Multiple signaling pathways leading to the activation of interferon regulatory factor 3

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Antiviral Actions of Interferons

2001 • 2,683 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

2001 • 1,231 citations

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

2001 • 1,078 citations

Viruses and Interferons

2001 • 985 citations

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

2000 • 927 citations

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 • 901 citations

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

1998 • 812 citations

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

2002 • 802 citations

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

1998 • 723 citations

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

1998 • 602 citations

Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

2000 • 580 citations

Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes

2002 • 510 citations

Activation and function of natural killer cell responses during viral infections

1997 • 430 citations

Murine retroviruses activate B cells via interaction with toll-like receptor 4

2002 • 388 citations

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

1999 • 384 citations

NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase

2000 • 347 citations

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

1998 • 334 citations

Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains

1999 • 319 citations

Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

1998 • 278 citations

Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7

2000 • 274 citations

Roles of Toll‐like receptors in innate immune responses

2001 • 262 citations

Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways

2001 • 261 citations

IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein

2001 • 223 citations

PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex

2000 • 216 citations

A new pathway of translational regulation mediated by eukaryotic initiation factor 3

2000 • 213 citations

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

2000 • 206 citations

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH₂-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways

2000 • 203 citations

Identification of Distinct Signaling Pathways Leading to the Phosphorylation of Interferon Regulatory Factor 3

2001 • 193 citations

RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA

2000 • 180 citations

Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation

2002 • 167 citations

The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis

2000 • 159 citations

Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding Complex

1998 • 158 citations

Structure and function of Toll-like receptor proteins

2000 • 137 citations

p38-dependent Activation of Interferon Regulatory Factor 3 by Lipopolysaccharide

1999 • 125 citations

Lipopolysaccharide Activates the Expression of ISG15-specific Protease UBP43 via Interferon Regulatory Factor 3

2002 • 121 citations

Interferon regulatory factor-3 is an in vivo target of DNA-PK

2002 • 120 citations

Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs

2001 • 99 citations

MultiplecisRegulatory Elements Control RANTES Promoter Activity in Alveolar Epithelial Cells Infected with Respiratory Syncytial Virus

2001 • 99 citations

Activation of Interferon Regulatory Factor 3 in Response to DNA-damaging Agents

1999 • 95 citations

Review: Overlapping and Distinct Mechanisms Regulating IRF-3 and IRF-7 Function

2002 • 93 citations

Bacterial Induction of Beta Interferon in Mice Is a Function of the Lipopolysaccharide Component

2000 • 83 citations

Apoptosis is promoted by the dsRNA‐activated factor (DRAF1) during viral infection independent of the action of interferon or p53

2001 • 66 citations

PACT, a Double-Stranded RNA Binding Protein Acts as a Positive Regulator for Type I Interferon Gene Induced by Newcastle Disease Virus

2001 • 45 citations

Signaling Pathways to the Assembly of an Interferon-β Enhanceosome

2000 • 45 citations

Lipopolysaccharide Inhibits Virus-mediated Induction of Interferon Genes by Disruption of Nuclear Transport of Interferon Regulatory Factors 3 and 7

1999 • 23 citations