Halofuginone inhibition of COL1A2 promoter activity via a c‐Jun–dependent mechanism

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.

1986 • 1,129 citations

Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

2001 • 896 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity

2001 • 680 citations

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling

2001 • 419 citations

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

2000 • 412 citations

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1999 • 388 citations

Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo.

1998 • 379 citations

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β

1996 • 312 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

2000 • 303 citations

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma.

1999 • 297 citations

c-Jun–dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid

2000 • 292 citations

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.

1996 • 290 citations

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

1998 • 257 citations

Anti-TGF-β Treatment Prevents Skin and Lung Fibrosis in Murine Sclerodermatous Graft-Versus-Host Disease: A Model for Human Scleroderma

1999 • 248 citations

Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis.

2000 • 227 citations

Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor β1 Stimulation of α2(I)-Collagen (COL1A2) Transcription

2000 • 213 citations

Mechanism of action of a dominant-negative mutant of c-Jun.

1994 • 207 citations

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

2001 • 205 citations

Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins.

1992 • 198 citations

Interaction of Smad3 with a proximal smad-binding element of the human ?2(I) procollagen gene promoter required for transcriptional activation by TGF-?

2000 • 180 citations

Sp1 Is Required for the Early Response of α2(I) Collagen to Transforming Growth Factor-β1

1997 • 175 citations

Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth-Factor-β-Mediated Smad3 Activation in Fibroblasts

2002 • 165 citations

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

1997 • 140 citations

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats

2001 • 140 citations

Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

1997 • 139 citations

Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts

2001 • 130 citations

Halofuginone: An inhibitor of collagen type I synthesis

1993 • 111 citations

Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis.

1996 • 106 citations

Halofuginone: a potent inhibitor of critical steps in angiogenesis progression

2000 • 102 citations

Infusion of iloprost, a prostacyclin analogue, for treatment of Raynaud's phenomenon in systemic sclerosis.

1988 • 100 citations

Expression of Interleukin-4 in Scleroderma Skin Specimens and Scleroderma Fibroblast Cultures

1996 • 98 citations

Analysis of p53 Gene Mutations in Keloids Using Polymerase Chain Reaction–Based Single-Strand Conformational Polymorphism and DNA Sequencing

1998 • 97 citations

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation

2001 • 95 citations

Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: Effect of halofuginone

1996 • 92 citations

Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone.

1999 • 87 citations

Antagonistic Effects of Interferon-γ and Interleukin-4 on Fibroblast Cultures.

1997 • 86 citations

c-Jun Inhibits Transforming Growth Factor β-mediated Transcription by Repressing Smad3 Transcriptional Activity

2000 • 86 citations

Clinical manifestations of systemic sclerosis

1998 • 82 citations

LUNG INTERLEUKIN-4 GENE EXPRESSION IN A MURINE MODEL OF BLEOMYCIN-INDUCED PULMONARY FIBROSIS

2001 • 79 citations

Increased Skin Tearing in Broilers and Reduced Collagen Synthesis in Skin In Vivo and In Vitro in Response to the Coccidiostat Halofuginone

1991 • 76 citations

Estradiol suppresses type I collagen synthesis in mesangial cells via activation of activator protein-1

1999 • 74 citations

Relaxin Alone and in Conjunction with Interferon-γ Decreases Collagen Synthesis by Cultured Human Scleroderma Fibroblasts

1992 • 68 citations

Relaxin favors the development of activated human T cells into Th1-like effectors

1999 • 61 citations

Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: Association with increased expression of the type I collagen gene

2000 • 54 citations

Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone

2001 • 51 citations

Oncostatin M: a cytokine upregulated in human cirrhosis, increases collagen production by human hepatic stellate cells

2000 • 51 citations

Halofuginone, an inhibitor of collagen type I synthesis, prevents postoperative adhesion formation in the rat uterine horn model

1999 • 50 citations

Pentoxifylline inhibits human peritoneal mesothelial cell growth and collagen synthesis: Effects on TGF-β

2000 • 49 citations

Regulatory mechanisms for transforming growth factorβ as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of Smads in its growth

2000 • 48 citations

Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor‐β₁

1997 • 46 citations

Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis.

1998 • 45 citations

Increased α1(I) Procollagen Gene Expression in Tight Skin (TSK) Mice Myocardial Fibroblasts Is Due to a Reduced Interaction of a Negative Regulatory Sequence with AP-1 Transcription Factor

1995 • 39 citations

An Activator Protein-1 (AP-1) Response Element on Pro α1(l) Collagen Gene is Necessary for Thyroid Hormone-Induced Inhibition of Promoter Activity in Cardiac Fibroblasts

1998 • 34 citations

Interaction of Ap1, Ap2, and Sp1 with the Regulatory Regions of the Human Pro-α1(I) Collagen Gene

2000 • 23 citations

Transcriptional repression of the α1(I) collagen gene by ras is mediated in part by an intronic AP1 site

1995 • 22 citations

Pregnant Mouse Corpora Lutea: Immunocytochemical Localization of Relaxin and Ultrastructure

1984 • 22 citations

Immunocytochemical studies of relaxin in ovaries of pregnant and cycling mice.

1985 • 11 citations

Fibrillin-1 Protein in Tight Skin Mice and Scleroderma

2000 • 6 citations