Double role of pyruvate kinase type M2 in the regulation of phosphometabolite pools

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

1979 • 1,228 citations

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant

1971 • 411 citations

Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins

1985 • 331 citations

Glycolysis, glutaminolysis and cell proliferation

1982 • 305 citations

Permeation of Glucose by Simple and Facilitated Diffusion by Novikoff Rat Hepatoma Cells in Suspension Culture and Its Relationship to Glucose Metabolism

1972 • 215 citations

Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.

1992 • 209 citations

In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate.

1991 • 166 citations

Use of an antiserum against phosphotyrosine for the identification of phosphorylated components in human fibroblasts stimulated by platelet-derived growth factor.

1984 • 163 citations

Glycolysis as Primary Energy Source in Tumor Cell Chemotaxis

1990 • 129 citations

The continuous growth of vertebrate cells in the absence of sugar.

1981 • 114 citations

Effect of Extracellular AMP on Cell Proliferation and Metabolism of Breast Cancer Cell Lines with High and Low Glycolytic Rates

1997 • 103 citations

Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase.

1989 • 97 citations

Alterations in Glucose Metabolism in Chick-Embryo Cells Transformed by Rous Sarcoma Virus: Intracellular Levels of Glycolytic Intermediates

1974 • 95 citations

Metabolism of hepatomas of different growth rates in situ and during ischemia.

1971 • 80 citations

Pyruvate kinase type M₂ is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus

1988 • 79 citations

Epidermal growth factor stimulates tyrosine phosphorylation of specific proteins in permeabilized human fibroblasts.

1985 • 76 citations

Biochemical and Molecular Aspects of Selected Cancers

1991 • 74 citations

Five enzymes of the glycolytic pathway serve as substrates for purified epidermal-growth-factor-receptor kinase

1986 • 71 citations

Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma

1988 • 61 citations

Toxicity and effects of epidermal growth factor on glucose metabolism of MDA-468 human breast cancer cells.

1990 • 57 citations

Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses

1986 • 53 citations

End products of glucose and glutamine metabolism by L929 cells.

1987 • 52 citations

Dynamics of Metabolism of Normal and Virus-Transformed Chick Cells in Culture

1973 • 45 citations

In vitro effect of extracellular AMP on MCF‐7 breast cancer cells: Inhibition of glycolysis and cell proliferation

1992 • 44 citations

The role of phosphofructokinase in the Pasteur effect

1978 • 38 citations

Purification and properties of mouse pyruvate kinases K and M and of a modified K subunit

1981 • 34 citations

Carbohydrate Metabolism and Neoplasia: New Perspectives for Diagnosis and Therapy

1994 • 33 citations

Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus.

1978 • 33 citations

Influence of transformation by Rous sarcoma virus on the amount, phosphorylation and enzyme kinetic properties of enolase.

1983 • 31 citations

Phosphorylation of pyruvate kinase type K is restricted to the dimeric form

1992 • 21 citations

On the mechanism of the glucose-induced ATP catabolism in ascites tumour cells and its reversal by pyruvate

1980 • 20 citations

Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.

1990 • 18 citations

Changes in the synthesis and phosphorylation of cellular proteins in chick fibroblasts transformed by two avian sarcoma viruses.

1984 • 15 citations

Phosphorylation of Pyruvate Kinase and Glycolytic Metabolism in Three Human Glioma Cell Lines

1991 • 14 citations

Transformation‐associated increase of phosphoribosyl pyrophosphate concentration in chick embryo fibroblasts

1979 • 5 citations