Structure and Function of Mitochondrial Anion Transport Proteins

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Structure of the MscL Homolog from Mycobacterium tuberculosis : A Gated Mechanosensitive Ion Channel

1998 • 972 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Metabolite Transport in Mitochondria

1979 • 618 citations

Transmembrane Protein Structure: Spin Labeling of Bacteriorhodopsin Mutants

1990 • 465 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Structure and function of the uncoupling protein from brown adipose tissue

1999 • 360 citations

The uncoupling protein from brown fat mitochondria is related to the mitochondrial ADP/ATP carrier. Analysis of sequence homologies and of folding of the protein in the membrane.

1985 • 360 citations

Membrane transport proteins: implications of sequence comparisons

1992 • 330 citations

On the Mechanism of Fatty Acid-induced Proton Transport by Mitochondrial Uncoupling Protein

1996 • 322 citations

Internal sequence repeats and the path of polypeptide in mitochondrial ADP/ATP translocase

1982 • 310 citations

Membrane protein oligomeric structure and transport function

1981 • 277 citations

Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.

1987 • 242 citations

Molecular aspects of the adenine nucleotide carrier from mitochondria

1989 • 235 citations

Purification of the carboxy‐atractylate binding protein from mitochondria

1975 • 231 citations

Solute carriers involved in energy transfer of mitochondria form a homologous protein family

1987 • 222 citations

Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria

1993 • 219 citations

The mitochondrial transport protein superfamily

1993 • 213 citations

Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria

1982 • 211 citations

The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.

1994 • 210 citations

Transport Proteins in Bacteria: Common Themes in Their Design

1992 • 200 citations

Highly conserved charge-pair networks in the mitochondrial carrier family

1998 • 190 citations

Sequence of the bovine 2-oxoglutarate/malate carrier protein: structural relationship to other mitochondrial transport proteins

1990 • 165 citations

The mechanism of proton transport mediated by mitochondrial uncoupling proteins

1998 • 164 citations

High Level Expression and Characterization of the Mitochondrial Citrate Transport Protein from the Yeast Saccharomyces cerevisiae

1995 • 159 citations

The mitochondrial tricarboxylate transport protein. cDNA cloning, primary structure, and comparison with other mitochondrial transport proteins

1993 • 159 citations

Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore

1998 • 152 citations

The mitochondrial carnitine carrier protein: cDNA cloning, primary structure and comparison with other mitochondrial transport proteins

1997 • 147 citations

Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria

1989 • 145 citations

Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria.

1982 • 144 citations

Identification of the yeast ACR1 gene product as a succinate‐fumarate transporter essential for growth on ethanol or acetate

1997 • 139 citations

Isolation of the ADP, ATP carrier as the carboxyatractylate · protein complex from mitochondria

1978 • 134 citations

From membrane to molecule to the third amino acid from the left with a membrane transport protein

1997 • 130 citations

The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents

1990 • 126 citations

Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide.

1993 • 124 citations

The Sequence, Bacterial Expression, and Functional Reconstitution of the Rat Mitochondrial Dicarboxylate Transporter Cloned via Distant Homologs in Yeast and Caenorhabditis elegans

1998 • 122 citations

FLX1 Codes for a Carrier Protein Involved in Maintaining a Proper Balance of Flavin Nucleotides in Yeast Mitochondria

1996 • 119 citations

The mitochondrial transporter family

1992 • 117 citations

Identification by bacterial expression and functional reconstitution of the yeast genomic sequence encoding the mitochondrial dicarboxylate carrier protein

1996 • 114 citations

A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein.

1994 • 114 citations

Enrichment and Functional Reconstitution of Glutathione Transport Activity from Rabbit Kidney Mitochondria: Further Evidence for the Role of the Dicarboxylate and 2-Oxoglutarate Carriers in Mitochondrial Glutathione Transport

2000 • 112 citations

Identification of the Yeast Mitochondrial Transporter for Oxaloacetate and Sulfate

1999 • 110 citations

The uncoupling protein from brown adipose tissue mitochondria is a dimer. A hydrodynamic study

1980 • 109 citations

Identification and purification of the tricarboxylate carrier from rat liver mitochondria

1989 • 109 citations

Translocation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline

1995 • 106 citations

Purification and characterization of the reconstitutively active tricarboxylate transporter from rat liver mitochondria.

