Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells

Methoden der enzymatischen Analyse

1962 • 3,983 citations

BMPD statistical software manual

1988 • 2,605 citations

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

1997 • 1,015 citations

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

1997 • 778 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Importance of Glucose-6-phosphate Dehydrogenase Activity for Cell Growth

1998 • 511 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

In vivo differentiation of rat liver oval cells into hepatocytes.

1989 • 318 citations

Gamma-glutamyl transpeptidase – its role in hepatocarcinogenesis

1985 • 313 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Glycolysis, glutaminolysis and cell proliferation

1982 • 305 citations

Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts.

1989 • 266 citations

Modulation of type M ₂ pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

1999 • 247 citations

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.

1997 • 244 citations

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.

1993 • 196 citations

Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells

1990 • 195 citations

Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism

1985 • 188 citations

Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.

1996 • 176 citations

COMPARATIVE BIOCHEMISTRY OF HEPATOMAS. III. CARBOHYDRATE ENZYMES IN LIVER TUMORS OF DIFFERENT GROWTH RATES.

1963 • 171 citations

Amino acid, glucose, and lactic acid utilization in vivo by rat tumors.

1982 • 152 citations

The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.

1997 • 151 citations

Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review.

1977 • 142 citations

Mitochondrial malic enzymes. Mitochondrial NAD(P)+-dependent malic enzyme activity and malate-dependent pyruvate formation are progression-linked in Morris hepatomas.

1980 • 114 citations

Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity

1991 • 111 citations

Pre-cancerous steps in carcinogenesis Their physicological adaptive nature

1984 • 110 citations

Effect of Extracellular AMP on Cell Proliferation and Metabolism of Breast Cancer Cell Lines with High and Low Glycolytic Rates

1997 • 103 citations

Isozyme profiles of oval cells, parenchymal cells, and biliary cells isolated by centrifugal elutriation from normal and preneoplastic livers.

1984 • 94 citations

The Oxidative Metabolism of Glutamine

1996 • 92 citations

Isolation, Biochemical Characterization, Long-Term Culture, and Phenotype Modulation of Oval Cells from Carcinogen-Fed Rats

1993 • 81 citations

Metabolism of hepatomas of different growth rates in situ and during ischemia.

1971 • 80 citations

End products of glucose and glutamine metabolism by cultured cell lines

1988 • 79 citations

Metabolic Alterations Associated with Proliferation of Mitogen-Activated Lymphocytes and of Lymphoblastoid Cell Lines: Evaluation of Glucose and Glutamine Metabolism

1986 • 79 citations

Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL- ethionine-supplemented diet

1998 • 77 citations

Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies

1996 • 73 citations

Compartmentation of Lactate and Glucose Metabolism in C6 Glioma Cells

1998 • 66 citations

Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties

1980 • 66 citations

Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.

1994 • 64 citations

Differentiation of oval cells into duct-like cells in preneoplastic liver of rats placed on a choline-deficient diet supplemented with ethionine

1994 • 62 citations

Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.

1980 • 61 citations

Expression of pyruvate kinase M 2 in preneoplastic hepatic foci of N -nitrosomorpholine-treated rats

1999 • 60 citations

Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts

1991 • 57 citations

Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors.

1998 • 57 citations

Dual phenotypic expression of hepatocytes and bile ductular markers in developing and preneoplastic rat liver

1996 • 55 citations

Bioenergetics of tumor cells: Glutamine metabolism in tumor cell mitochondria

1987 • 54 citations

Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet

1991 • 47 citations

In vitro effect of extracellular AMP on MCF‐7 breast cancer cells: Inhibition of glycolysis and cell proliferation

1992 • 44 citations

Plasma glutamate levels, lymphocyte reactivity and death rate in patients with bronchial carcinoma

1989 • 41 citations

Studies on associations of glycolytic and glutaminolytic enzymes in MCF-7 cells: Role of P36

1996 • 39 citations

Examination of enzyme-altered foci with gamma-glutamyl transpeptidase, aldehyde dehydrogenase, glucose-6-phosphate dehydrogenase, and other markers in methacrylate-embedded liver.

1987 • 39 citations

Metabolic characteristics of different malignant cancer cell lines.

1998 • 37 citations

Inhibition of glycolysis by amino acids in ascites tumor cells. Specificity and mechanism.

1993 • 35 citations

Effect of Oncogene Transformation of Rat Embryo Cells on Cellular Oxygen Consumption and Glycolysis

1997 • 35 citations

13C and 31P NMR Investigation of Effect of 6-Aminonicotinamide on Metabolism of RIF-1 Tumor Cells in Vitro

1996 • 34 citations

Negative correlation of L-glutamine concentration with proliferation rate in rat hepatomas

1984 • 29 citations

Isozyme patterns of pyruvate kinase in various primary liver tumors induced during the process of hepatocarcinogenesis.

1974 • 29 citations

Pyruvate kinase isoenzymes in altered foci and carcinoma of rat liver

1986 • 25 citations

Immunohistochemical demonstration of decreased L-pyruvate kinase in enzyme altered rat liver lesions produced by different carcinogens

1987 • 23 citations

Double role of pyruvate kinase type M2 in the regulation of phosphometabolite pools

1998 • 21 citations

Expression of L- and M₂-pyruvate kinases in proliferating oval cells and cholangiocellular lesions developing in the livers of rats fed a methyl-deficient diet

1994 • 18 citations

Effect of S-adenosyl-L-methionine on the development of preneoplastic foci and the activity of some carbohydrate metabolizing enzymes in the liver, during experimental hepatocarcinogenesis.

1993 • 17 citations

Hormone-sensitive carbohydrate metabolism in rat hepatocyte-hepatoma hybrid cells.

1992 • 16 citations

Correlation between the rates of aerobic glycolysis and glucose transport, unrelated to neoplastic transformation, in a series of BALB 3T3-derived cell lines.

1982 • 15 citations

Density-dependent changes in hexose transport, glycolytic enzyme levels, and glycolytic rates, in uninfected and murine sarcoma virus-transformed rat kidney cells

1977 • 12 citations

A Study of the Activities of Carbohydrate-Metabolizing Enzymes and the Levels of Carbohydrate Metabolites and Amino Acids in Normal Liver and in Hepatocellular Carcinoma

1988 • 8 citations

Comparative Study on the Effect of Different Treatment Schedules on Some Carbohydrate Metabolizing Enzyme Activities in Rats During Hepatocarcinogenesis

1988 • 4 citations