Protein kinases — structure and function

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Three protein kinase structures define a common motif

1994 • 364 citations

cdc2 phosphorylation is required for its interaction with cyclin.

1991 • 338 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

1994 • 279 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

1995 • 187 citations

The glycine-rich sequence of protein kinases: a multifunctional element

1994 • 165 citations

A Newly Synthesized Selective Casein Kinase I Inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and Affinity Purification of Casein Kinase I from Bovine Testis

1989 • 163 citations

Intrasteric regulation of protein kinases and phosphatases

1991 • 151 citations

Domain movements in protein kinases

1994 • 129 citations

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

1995 • 123 citations

Protein kinase regulation: insights from crystal structure analysis

1994 • 100 citations

Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation.

1992 • 98 citations

Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies

1987 • 76 citations

Divalent metal ions influence catalysis and active‐site accessibility in the camp‐dependent protein kinase

1993 • 64 citations

Protein kinases

1994 • 60 citations

Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase.

1993 • 47 citations

Isotope partitioning in the adenosine 3',5'-monophosphate dependent protein kinase reaction indicates a steady-state random kinetic mechanism

1988 • 46 citations

Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.

1994 • 45 citations

The first structure of a receptor tyrosine kinase domain:a further step in understanding the molecular basis of insulin action

1995 • 27 citations

Holoenzyme interaction sites in the cAMP-dependent protein kinase. Histidine 87 in the catalytic subunit complements serine 99 in the type I regulatory subunit.

1994 • 14 citations