Adenoviral Gene Transfer of Phospholamban in Isolated Rat Cardiomyocytes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995 • 530 citations

Rate of Calcium Binding and Uptake in Normal Animal and Failing Human Cardiac Muscle: MEMBRANE VESICLES (RELAXING SYSTEM) AND MITOCHONDRIA

1969 • 521 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

1988 • 374 citations

Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.

1994 • 373 citations

Phospholamban: A Prominent Regulator of Myocardial Contractility

1996 • 346 citations

Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

1996 • 319 citations

Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus.

1994 • 285 citations

Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium.

1990 • 276 citations

Intracellular calcium homeostasis in cardiac myocytes.

1993 • 276 citations

Thyroid hormone-induced alterations in phospholamban protein expression. Regulatory effects on sarcoplasmic reticulum Ca2+ transport and myocardial relaxation.

1994 • 257 citations

Efficient gene transfer into myocardium by direct injection of adenovirus vectors.

1993 • 257 citations

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

1993 • 255 citations

In Vivo Echocardiographic Detection of Enhanced Left Ventricular Function in Gene-Targeted Mice With Phospholamban Deficiency

1995 • 241 citations

Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors.

1994 • 241 citations

Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes.

1995 • 229 citations

Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.

1991 • 201 citations

Differential Changes in Cardiac Phospholamban and Sarcoplasmic Reticular Ca ²⁺ -ATPase Protein Levels

1995 • 196 citations

Physiological Effects of Adenoviral Gene Transfer of Sarcoplasmic Reticulum Calcium ATPase in Isolated Rat Myocytes

1997 • 191 citations

Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.

1993 • 170 citations

Molecular and physiological alterations in murine ventricular dysfunction.

1994 • 160 citations

Identification of regions in the Ca(2+)-ATPase of sarcoplasmic reticulum that affect functional association with phospholamban.

1993 • 145 citations

Intracellular calcium transients and developed tension in rat heart muscle. A mechanism for the negative interval-strength relationship.

1985 • 142 citations

Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.

1994 • 132 citations

The max of the Ca2+-ATPase of Cardiac Sarcoplasmic Reticulum (SERCA2a) Is Not Altered by Ca2+/Calmodulin-dependent Phosphorylation or by Interaction with Phospholamban

1996 • 124 citations

Phospholamban Gene Dosage Effects in the Mammalian Heart

1996 • 118 citations

Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes

1996 • 118 citations

[4] Isolation of sarcoplasmic reticulum fractions referable to longitudinal tubules and functional terminal cisternae from rabbit skeletal muscle

1988 • 90 citations

Differential sensitivity to isoprenaline of troponin I and phospholamban phosphorylation in isolated rat hearts

1990 • 89 citations

Effects of thapsigargin and cyclopiazonic acid on twitch force and sarcoplasmic reticulum Ca2+ content of rabbit ventricular muscle.

1993 • 59 citations

Molecular Mechanism of Regulation of Ca2+ Pump ATPase by Phospholamban in Cardiac Sarcoplasmic Reticulum

1992 • 51 citations

Identification of a cis-Acting Sequence in the Human Plasminogen Activator Inhibitor Type-1 Gene That Mediates Transforming Growth Factor-β1 Responsiveness in Endothelium in Vivo

1996 • 43 citations

Isolation and characterization of purified sarcoplasmic reticulum membranes from isolated adult rat ventricular myocytes

1991 • 17 citations

Intracellular Free Calcium in Hypertrophy and Failure

1994 • 5 citations