A new class of free radical scavengers reducing adriamycin mitochondrial toxicity

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

The Anthracycline Antineoplastic Drugs

1981 • 794 citations

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

1980 • 711 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

1983 • 634 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Lipid peroxide formation in microsomes. General considerations

1969 • 528 citations

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

1986 • 525 citations

Adriamycin—A Review

1975 • 458 citations

Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain.

1981 • 389 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Evidence of a specific complex between adriamycin and negatively-charged phospholipids

1980 • 307 citations

Adriamycin stimulated superoxide formation in submitochondrial particles

1977 • 256 citations

Adriamycin cardiotoxicity: a survey of 1273 patients.

1979 • 248 citations

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

1981 • 247 citations

Cardiolipin requirement by cytochrome oxidase and the catalytic role of phospholipid

1980 • 226 citations

Evidence of a complex between adriamycin derivatives and cardiolipin: Possible role in cardiotoxicity

1980 • 156 citations

Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin

1985 • 154 citations

Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment

1982 • 143 citations

Doxorubicin-induced congestive heart failure in adults

1985 • 127 citations

Experimental evaluation of anthracycline analogs.

1979 • 118 citations

Comparative Long-Term Study of the Toxicities of Free and Liposome-Associated Doxorubicin in Mice After Intravenous Administration<xref ref-type="fn" rid="FN1">2</xref>

1986 • 116 citations

Double integration of electron spin resonance spectra

1965 • 115 citations

Failure of the antioxidant vitamin E to protect against adriamycin-induced cardiotoxicity in the rabbit.

1980 • 97 citations

OH•-generation by adriamycin semiquinone and H2O2; An explanation for the cardiotoxicity of anthracycline antibiotics

1983 • 96 citations

Cardiotoxicity of antitumor agents

1984 • 94 citations

Doxorubicin-induced chronic cardiotoxicity and its protection by liposomal administration.

1982 • 85 citations

Invitro and invivo studies with adriamycin liposomes

1979 • 82 citations

Mechanism of inhibition of mitochondrial enzymatic complex I–III by adriamycin derivatives

1986 • 78 citations

Adriamycin: Energy metabolism and mitochondrial oxidations in the heart of treated rabbits

1976 • 77 citations

Effects of seven anthracyclin antibiotics on electrocardiogram and mitochondrial function of rat hearts

1975 • 73 citations

Mitochondrial membrane modifications induced by adriamycin-mediated electron transport

1983 • 72 citations

The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice

1979 • 66 citations

Prevention of doxorubicin myocardial toxicity in mice by reduced glutathione.

1986 • 63 citations

Effect of alpha-tocopherol on the cardiotoxicity of adriamycin in the rat.

1978 • 62 citations

A theoretical evaluation of the synergetic capto-dative stabilisation of free radicals

1980 • 56 citations

Usefulness of a free radical scavenger in preventing doxorubicin-induced heart failure in dogs

1985 • 39 citations

Effect of sulfhydryl-containing compounds on the antitumor effects of adriamycin

1980 • 36 citations

Effect of doxorubicin and rubidazone on respiratory function and Ca2+ transport in rat heart mitochondria

1979 • 34 citations

Abrogation of adriamycin-induced cardiotoxicity by selenium in rabbits.

1987 • 31 citations

In vivo and in vitro modifications of the mitochondrial membrane induced by 4' Epi-adriamycin

1986 • 26 citations

Damages of the mitochondrial membrane in adriamycin treated mice

1984 • 24 citations

Substituent effects on the formation of aminocarboxy-type capto-dative free radicals

1983 • 20 citations

The Effect of Vitamin E and Selenium on Doxorubicin (Adriamycin®) Induced Delayed Toxicity in Mice

1986 • 19 citations

Adriamycin and derivatives interaction with the mitochondrial membrane: O2 consumption and free radicals formation.

1984 • 17 citations

Mechanism of inhibition of mitochondrial enzymatic complex I–III by adriamycin derivatives

1986 • 15 citations

Captodative substituent effects—XV

1985 • 12 citations

Oxidation of 3,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3) with molecular oxygen. Generation of a persistent aminyl radical

1986 • 9 citations

ChemInform Abstract: CAPTODATIVE SUBSTITUENT EFFECTS ‐ XV. GENERALIZATION OF BRIDGED DEHYDRODIMERIZATION BY VARYING RADICOPHILES AND POLARITY OF ATTACKING RADICALS

1985 • 9 citations

Immunological modification of adriamycin cardiotoxicity.

1980 • 9 citations

ChemInform Abstract: SUBSTITUENT EFFECTS ON THE FORMATION OF AMINOCARBOXY‐TYPE CAPTO‐DATIVE FREE RADICALS

1984 • 1 citations