Coronary Vascular Responsiveness to Adenosine Is Impaired Additively by Blockade of Nitric Oxide Synthesis and a Sulfonylurea

The design and analysis of clinical experiments

1986 • 4,401 citations

The Design and Analysis of Clinical Experiments.

1987 • 3,206 citations

Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

1995 • 455 citations

Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy.

1990 • 444 citations

Endothelium-dependent, flow-induced dilation of isolated coronary arterioles

1990 • 420 citations

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

1990 • 409 citations

Interaction of pressure- and flow-induced responses in porcine coronary resistance vessels

1991 • 386 citations

Endothelial Release of Nitric Oxide Contributes to the Vasodilator Effect of Adenosine in Humans

1995 • 234 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.

1993 • 233 citations

Endothelium-Removal Decreases Relaxations of Canine Coronary Arteries Caused by β-Adrenergic Agonists and Adenosine

1985 • 194 citations

Role of Nitric Oxide in the Coronary Microvascular Responses to Adenosine and Increased Metabolic Demand

1995 • 176 citations

Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation.

1991 • 163 citations

ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo

1992 • 163 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans

1994 • 144 citations

A₂‐purinoceptor‐mediated relaxation in the guinea‐pig coronary vasculature: a role for nitric oxide

1993 • 136 citations

Myocardial reactive hyperemia.

1975 • 127 citations

Sulfonylurea K _ATP Blockade in Type II Diabetes and Preconditioning in Cardiovascular Disease

1996 • 126 citations

Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs.

1993 • 124 citations

Endogenous adenosine mediates coronary vasodilation during exercise after K(ATP)+ channel blockade.

1995 • 108 citations

Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs

1992 • 107 citations

Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs.

1994 • 107 citations

Glibenclamide decreases basal coronary blood flow in anesthetized dogs

1992 • 106 citations

Inhibition of nitric oxide production aggravates myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis.

1994 • 103 citations

Importance of endothelium-derived nitric oxide in porcine coronary resistance arteries

1991 • 98 citations

Serum glibenclamide in diabetic patients, and influence of food on the kinetics and effects of glibenclamide

1980 • 94 citations

Pharmacokinetic and pharmacodynamic studies of glibenclamide in non‐ insulin dependent diabetes mellitus.

1990 • 91 citations

Glibenclamide attenuates adenosine-induced bradycardia and coronary vasodilatation

1991 • 86 citations

Arginine analogues inhibit responses mediated by ATP-sensitive K+ channels

1996 • 83 citations

Role of K+ ATP channels and adenosine in the regulation of coronary blood flow during exercise with normal and restricted coronary blood flow.

1996 • 76 citations

Contribution of nitric oxide to coronary vasodilation during hypercapnic acidosis

1995 • 74 citations

Analysis of P2-Purinoceptor Subtypes on the Smooth Muscle and Endothelium of Rabbit Coronary Artery

1994 • 54 citations

Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs

1991 • 47 citations

Coronary Reactive Hyperemia and Adenosine-lnduced Vasodilation Are Mediated Partially by a Glyburide-Sensitive Mechanism

1992 • 45 citations

Behaviour of glibenclamide on repeated administration to diabetic patients

1977 • 45 citations

Interindividual variation in the absorption of glibenclamide in man

1986 • 38 citations

Radioimmunoassay of Glibenclamide

1979 • 26 citations

Effect of Blockade of the ATP-Sensitive Potassium Channel on Metabolic Coronary Vasodilation in the Dog

1993 • 18 citations

Comparison of the pharmacokinetics and pharmacodynamics of two commercial products containing glibenclamide.

1989 • 15 citations

A system approach to pharmacodynamics II: Glyburide pharmacodynamics and estimation of optimal drug delivery

1988 • 12 citations

Chlorpropamide and glibenclamide serum concentrations in hospitalized patients.

1982 • 11 citations

Nonspecific inhibition of adenosine-activated K+ current by glibenclamide in guinea pig atrial myocytes

1996 • 10 citations

Bio-availability of three formulations of glibenclamide.

1989 • 4 citations