Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I

Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

1990 • 5,586 citations

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

2001 • 3,292 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Aggresomes: A Cellular Response to Misfolded Proteins

1998 • 2,116 citations

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

2001 • 1,714 citations

Left Ventricular Hypertrophy

2000 • 1,197 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Prognostic Significance of Serial Changes in Left Ventricular Mass in Essential Hypertension

1998 • 652 citations

CHIP Is a U-box-dependent E3 Ubiquitin Ligase

2001 • 574 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts

1996 • 429 citations

Molecular mechanisms modulating muscle mass

2003 • 428 citations

Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium

1997 • 392 citations

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

2001 • 383 citations

Troponin I Degradation and Covalent Complex Formation Accompanies Myocardial Ischemia/Reperfusion Injury

1999 • 315 citations

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.

1982 • 293 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

2002 • 261 citations

Transgenic Mouse Model of Stunned Myocardium

2000 • 229 citations

Cardiac titin: an adjustable multi‐functional spring

2002 • 222 citations

Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats

1999 • 184 citations

Transient aggregation of ubiquitinated proteins during dendritic cell maturation

2002 • 176 citations

Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy

2004 • 175 citations

Cardiac Troponin I Gene Knockout

1999 • 149 citations

Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage

1998 • 145 citations

Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein

2002 • 137 citations

Adenoviral Gene Transfer of Phospholamban in Isolated Rat Cardiomyocytes

1997 • 122 citations

The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism

1986 • 122 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Amino acid and hormonal control of macromolecular turnover in perfused rat liver. Evidence for selective autophagy.

1987 • 99 citations

Myofilament Calcium Sensitivity and Cardiac Disease

2002 • 57 citations

p68RacGAP Is a Novel GTPase-activating Protein That Interacts with Vascular Endothelial Zinc Finger-1 and Modulates Endothelial Cell Capillary Formation

2004 • 31 citations

Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

2003 • 28 citations

Untitled

2002 • 25 citations

A Possible Explanation of Myxedema and Hypercholesterolemia in Hypothyroidism: Control of Lysosomal Hyaluronidase and Cholesterol Esterase by Thyroid Hormones

1981 • 21 citations