Role of tumour necrosis factor and reactive oxygen intermediates in lipopolysaccharide-induced pulmonary oedema and lethality

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

1990 • 828 citations

State of the Art

1983 • 655 citations

Interleukin-8 (IL-8): The Major Neutrophil Chemotactic Factor in the Lung

1991 • 550 citations

Laboratory models of sepsis and septic shock

1990 • 539 citations

Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.

1991 • 452 citations

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.

1990 • 447 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Adult Respiratory Distress Syndrome in Patients with Severe Neutropenia

1986 • 381 citations

Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice.

1987 • 380 citations

Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits

1985 • 369 citations

Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.

1987 • 364 citations

Increased sheep lung vascular permeability caused by Escherichia coli endotoxin.

1979 • 362 citations

Tumor Necrosis Factor Causes Increased Pulmonary Permeability and Edema: Comparison to Septic Acute Lung Injury

1988 • 338 citations

Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration

1990 • 335 citations

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function.

1984 • 310 citations

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

1987 • 295 citations

Evidence for Tumor Necrosis Factor-induced Pulmonary Microvascular Injury After Intestinal Ischemia—Reperfusion Injury

1990 • 283 citations

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

1982 • 257 citations

A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

1988 • 241 citations

N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production

1992 • 238 citations

Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability

1989 • 168 citations

Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils.

1988 • 161 citations

The role of oxidant injury in tumor cell sensitivity to recombinant human tumor necrosis factor in vivo. Implications for mechanisms of action.

1989 • 133 citations

Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin

1987 • 118 citations

Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock.

1991 • 103 citations

Adult respiratory distress syndrome in pediatric patients. I. Clinical aspects, pathophysiology, pathology, and mechanisms of lung injury

1988 • 88 citations

Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers

1984 • 82 citations

Septic shock: treatment

1991 • 77 citations

Endotoxin-mediated pulmonary endothelial cell injury.

1986 • 75 citations

Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice.

1985 • 72 citations

Vascular hyperpermeability induced by tumor necrosis factor and its augmentation by IL-1 and IFN-gamma is inhibited by selective depletion of neutrophils with a monoclonal antibody.

1990 • 71 citations

The Role of Granulocytes in Endotoxin-induced Vascular Injury

1973 • 60 citations

Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats

1987 • 58 citations

Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose

1980 • 46 citations

Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-1 beta

1988 • 43 citations

Endotoxin-induced lung injury in rats: role of eicosanoids

1989 • 42 citations

Adult respiratory distress syndrome. A live E coli septic primate model.

1987 • 34 citations