The p53 Tumor Suppressor Inhibits Transcription of the TATA-less Mouse DP1 Promoter

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

Reporter constructs with low background activity utilizing the cat gene

1992 • 240 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

DP and E2F proteins: coordinating transcription with cell cycle progression

1994 • 205 citations

Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression

1995 • 185 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Mdm-2: “big brother” of p53

1997 • 175 citations

Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.

1996 • 172 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

1993 • 162 citations

Further characterisation of the p53 responsive element – identification of new candidate genes for trans-activation by p53

1997 • 160 citations

Inhibition of DNA Topoisomerase IIα Gene Expression by the p53 Tumor Suppressor

1997 • 154 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

The CDK₇-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

1997 • 152 citations

Transcriptional control by E2F

1995 • 147 citations

The Cat and Mouse Games That Genes, Viruses, and Cells Play

1997 • 138 citations

The role of E2F in the mammalian cell cycle

1993 • 136 citations

Inhibition of E2F Activity by the Cyclin-Dependent Protein Kinase Inhibitor p21 in Cells Expressing or Lacking a Functional Retinoblastoma Protein

1996 • 136 citations

p53 binds to the TATA-binding protein-TATA complex

1993 • 113 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene.

1996 • 95 citations

p53 Regulates the Minimal Promoter of the Human Topoisomerase II Gene

1996 • 91 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.

1996 • 83 citations

MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.

1995 • 76 citations

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

1996 • 74 citations

The retinoblastoma protein and its relatives

1995 • 62 citations

Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence

1996 • 48 citations

Overlapping domains on the p53 protein regulate its transcriptional activation and repression functions.

1994 • 45 citations

Structure and Expression of the ATFa Gene

1996 • 29 citations

p53 and SV40 T Antigen Bind to the Same Region Overlapping the Conserved Domain of the TATA-Binding Protein

1993 • 27 citations

TATA-less promoters of some Ets-family genes are efficiently repressed by wild-type p53.

1996 • 23 citations

p53 represses SV40 transcription by preventing formation of transcription complexes.

1995 • 17 citations

Genomic structure and developmental expression of the mouse cell cycle regulatory transcription factor DP1.

1996 • 12 citations

The regulation of p53-mediated transcription and the roles of hTAFII31 and mdm-2.

1994 • 9 citations