Combined Antitumor Effect of Suramin Plus Irradiation in Human Prostate Cancer Cells: The Role of Apoptosis

Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

1979 • 1,595 citations

Isolation of a human prostate carcinoma cell line (DU 145)

1978 • 1,176 citations

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1983 • 921 citations

Radiation Biology in Cancer Research

1980 • 782 citations

Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 • 730 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

1989 • 417 citations

Adaptation versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma.

1981 • 382 citations

Radical Surgery Versus Radiotherapy for Adenocarcinoma of the Prostate

1982 • 363 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate

1987 • 256 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

Apoptosis in irradiated murine tumors.

1991 • 199 citations

Effects of Caffeine on Radiation-Induced Phenomena Associated with Cell-Cycle Traverse of Mammalian Cells

1974 • 191 citations

Programmed death of nonproliferating androgen-independent prostatic cancer cells.

1991 • 159 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

Apoptosis in Irradiated Murine Tumors

1991 • 150 citations

Suramin Blockade of Insulinlike Growth Factor I-Stimulated Proliferation of Human Osteosarcoma Cells

1990 • 149 citations

Radiation-induced apoptosis in a murine T-cell hybridoma.

1992 • 116 citations

Non-hormone chemotherapy for prostate cancer: principles of treatment and application to the testing of new drugs.

1988 • 111 citations

“Thymineless” death in androgen-independent prostatic cancer cells

1989 • 101 citations

Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase agent, on protein kinase C. Differential activation and inhibition of protein kinase C isozymes.

1990 • 88 citations

Effect of Suramin on Human Prostate Cancer Cells in Vitro

1991 • 75 citations

A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer

1988 • 74 citations

The Effects of Basic Fibroblast Growth Factor and suramin on Cell Motility and Growth of Rat Prostate Cancer Cells

1991 • 70 citations

Suramin inhibits the growth of human rhabdomyosarcoma by interrupting the insulin-like growth factor II autocrine growth loop.

1992 • 61 citations

Inhibition of Prostatic Tumor Cell Proliferation by Suramin: Alterations in TGF Alpha-Mediated Autocrine Growth Regulation and Cell Cycle Distribution

1991 • 60 citations

Suramin for prostatic cancer: A phase I/II study in advanced extensively pretreated disease

1990 • 57 citations

Antiproliferative effects of suramin on androgen responsive tumour cells

1990 • 50 citations

Prostate Cancer: The Magnitude of the Problem in the United States

1988 • 50 citations

Influence of the H-ras oncogene on radiation responses of a rat rhabdomyosarcoma cell line.

1992 • 46 citations

Endocrine changes after diethylstilbestrol therapy Effects on prostatic neoplasm and pituitary-gonadal axis

1976 • 45 citations

Cytostatic Effects of Suramin on Prostate Cancer Cells Cultured from Primary Tumors

1991 • 44 citations

Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases.

1990 • 44 citations

Inhibition of Breast Cancer Growth by Suramin

1992 • 44 citations

Disruption of cellular energy balance by suramin in intact human prostatic carcinoma cells, a likely antiproliferative mechanism.

1991 • 40 citations

Suramin inhibits binding and degradation of platelet-derived growth factor in arterial smooth muscle cells but does not interfere with autocrine stimulation of DNA synthesis

1989 • 27 citations

Suramin blocks intracellular Ca2+ release and growth factor-induced increases in cytoplasmic free Ca2+ concentration

1990 • 20 citations

Differential effects of growth factor antagonists on neoplastic and normal prostatic cells

1990 • 18 citations

Effect of radiation combined withhyperthermia on human prostatic carcinoma cell lines in culture

1991 • 13 citations

Irradiation and/or surgery

1984 • 8 citations