Distinction of Endocervical and Endometrial Adenocarcinomas

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Improved Amplification of Genital Human Papillomaviruses

2000 • 1,137 citations

Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri

2001 • 1,025 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Expression Status of p16 Protein Is Associated with Human Papillomavirus Oncogenic Potential in Cervical and Genital Lesions

1998 • 584 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Ki-67, Cyclin E, and p16 INK4 Are Complimentary Surrogate Biomarkers for Human Papilloma Virus-Related Cervical Neoplasia

2001 • 437 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

1994 • 370 citations

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

1996 • 362 citations

Prevalence of Human Papillomavirus DNA in Different Histological Subtypes of Cervical Adenocarcinoma

2000 • 333 citations

Clear cell carcinoma of the endometrium is characterized by a distinctive profile of p53, Ki-67, estrogen, and progesterone receptor expression

1998 • 223 citations

p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrepTM smears

2002 • 205 citations

A Panel of Immunohistochemical Stains, Including Carcinoembryonic Antigen, Vimentin, and Estrogen Receptor, Aids the Distinction Between Primary Endometrial and Endocervical Adenocarcinomas

2002 • 190 citations

The role of human papillomavirus in cervical adenocarcinoma carcinogenesis

2001 • 189 citations

p16INK4a Is a Useful Marker for the Diagnosis of Adenocarcinoma of the Cervix Uteri and Its Precursors

2003 • 183 citations

Distinction Between Endometrial and Endocervical Adenocarcinoma: An Immunohistochemical Study

2002 • 162 citations

Overexpression of the p16 Cell Cycle Inhibitor in Breast Cancer is Associated with a More Malignant Phenotype

2001 • 155 citations

Human papillomaviruses, expression of p16INK4A, and early endocervical glandular neoplasia

2002 • 127 citations

Comparison of estrogen and progesterone receptor, Ki-67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated cell differentiation

1998 • 124 citations

Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis.

2000 • 119 citations

Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas

2001 • 115 citations

Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation

1997 • 113 citations

Hormone Receptor Immunohistochemistry and Human Papillomavirus In Situ Hybridization Are Useful for Distinguishing Endocervical and Endometrial Adenocarcinomas

2002 • 111 citations

Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis

2002 • 107 citations

Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia

2002 • 107 citations

Glandular Lesions of the Uterine Cervix

2000 • 103 citations

Alteration of p16 and p15 genes in human uterine tumours

1999 • 97 citations

Human papillomavirus DNA in uterine cervix squamous cell carcinoma and adenocarcinoma detected by polymerase chain reaction

1996 • 88 citations

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

2000 • 88 citations

The immunohistochemical discrimination of endometrioid adenocarcinomas

1996 • 87 citations

Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups

2000 • 85 citations

Methylation of p16 in primary gynecologic malignancy

1999 • 79 citations

Immunohistochemical p16INK4a Analysis of Archival Tumors with Deletion, Hypermethylation, or Mutation of the CDKN2/MTS1 Gene

2000 • 60 citations

Expression of cell-cycle regulatory proteins in endometrial carcinomas: correlations with hormone receptor status and clinicopathologic parameters

2001 • 60 citations

Human Papillomavirus Types 16 and 18 Infection in Infiltrating Adenocarcinoma of the Cervix:PCR Analysis of 138 Cases and Correlation With Histologic Type and Grade

1996 • 60 citations

P16/MTS1 and pRB expression in endometrial carcinomas

1999 • 59 citations

Immunohistochemical analysis of the expression of cdk4 and p16INK4 in human endometrioid-type endometrial carcinoma

1997 • 58 citations

The human papillomavirus status of invasive cervical adenocarcinoma: A clinicopathological and outcome analysis

1995 • 57 citations

Well-Differentiated Villoglandular Adenocarcinoma of the Uterine Cervix: Oncogene/Tumor Suppressor Gene Alterations and Human Papillomavirus Genotyping

2000 • 52 citations

Human papillomavirus and mixed epithelial tumors of the endometrium

1998 • 48 citations

Differences in HPV 16- and HPV 18 E6/E7 oncogene expression between in situ and invasive adenocarcinomas of the cervix uteri

2000 • 47 citations

p16andp15Alterations in Primary Gynecologic Malignancy

1997 • 44 citations

Association of human papillomavirus with malignant and premalignant lesions of the uterine endometrium

1995 • 44 citations

Alterations of the p16 (MTS1) Gene in Testicular, Ovarian, and Endometrial Malignancies

1995 • 41 citations

Absence ofp15andp16Gene Alterations in Primary Cervical Carcinoma Tissues and Cell Lines with Human Papillomavirus Infection

1998 • 39 citations

p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.

1996 • 35 citations

Adenocarcinoma of the cervix and adenocarcinoma of the endometrium: distinction with PCR‐mediated detection of HPV DNA

1997 • 33 citations

Abnormal Expression of Sex Steroid Receptors and Cell Cycle-Related Molecules in Adenocarcinoma in Situ of the Uterine Cervix

1999 • 26 citations

Human Papillomavirus-Positive Well-Differentiated Villoglandular Adenocarcinoma of the Uterine Cervix: A Case Report and Review of the Literature

2000 • 26 citations

Low frequency of CDKN2 mutation in endometrial carcinomas

1995 • 20 citations