Sulfonylurea K _ATP Blockade in Type II Diabetes and Preconditioning in Cardiovascular Disease

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

CFTR as a cAMP-Dependent Regulator of Sodium Channels

1995 • 1,074 citations

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

1993 • 1,005 citations

A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results.

1970 • 987 citations

Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.

1992 • 961 citations

Preconditioning the human myocardium

1993 • 720 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features.

1990 • 605 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels

1990 • 600 citations

Previous Angina Alters In-Hospital Outcome in TIMI 4

1995 • 530 citations

Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker.

1994 • 476 citations

Prodromal Angina Limits Infarct Size

1995 • 413 citations

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

1990 • 409 citations

Protein kinase C. Its role in ischemic preconditioning in the rat.

1994 • 362 citations

Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias

1987 • 339 citations

Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K ⁺ Channel?

1995 • 293 citations

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

1994 • 272 citations

A ?second window of protection? or delayed preconditioning phenomenon: Future horizons for myocardial protection?

1995 • 257 citations

Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with adenosine A1-receptors.

1992 • 255 citations

Improved myocardial ischemic response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: A prospective study

1992 • 250 citations

Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.

1990 • 222 citations

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.

1989 • 203 citations

Ischemic preconditioning increases adenosine release and 5'-nucleotidase activity during myocardial ischemia and reperfusion in dogs. Implications for myocardial salvage.

1993 • 201 citations

Regulation of Ion Channels by ABC Transporters That Secrete ATP

1995 • 174 citations

Adenosine and the anti-infarct effects of preconditioning

1993 • 160 citations

A Summary of Criticisms of the Findings and Conclusions of the University Group Diabetes Program (UGDP)

1972 • 151 citations

Preconditioning human ventricular cardiomyocytes with brief periods of simulated ischaemia

1994 • 143 citations

Effect of angina pectoris on myocardial protection in patients with reperfused anterior wall myocardial infarction: Retrospective clinical evidence of “preconditioning”

1995 • 141 citations

Infarct size-limiting effect of ischemic preconditioning is blunted by inhibition of 5'-nucleotidase activity and attenuation of adenosine release.

1994 • 137 citations

Relationship between antecedent angina pectoris and short-term prognosis after thrombolytic therapy for acute myocardial infarction

1990 • 134 citations

Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs.

1993 • 134 citations

Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs

1993 • 117 citations

The University Group Diabetes Program

1971 • 114 citations

Adaptation to Exercise in Angina Pectoris

1966 • 111 citations

Ischemic preconditioning

1992 • 108 citations

Effectiveness of glibenclamide on myocardial ischemic ventricular arrhythmias in non-insulin-dependent diabetes mellitus

1991 • 97 citations

Myocardial Infarction in Diabetics

1975 • 96 citations

Long-Term Prognosis After Myocardial Infarction in Men with Diabetes

1985 • 91 citations

Receptor-mediated cardioprotective effects of endogenous adenosine are exerted primarily during reperfusion after coronary occlusion in the rabbit.

1993 • 87 citations

Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury

1993 • 83 citations

Vascular Pharmacology of ATP-Sensitive K<sup>+</sup> Channels: Interactions between Glyburide and K<sup>+</sup> Channel Openers

1993 • 73 citations

Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?

1993 • 71 citations

The University Group Diabetes Program. A statistician looks at the mortality results.

1971 • 63 citations

Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury

1994 • 61 citations

Role of ATP-sensitive K+ channel current in ischemic arrhythmias

1993 • 60 citations

Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds

1990 • 57 citations

The sulphonylurea drug, glimepiride, stimulates release of glycosylphosphatidylinositol-anchored plasma-membrane proteins from 3T3 adipocytes

1993 • 54 citations

Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia

1994 • 53 citations

Myocardial adenosine formation during hypoxia: Effects of ecto-5′-nucleotidase inhibition

1992 • 53 citations

Experience of coronary care in diabetes.

1976 • 52 citations

The University Group Diabetes Program

1971 • 50 citations

Regulation of extracellular adenosine production by ectonucleotidases of adult rat ventricular myocytes

1992 • 48 citations

Molecular mechanisms of action of glyburide on the beta cell

1990 • 46 citations

ATP-sensitive potassium channels in physiology, pathophysiology, and pharmacology

1992 • 40 citations

Effects of glyburide on carbohydrate metabolism and insulin action in the liver

1990 • 35 citations

Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation

1994 • 20 citations

Therapeutic Potential of Potassium Channel Activators in Coronary Heart Disease

1994 • 16 citations

Effects of anesthesia and K+ ATP channel blockade on interstitial adenosine accumulation in ischemic rabbit myocardium

1995 • 9 citations

Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig.

1991 • 6 citations

Induction and Possible Role of Fibrinolysis in Diabetes Mellitus

1991 • 6 citations

Management of Adult-Onset Diabetes

1972 • 4 citations

Summary and closing remarks

1990 • 1 citations