein kinase regulation: insights from crystal structure analysis

1994 • 100 citations

Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of magnesium-ATP on protein-protein interactions

1993 • 92 citations

Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.

1993 • 87 citations

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: a new fluorescence displacement titration technique for characterizing the nucleotide binding site on the catalytic subunit

1983 • 75 citations

2.0 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent

1993 • 73 citations

Affinity Purification of the Cα and Cβ Isoforms of the Catalytic Subunit of cAMP-dependent Protein Kinase

1989 • 63 citations

K252a is a potent and selective inhibitor of phosphorylase kinase

1990 • 63 citations

Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.

1987 • 61 citations

Protein kinases

1994 • 60 citations

Protein kinase A inhibitors enhance radiation‐induced apoptosis

1995 • 54 citations

Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites

1994 • 51 citations

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: nucleotide binding to the chemically modified catalytic subunit

1984 • 37 citations

Role of protein phosphorylation and dephosphorylation in activation and desensitization of the cAMP-dependent Na+/H+ antiport.

1993 • 34 citations

Analysis by mutagenesis of the ATP binding site of the .gamma. subunit of skeletal muscle phosphorylase kinase expressed using a baculovirus system

1992 • 27 citations

Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase

1993 • 25 citations

Cloning of the Cα catalytic subunit of the bovine cAMP-dependent protein kinase

1992 • 23 citations

Adenosine cyclic 3',5'-monophosphate-dependent protein kinase: Interaction of the catalytic subunit and holoenzyme with lin-benzoadenine nucleotides

1983 • 17 citations

Induction by some protein kinase inhibitors of differentiation of a mouse megakaryoblastic cell line established by coinfection with Abelson murine leukemia virus and recombinant SV40 retrovirus.

1991 • 15 citations

Interaction of guanosine cyclic 3',5'-phosphate dependent protein kinase with lin-benzoadenine nucleotides

1985 • 12 citations

THE PROTEIN-KINASE-C INHIBITOR H7 BLOCKS NORMAL HUMAN LYMPHOCYTE STIMULATION AND INDUCES APOPTOSIS OF BOTH NORMAL LYMPHOCYTES AND LEUKEMIA MOLT-4 CELLS

1993 • 7 citations

H7, an inhibitor of protein kinase C, inhibits tumour cell division in mice bearing ascitic Ehrlich's carcinoma

1994 • 4 citations