Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significance.

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Over-production of Proteins inEscherichia coli: Mutant Hosts that Allow Synthesis of some Membrane Proteins and Globular Proteins at High Levels

1996 • 1,892 citations

Reconstitution and Purification of the D-Glucose Transport Protein from Human Erythrocytes

1977 • 652 citations

Mitochondrial carrier proteins

1994 • 337 citations

[25] Mitochondrial metabolite carrier proteins: Purification, reconstitution, and transport studies

1995 • 234 citations

The metabolic significance of anion transport in mitochondria

1974 • 225 citations

Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria

1993 • 219 citations

Compartmental and regulatory mechanisms in the arginine pathways of Neurospora crassa and Saccharomyces cerevisiae

1986 • 219 citations

A third ADP/ATP translocator gene in yeast.

1990 • 205 citations

Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane.

1986 • 202 citations

Highly conserved charge-pair networks in the mitochondrial carrier family

1998 • 190 citations

Kinetic Study of the Dicarboxylate Carrier in Rat Liver Mitochondria

1971 • 185 citations

Separate genes encode functionally equivalent ADP/ATP carrier proteins in Saccharomyces cerevisiae. Isolation and analysis of AAC2.

1988 • 173 citations

Quantitative Correlation between the Distribution of Anions and the pH Difference across the Mitochondrial Membrane

1970 • 161 citations

High Level Expression and Characterization of the Mitochondrial Citrate Transport Protein from the Yeast Saccharomyces cerevisiae

1995 • 159 citations

Effect of sulphydryl‐blocking reagents on mitochondrial anion‐exchange reactions involving phosphate

1970 • 141 citations

The Regulation of Arginine Biosynthesis in Saccharomyces cerevisiae. The Specificity of argR- Mutations and the General Control of Amino-Acid Biosynthesis

1975 • 141 citations

Identification of the yeast ACR1 gene product as a succinate‐fumarate transporter essential for growth on ethanol or acetate

1997 • 139 citations

Expression in Escherichia coli, Functional Characterization, and Tissue Distribution of Isoforms A and B of the Phosphate Carrier from Bovine Mitochondria

1998 • 136 citations

The Sequence, Bacterial Expression, and Functional Reconstitution of the Rat Mitochondrial Dicarboxylate Transporter Cloned via Distant Homologs in Yeast and Caenorhabditis elegans

1998 • 122 citations

Identification by bacterial expression and functional reconstitution of the yeast genomic sequence encoding the mitochondrial dicarboxylate carrier protein

1996 • 114 citations

Factors influencing the activity of ornithine aminotransferase in isolated rat liver mitochondria

1977 • 113 citations

Relationship between Intracellular Distribution of Phosphoenolpyruvate Carboxykinase, Regulation of Gluconeogenesis, and Energy Cost of Glucose Formation

1973 • 110 citations

Kinetic characterization of the reconstituted carnitine carrier from rat liver mitochondria

1991 • 107 citations

Phylogenetic Classification of the Mitochondrial Carrier Family ofSaccharomyces cerevisiae

1997 • 97 citations

The ICL1 gene from Saccharomyces cerevisiae

1992 • 96 citations

Anion translocators in rat‐heart mitochondria

1971 • 95 citations

Control of Succinate Oxidation by Succinate‐Uptake by Rat‐Liver Mitochondria

1968 • 94 citations

The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source

1999 • 88 citations

Identification of the yeast ARG‐11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis

1997 • 85 citations

Rate-Limiting Steps of Gluconeogenesis in Liver Cells as Determined with the Aid of Fluoro-Dicarboxylic Acids

1972 • 77 citations

Characterization of the unidirectional transport of carnitine catalyzed by the reconstituted carnitine carrier from rat liver mitochondria

1991 • 77 citations

Bacterial Overexpression, Purification, and Reconstitution of the Carnitine/Acylcarnitine Carrier from Rat Liver Mitochondria

1998 • 76 citations

Inhibition of Gluconeogenesis by Butylmalonate in Perfused Rat Liver

1970 • 69 citations

The transport of sulphate and sulphite in rat liver mitochondria

1974 • 64 citations

Identification and purification of the ornithine/citrulline carrier from rat liver mitochondira

1992 • 60 citations

Evidence for the existence of an ornithine/citrulline antiporter in rat liver mitochondria

1980 • 58 citations

Yeast Mitochondrial Phosphate Transport Protein Expressed in Escherichia coli. Site-Directed Mutations at Threonine-43 and at a Similar Location in the Second Tandem Repeat (Isoleucine-141)

1994 • 57 citations

The ARG11 Gene of Saccharomyces cerevisiae Encodes a Mitochondrial Integral Membrane Protein Required for Arginine Biosynthesis

1996 • 56 citations

Sequences Required for Delivery and Localization of the ADP/ATP Translocator to the Mitochondrial Inner Membrane

1986 • 56 citations

Functional properties of the reconstituted phosphate carrier from bovine heart mitochondria: Evidence for asymmetric orientation and characterization of three different transport modes

1993 • 55 citations

Localization and targeting of isocitrate lyases in Saccharomyces cerevisiae

1996 • 55 citations

Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family

1999 • 54 citations

Identification of a Novel Gene Encoding the Yeast Mitochondrial Dicarboxylate Transport Protein via Overexpression, Purification, and Characterization of Its Protein Product

1997 • 51 citations

The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria: electrical nature and coupling of the exchange reaction with H+ translocation

1997 • 51 citations

Mechanism of inhibition of the dicarboxylate carrier of mitochondria by thiol reagents

1974 • 50 citations

The transport of thiosulphate in rat liver mitochondria

1974 • 48 citations

High-Yield Bacterial Expression, Purification, and Functional Reconstitution of the Tricarboxylate Transport Protein from Rat Liver Mitochondria

1995 • 46 citations

Kinetics of the reconstituted dicarboxylate carrier from rat liver mitochondria

1989 • 41 citations

The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p

1998 • 39 citations

ACR1, a gene encoding a protein related to mitochondrial carriers, is essential for acetyl-CoA synthetase activity in Saccharomyces cerevisiae

1994 • 39 citations

Kinetic characterization of the reconstituted ornithine carrier from rat liver mitochondria

1994 • 38 citations

Kinetic characterization of the reconstituted dicarboxylate carrier from mitochondria: a four-binding-site sequential transport system

1993 • 35 citations

The uptake of ornithine and lysine by rat liver mitochondria

1983 • 33 citations

Elucidation by ionophores of the a ΔpH control of anion distribution across the mitochondrial membrane

1970 • 32 citations

Biogenesis of mitochondria. The effects of physiological and genetic manipulation of Saccharomyces cerevisiae on the mitochondrial transport systems for tricarboxylate-cycle anions

1973 • 32 citations

Transport of arginine and ornithine into isolated mitochondria of Saccharomyces cerevisiae

1998 • 26 citations

The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria catalyses a second transport mode: ornithine+/H+ exchange

1999 • 22 citations

Malate exchange between the cytosol and mitochondria

1973 • 17 citations

Effect on gluconeogenesis of mutants blocking two mitochondrial transport systems in the yeast Saccharomyces cerevisiae

1986 • 16 citations

Bacterial overexpression of putative yeast mitochondrial transport proteins.

1997 • 10 citations

Multiple regulatory elements control the expression of the yeast ACR1 gene

1999 • 10 citations

Effects of mutants and inhibitors on mitochondrial transport systems in vivo in yeast

1984 • 5 citations

Assignment<footref rid="foot01"><sup>1</sup></footref> of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3

1998 • 3 citations