Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Methods of Enzymatic Analysis

1975 • 20,446 citations

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

GLUTATHIONE

1983 • 5,487 citations

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

1967 • 2,311 citations

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

1990 • 828 citations

Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients

1991 • 543 citations

Increased tumor necrosis factor production by monocytes in alcoholic hepatitis

1989 • 542 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Alcohol and the liver: 1994 update

1994 • 511 citations

AMPLIFICATION OF RNA

1990 • 486 citations

Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis

1990 • 470 citations

Alcohol and the Liver

1992 • 421 citations

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins.

1992 • 373 citations

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

1987 • 358 citations

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.

1995 • 339 citations

Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines

1993 • 319 citations

Plasma Tumor Necrosis Factor α Predicts Decreased Long‐Term Survival in Severe Alcoholic Hepatitis

1990 • 305 citations

Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat

1988 • 298 citations

Cytokines and Alcoholic Liver Disease

1993 • 292 citations

Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.

1987 • 235 citations

Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease

1993 • 232 citations

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

1992 • 228 citations

Genes coding for RNA polymerase β subunit in bacteria

1988 • 225 citations

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes.

1994 • 221 citations

Feeding S -adenosyl-l-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

1995 • 205 citations

Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins

1997 • 203 citations

Excessivein vitro bacterial lipopolysaccharide-induced production of monokines in cirrhosis

1990 • 184 citations

Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase

1997 • 145 citations

Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis.

1991 • 144 citations

Oxidative stress and liver disease.

1996 • 143 citations

Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells.

1991 • 105 citations

Induction of drug metabolizing enzymes in human liver cell line Hep G2

1985 • 96 citations

Direct Blood-Injection Method for Gas Chromatographic Determination of Alcohols and Other Volatile Compounds

1971 • 93 citations

Review

1996 • 82 citations

Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response.

1994 • 80 citations

Lactate dehydrogenase isoenzymes

1988 • 78 citations

Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes

1990 • 77 citations

In Vitro Assessment of the Ethanol-Induced Hepatotoxicity on HepG2 Cell Line

1993 • 74 citations

Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis

1994 • 74 citations

Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line

1995 • 73 citations

A quantitative assay for fragmented DNA in apoptotic cells

1992 • 64 citations

A simple microplate assay for the determination of cellular protein

1985 • 49 citations

Plasma Membrane and Mitochondrial Transport of Hepatic Reduced Glutathione

1996 • 45 citations

Induction of an acute phase response in rats stimulates the expression of alpha 1(I) procollagen messenger ribonucleic acid in their livers. Possible role of interleukin-6.

1995 • 44 citations

Enhancement of in vivo cell-mediated immune responses by three distinct cytokines.

1990 • 41 citations

Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes

1987 • 40 citations

Clinical and Analytical Concepts in Enzymology

1984 • 28 citations

Modulation of liver-specific cellular response to ethanol in vitro in hep G2 cells

1998 • 23 citations

Human hepatoma cells synthesize and secrete lysozyme: Modulation by cytokines

1994 • 17 citations

Enzyme diversion applied to the kinetic estimation of glucose-6-phosphatase activity

1969 • 12 citations

Homogeneous trinder-coupled assay for the determination of glucose-6-phosphatase activity in tissue extracts

1992 • 8 citations

Lactate Dehydrogenase, Isoenzymes

1974 • 4 citations

Deleted Work

1955 • 0 citations