Spacial Compartmentalization of Ca2+ Signaling Complexes in Pancreatic Acini

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

G proteins

1992 • 871 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

New roles for G-protein (βγ-dimers in transmembrane signalling

1993 • 633 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Caveolae: where incoming and outgoing messengers meet.

1993 • 616 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate

1993 • 488 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

1995 • 436 citations

Stimulus‐secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells.

1992 • 433 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Different β-subunits determine G-protein interaction with transmembrane receptors

1992 • 390 citations

Subcellular distribution of Ca2+ release channels underlying Ca2+ waves and oscillations in exocrine pancreas

1993 • 357 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1.

1992 • 340 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Hormone-evoked calcium release from intracellular stores is a quantal process

1989 • 312 citations

The Pancreas: Biology, Pathobiology, and Disease

1994 • 305 citations

Plasmalemmal caveolae and GPI-anchored membrane proteins

1993 • 186 citations

Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx.

1994 • 179 citations

Mechanism of Ca2+ wave propagation in pancreatic acinar cells.

1992 • 159 citations

Role of free cytosolic calcium in secretagogue-stimulated amylase release from dispersed acini from guinea pig pancreas.

1985 • 150 citations

The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism.

1987 • 142 citations

Gap junction communication modulates [Ca2+]i oscillations and enzyme secretion in pancreatic acini.

1993 • 113 citations

The route of Ca2+ entry during reloading of the intracellular Ca2+ pool in pancreatic acini.

1990 • 104 citations

Acetylcholine and cholecystokinin induce different patterns of oscillating calcium signals in pancreatic acinar cells

1991 • 103 citations

Synchronized oscillation of Ca2+ entry and Ca2+ release in agonist-stimulated AR42J cells

1991 • 74 citations

Characterization, localization and axial distribution of Ca2+ signalling receptors in the rat submandibular salivary gland ducts.

1996 • 56 citations

Gβγ Transduces [Ca2+] Oscillations and Gαq a Sustained Response during Stimulation of Pancreatic Acinar Cells with [Ca2+] -mobilizing Agonists

1996 • 48 citations

Compartmentalization of Ca2+ signaling and Ca2+ pools in pancreatic acini. Implications for the quantal behavior of Ca2+ release.

1994 • 37 citations

Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells.

1988 • 35 citations

Antagonists inactivate the inositol 1,4,5-trisphosphate (Ins-1,4,5-P3)-dependent Ca2+ channel independent of Ins-1,4,5-P3 metabolism.

1994 • 11 citations