Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons.

Arene Oxides: A New Aspect of Drug Metabolism

1974 • 1,043 citations

Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis

1974 • 739 citations

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

1976 • 483 citations

1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. V

1970 • 428 citations

Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.

1976 • 316 citations

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

1976 • 274 citations

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

1976 • 270 citations

Partial purification of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 270 citations

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

1977 • 263 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

1976 • 232 citations

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

1976 • 206 citations

Liver microsomal expoxide hydrase. Solubilization, purification, and characterization.

1975 • 170 citations

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

1975 • 168 citations

Mutagenicity and cytotoxicity of benzo(a)pyrene arene oxides, phenols, quinones, and dihydrodiols in bacterial and mammalian cells.

1976 • 161 citations

Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.

1977 • 147 citations

Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to the arene oxide pathway

1975 • 146 citations

Synthesis of (+-)-7.beta.,8.alpha.-dihydroxy-9.beta.,10.beta.-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a potential metabolite of the carcinogen benzo[a]pyrene with stereochemistry related to the antileukemic triptolides

1975 • 143 citations

Absolute configuration of a ribonucleic acid adduct formed in vivo by metabolism of benzo[a]pyrene

1977 • 141 citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. IV. Stereochemical considerations of dihydrodiol formation and dehyrogenation

1970 • 132 citations

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin.

1976 • 126 citations

Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

1976 • 110 citations

Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: Evidence for bay region activation of carcinogenic polycyclic hydrocarbons

1976 • 96 citations

Mutagenicity and cytotoxicity of benz[ a ]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides

1977 • 93 citations

Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.

1975 • 75 citations

Microsomal mixed-function oxidases and epoxide hydratase convert benzo[a]pyrene stereospecifically to optically active dihydroxydihydrobenzo[a]pyrenes

1976 • 52 citations

Optically active 4-substituted cis-1,2-diphenylethylene oxides and related 1,2-diphenylethane diols

1976 • 10 citations