1990 • 106 citations

Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis

1995 • 101 citations

H⁺ Transport by Uncoupling Protein (UCP-1) Is Dependent on a Histidine Pair, Absent in UCP-2 and UCP-3

1998 • 100 citations

Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a preformed channel as a structural requirement of carrier-mediated transport

1990 • 100 citations

Phylogenetic Classification of the Mitochondrial Carrier Family ofSaccharomyces cerevisiae

1997 • 97 citations

Dialectics in carrier research: The ADP/ATP carrier and the uncoupling protein

1993 • 95 citations

Identification by Site-directed Mutagenesis of Three Arginines in Uncoupling Protein That Are Essential for Nucleotide Binding and Inhibition

1997 • 94 citations

Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significance.

2000 • 92 citations

The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source

1999 • 88 citations

The Phosphate Carrier from Yeast Mitochondria

1998 • 87 citations

Identification of the yeast ARG‐11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis

1997 • 85 citations

The uncoupling protein dimer can form a disulfide cross‐link between the mobile C‐terminal SH groups

1989 • 78 citations

The Reversible Antiport-Uniport Conversion of the Phosphate Carrier from Yeast Mitochondria Depends on the Presence of a Single Cysteine

1997 • 75 citations

A consensus structure for membrane transport

1990 • 74 citations

The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins.

1993 • 70 citations

Reaction mechanism of the reconstituted aspartate/glutamate carrier from bovine heart mitochondria

1988 • 70 citations

Energy-linked anion transport

1989 • 69 citations

Probing the Role of Positive Residues in the ADP/ATP Carrier from Yeast. The Effect of Six Arginine Mutations on Transport and the Four ATP versus ADP Exchange Modes

1996 • 69 citations

Functional principles of solute transport systems: concepts and perspectives

1994 • 69 citations

Kinetic characterization of the reconstituted tricarboxylate carrier from rat liver mitochondria

1990 • 67 citations

The Yeast Mitochondrial Citrate Transport Protein

2000 • 65 citations

Reaction mechanism of the reconstituted oxoglutarate carrier from bovine heart mitochondria

1991 • 64 citations

Transmembrane topology, genes, and biogenesis of the mitochondrial phosphate and oxoglutarate carriers

1993 • 60 citations

Mutagenesis of the Uncoupling Protein of Brown Adipose Tissue. Neutralization of E190 Largely Abolishes pH Control of Nucleotide Binding

1997 • 58 citations

Yeast Mitochondrial Phosphate Transport Protein Expressed in Escherichia coli. Site-Directed Mutations at Threonine-43 and at a Similar Location in the Second Tandem Repeat (Isoleucine-141)

1994 • 57 citations

Reaction mechanism of the reconstituted tricarboxylate carrier from rat liver mitochondria

1993 • 56 citations

Streptozotocin-induced alterations in the levels of functional mitochondrial anion transport proteins

1990 • 56 citations

Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family

1999 • 54 citations

Structure-function relationships of the ADP/ATP carrier

1994 • 52 citations

Fluctuation of the First Loop Facing the Matrix of the Mitochondrial ADP/ATP Carrier Deduced from Intermolecular Cross-Linking of Cys⁵⁶ Residues by Bifunctional Dimaleimides

1998 • 51 citations

Identification of a Novel Gene Encoding the Yeast Mitochondrial Dicarboxylate Transport Protein via Overexpression, Purification, and Characterization of Its Protein Product

1997 • 51 citations

The Yeast Mitochondrial Citrate Transport Protein

2000 • 50 citations

Transmembrane topography of the mitochondrial phosphate carrier explored by peptide-specific antibodies and enzymic digestion

1991 • 49 citations

The N‐ and C‐termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane

1995 • 47 citations

Mitochondrial Phosphate Transport Protein. Replacements of Glutamic, Aspartic, and Histidine Residues Affect Transport and Protein Conformation and Point to a Coupled Proton Transport Path

1996 • 47 citations

High-Yield Bacterial Expression, Purification, and Functional Reconstitution of the Tricarboxylate Transport Protein from Rat Liver Mitochondria

1995 • 46 citations

The mitochondrial carnitine carrier: characterization of SH-groups relevant for its transport function

1992 • 44 citations

Oligomeric state of wild-type and cysteine-less yeast mitochondrial citrate transport proteins.

