Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies

A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3.

1962 • 773 citations

Replacement of Diseased Mouse Liver by Hepatic Cell Transplantation

1994 • 573 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

Combined hepatocellular-cholangiocarcinoma. A histologic and immunohistochemical study

1985 • 429 citations

Cell lineages and oval cell progenitors in rat liver development.

1991 • 391 citations

Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.

1991 • 376 citations

In vivo differentiation of rat liver oval cells into hepatocytes.

1989 • 318 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

1989 • 294 citations

THE KINETICS OF CELLULAR PROLIFERATION IN REGENERATING LIVER

1968 • 288 citations

The streaming liver

1985 • 271 citations

The liver as a stem cell and lineage system

1992 • 237 citations

"Lifespan" of Liver Cells

1961 • 228 citations

Complete reconstitution of mouse liver with xenogeneic hepatocytes.

1995 • 217 citations

Biliary epithelial and hepatocytic cell lineage relationships in embryonic rat liver as determined by the differential expression of cytokeratins, alpha-fetoprotein, albumin, and cell surface-exposed components.

1988 • 213 citations

Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment.

1993 • 185 citations

Autoradiographic Investigation of Incorporation of H ³ -Thymidine into Cells of the Rat and Mouse

1960 • 148 citations

Cell lineage study in the liver using retroviral mediated gene transfer. Evidence against the streaming of hepatocytes in normal liver.

1994 • 145 citations

Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. A light- and electron-microscopic analysis.

1987 • 143 citations

Regeneration of the Liver

1959 • 142 citations

Promotion of growth and differentiation of rat ductular oval cells in primary culture.

1988 • 142 citations

Isolation, Culture, and Transplantation of Intrahepatic Biliary Epithelial Cells and Oval Cells

1990 • 141 citations

The streaming liver II. Hepatocyte life history

1988 • 121 citations

Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats.

1987 • 116 citations

Liver-directed gene therapy: quantitative evaluationof promoter elements by using in vivo retroviral transduction.

1994 • 111 citations

Cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms.

1990 • 98 citations

Significance of the so-called oval cell proliferation during azo-dye hepatocarcinogenesis.

1967 • 98 citations

The stem cells of the liver ? a selective review

1992 • 85 citations

Cancer, retrodifferentiation, and the myth of Faust.

1976 • 84 citations

Hepatic stem cells.

1993 • 82 citations

Hepatic Progenitor Populations in Embryonic, Neonatal, and Adult Liver

1993 • 78 citations

Isolation and partial characterizations of oval and hyperplastic bile ductular cell-enriched populations from the livers of carcinogen and noncarcinogen-treated rats.

1984 • 76 citations

Models for Hepatic Progenitor Cell Activation

1993 • 68 citations

Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants.

1991 • 66 citations

Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.

1994 • 64 citations

Hepatic gene therapy: Present and future

1993 • 60 citations

Tumorigenicity of simian virus 40-hepatocyte cell lines: effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes.

1988 • 60 citations

Migration of hepatocytes along hepatic plates and stem cell-fed hepatocyte lineages.

1994 • 49 citations

Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus‐associated oncogenes

1988 • 45 citations

Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice.

1991 • 45 citations

Expression of hepatocyte and oval cell antigens in hepatocellular carcinomas produced by oncogene-transfected liver epithelial cells.

1990 • 42 citations

Cell kinetics in the liver of rats under normal and abnormal dietary conditions

1977 • 29 citations

Reutilization of 5-125I-Iodo-2'-Deoxyuridine and 3H-Thymidine in Regenerating Liver of Mice

1971 • 26 citations

ras transformation of simian virus 40-immortalized rat hepatocytes: an in vitro model of hepatocarcinogenesis.

1992 • 9 citations