Structure-based and combinatorial search for new RNA-binding drugs

The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

1994 • 975 citations

Structure of the A Site of Escherichia coli 16 S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

1996 • 782 citations

The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein

1995 • 360 citations

Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

1994 • 286 citations

Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA

1997 • 275 citations

Paromomycin binding induces a local conformational change in the A-site of 16 s rRNA

1998 • 269 citations

RNA Sequence Determinants for Aminoglycoside Binding to an A-site rRNA Model Oligonucleotide

1996 • 252 citations

Structural basis of RNA folding and recognition in an AMP–RNA aptamer complex

1996 • 246 citations

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

1997 • 241 citations

Molecular Recognition in the FMN – RNA Aptamer Complex

1996 • 217 citations

Direct Observation of Aminoglycoside−RNA Interactions by Surface Plasmon Resonance

1997 • 206 citations

Solution structure of an ATP-binding RNA aptamer reveals a novel fold.

1996 • 195 citations

Probing the Specificity of Aminoglycoside−Ribosomal RNA Interactions with Designed Synthetic Analogs

1998 • 190 citations

Structural Basis of Ligand Discrimination by Two Related RNA Aptamers Resolved by NMR Spectroscopy

1996 • 179 citations

Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA 1 1Edited by J. Karn

1998 • 176 citations

Rapid Combinatorial Synthesis of Aminoglycoside Antibiotic Mimetics: Use of a Polyethylene Glycol-Linked Amine and a Neamine-Derived Aldehyde in Multiple Component Condensation as a Strategy for the Discovery of New Inhibitors of the HIV RNA Rev Responsive Element

1996 • 173 citations

A good antisense molecule is hard to find

1998 • 171 citations

Specificity of Aminoglycoside Binding to RNA Constructs Derived from the 16S rRNA Decoding Region and the HIV-RRE Activator Region

1997 • 160 citations

Binding of Neomycin to the TAR Element of HIV-1 RNA Induces Dissociation of Tat Protein by an Allosteric Mechanism

1998 • 156 citations

Solution structure of the tobramycin–RNA aptamer complex

1998 • 154 citations

Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex

1997 • 138 citations

Flexible Docking and Design

1995 • 137 citations

Inhibition of an HIV-1 Tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics

1995 • 134 citations

A New Class of HIV-1 Tat Antagonist Acting through Tat−TAR Inhibition

1998 • 133 citations

Selection of RNA-binding peptides in vivo

1996 • 128 citations

RNA Molecules That Specifically and Stoichiometrically Bind Aminoglycoside Antibiotics with High Affinities

1996 • 127 citations

A Library Approach to the Discovery of Small Molecules That Recognize RNA: Use of a 1,3-Hydroxyamine Motif as Core

1998 • 109 citations

A Structural Model for the HIV-1 Rev–RRE Complex Deduced from Altered-Specificity Rev Variants Isolated by a Rapid Genetic Strategy

1996 • 101 citations

Electrostatic Interactions in RNA Aminoglycosides Binding

1997 • 98 citations

Structure-Based Discovery of Ligands Targeted to the RNA Double Helix

1997 • 71 citations

Antibiotic inhibition of RNA catalysis: neomycin B binds to the catalytic core of the td group I intron displacing essential metal ions 1 1Edited by M. Yaniv

1998 • 70 citations

Modulation of the rev-RRE interaction by aromatic heterocyclic compounds

1997 • 52 citations

RNA Structure Comes of Age

1997 • 47 citations

Atomic solvation parameters in the analysis of protein‐protein docking results

1995 • 47 citations

rRNA Chemical Groups Required for Aminoglycoside Binding

1998 • 46 citations

Structure of a stereoregular phosphorothioate DNA/RNA duplex

1998 • 44 citations

Specific RNA binding proteins constructed from zinc fingers

1998 • 43 citations

Modeling RNA−Ligand Interactions: The Rev-Binding Element RNA−Aminoglycoside Complex

1998 • 41 citations

A translational repression assay procedure (TRAP) for RNA–protein interactions in vivo

1998 • 38 citations

Design and analysis of molecular motifs for specific recognition of RNA

1997 • 37 citations

Simple Aminols as Aminoglycoside Surrogates

1998 • 36 citations

Discovery of selective, small-molecule inhibitors of RNA complexes—II. Self-splicing group I intron ribozyme

1997 • 27 citations

Synthesis of novel polyazadipyridinocyclophane scaffolds and their application for the generation of libraries

1998 • 25 citations

Antisense Binding Enhanced by Tertiary Interactions: Binding of Phosphorothioate and N3‘→P5‘ Phosphoramidate Hexanucleotides to the Catalytic Core of a Group I Ribozyme from the Mammalian Pathogen Pneumocystis carinii

1998 • 17 citations

Inhibition of Self-Splicing Group I Intron RNA: High-Throughput Screening Assays

1996 • 17 citations