1999 • 44 citations

Binding of the Fluorescein Derivative Eosin Y to the Mitochondrial ADP/ATP Carrier: Characterization of the Adenine Nucleotide Binding Site

1998 • 42 citations

Transmembrane Topography of the Mitochondrial Oxoglutarate Carrier Assessed by Peptide-Specific Antibodies and Enzymic Cleavage

1994 • 41 citations

The Mitochondrial Oxoglutarate Carrier: Sulfhydryl Reagents Bind to Cysteine-184, and This Interaction Is Enhanced by Substrate Binding

1996 • 36 citations

Deletion of Amino Acids 261−269 in the Brown Fat Uncoupling Protein Converts the Carrier into a Pore

1997 • 36 citations

Structural and functional study of a conserved region in the uncoupling protein UCP1: the three matrix loops are involved in the control of transport

1999 • 36 citations

Structural and functional properties of mitochondrial anion carriers

1990 • 34 citations

In the Uncoupling Protein (UCP-1) His-214 Is Involved in the Regulation of Purine Nucleoside Triphosphate but Not Diphosphate Binding

1998 • 34 citations

A transport system for coenzyme A in isolated rat heart mitochondria.

1987 • 33 citations

Thiamine pyrophosphate uptake into isolated rat liver mitochondria

1990 • 33 citations

Antibodies selected from whole antiserum by fusion proteins as tools for the study of the topology of mitochondrial membrane proteins. Evidence that the N-terminal extremity of the sixth alpha-helix of the uncoupling protein is facing the matrix.

1992 • 32 citations

Structure-function of the ADP/ATP carrier

1992 • 32 citations

The effect of insulin supplementation on diabetes-induced alterations in the extractable levels of functional mitochondrial anion transport proteins

1991 • 31 citations

Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology.

1990 • 30 citations

Transport of N‐Acetylglutamate in Rat‐Liver Mitochondria

1982 • 29 citations

Cloning, Genomic Organization, and Chromosomal Localization of Human Citrate Transport Protein to the DiGeorge/Velocardiofacial Syndrome Minimal Critical Region

1996 • 27 citations

The human mitochondrial citrate transporter gene (SLC20A3) maps to chromosome band 22q11 within a region implicated in DiGeorge syndrome, velo-cardio-facial syndrome and schizophrenia

1996 • 26 citations

Two-Stage Nucleotide Binding Mechanism and Its Implications to H⁺Transport Inhibition of the Uncoupling Protein from Brown Adipose Tissue Mitochondria

1996 • 25 citations

Replacements of Basic and Hydroxyl Amino Acids Identify Structurally and Functionally Sensitive Regions of the Mitochondrial Phosphate Transport Protein

1999 • 24 citations

The Yeast Mitochondrial Citrate Transport Protein: Determination of Secondary Structure and Solvent Accessibility of Transmembrane Domain IV Using Site-Directed Spin Labeling

2000 • 23 citations

Kinetic study of the aspartate/glutamate carrier in intact rat heart mitochondria and comparison with a reconstituted system

1991 • 22 citations

Interaction of fluorescein with the dicarboxylate carrier in rat kidney cortex mitochondria.

1996 • 15 citations

Bacterial overexpression of putative yeast mitochondrial transport proteins.

1997 • 10 citations

Channel Properties of Mitochondrial Carriers

1994 • 8 citations

Kinetic Mechanisms of the Adenylic and the Oxoglutaric Carriers: a Comparison

1989 • 5 citations

Structural and functional properties of two mitochondrial transport proteins: the phosphate carrier and the oxoglutarate carrier

1992 • 5 citations

Further insight into the structural properties of the mitochondrial oxoglutarate carrier

1995 • 3 citations