X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunity

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Causes and consequences of microRNA dysregulation in cancer

2009 • 2,879 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

X-inactivation profile reveals extensive variability in X-linked gene expression in females

2005 • 1,968 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Restoration of p53 function leads to tumour regression in vivo

2007 • 1,723 citations

Wnt signalling and its impact on development and cancer

2008 • 1,518 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Multiple newly identified loci associated with prostate cancer susceptibility

2008 • 858 citations

X chromosomal abnormalities in basal-like human breast cancer

2006 • 838 citations

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

1996 • 767 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

Evidence for a prostate cancer susceptibility locus on the X chromosome.

1998 • 682 citations

Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

2007 • 393 citations

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

2007 • 384 citations

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

2008 • 372 citations

An X Chromosome Gene, WTX , Is Commonly Inactivated in Wilms Tumor

2007 • 330 citations

X-linked inheritance of Fanconi anemia complementation group B

2004 • 316 citations

FOXP3 Expression and Overall Survival in Breast Cancer

2009 • 293 citations

Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours

2000 • 272 citations

An investigation of the familial aspects of carcinoma of the prostate

1960 • 244 citations

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2

2007 • 242 citations

Correlation of mutations of the SH2D1A gene and Epstein-Barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease

2000 • 238 citations

Evidence of an X-linked or recessive genetic component to prostate cancer risk

1995 • 232 citations

Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis

1992 • 216 citations

Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate

2009 • 210 citations

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis

2008 • 191 citations

X-Chromosome Genetics and Human Cancer

2004 • 187 citations

Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes

2007 • 159 citations

Familial testicular cancer in Norway and southern Sweden

1996 • 127 citations

Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer

2009 • 110 citations

Simpson‐golabi‐behmel syndrome associated with renal dysplasia and embryonal tumor: Localization of the gene to Xqcen‐q21

1992 • 108 citations

Epstein--Barr Virus-Negative Boys With Non-Hodgkin Lymphoma Are Mutated in the Sh2D1A Gene, as Are Patients With X-Linked Lymphoproliferative Disease (XLP)

1999 • 105 citations

FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the Locus

2009 • 96 citations

X-chromosome inactivation analysis in a female carrier of FOXP3 mutation

2002 • 95 citations

Linkage analysis of 153 prostate cancer families over a 30-cM region containing the putative susceptibility locus HPCX.

1999 • 95 citations

A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease.

2000 • 94 citations

Functional inactivation of the WTX gene is not a frequent event in Wilms’ tumors

2008 • 71 citations

WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact

2009 • 64 citations

FAMILIAL BLADDER CANCER IN THE NATIONAL SWEDISH FAMILY CANCER DATABASE

2001 • 52 citations

Activating Transcription Factor 2 and c-Jun–Mediated Induction of FoxP3 for Experimental Therapy of Mammary Tumor in the Mouse

2009 • 38 citations

A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region

2005 • 34 citations

Documentation of burkitt lymphoma with t(8;14) (q24;q32) in x-linked lymphoproliferative disease

1992 • 32 citations

Confirmation of the prostate cancer susceptibility locus HPCX in a set of 104 German prostate cancer families

2002 • 32 citations

Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci

2004 • 30 citations

Evaluation of breast tumour sex chromatin (barr body) as an index of survival and response to pituitary ablation

1972 • 28 citations

A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer

2008 • 14 citations

[Familial bladder cancer].

1995 • 11 citations