Oltipraz: A laboratory and clinical review

Chemoprevention of Cancer

2008 • 1,269 citations

Down-Regulation of the Antitumor Immune Response

1985 • 676 citations

Diet in the Epidemiology of Cancer of the Colon and Rectum<xref ref-type="fn" rid="FN2">2</xref>

1978 • 423 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Functions of Glutathione in Liver and Kidney

1978 • 352 citations

Case‐control study of dietary etiological factors: The Melbourne colorectal cancer study

1987 • 338 citations

Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population

1985 • 280 citations

Aryl Hydrocarbon Hydroxylase Induction in Rat Tissues by Naturally Occurring Indoles of Cruciferous Plants<xref ref-type="fn" rid="fn2">2</xref>

1975 • 246 citations

Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.

1987 • 242 citations

Stimulatory effect of brussels sprouts and cabbage on human drug metabolism

1979 • 242 citations

A case-control study of large bowel cancer in Japan.

1980 • 214 citations

Effects of Peptide YY and Neuropeptide Y on Gastric Emptying in Man

1984 • 166 citations

Biochemical effects of dithiolthiones

1986 • 161 citations

Modification of aflatoxin B₁ binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione

1985 • 150 citations

Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithioI-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard

1986 • 144 citations

Chemoprotective Effects of Two Dithiolthiones and of Butylhydroxyanisole Against Carbon Tetrachloride and Acetaminophen Toxicity

2007 • 142 citations

Modification by beet and cabbage diets of aflatoxin B1-induced rat plasma α-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine

1982 • 135 citations

Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol.

1991 • 100 citations

Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer l,2-dithiole-3-thione

1992 • 98 citations

Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.

1990 • 87 citations

Screening for chemopreventive (anticarcinogenic) compounds in rodents

1992 • 82 citations

Molecular dosimetry of urinary aflatoxin-N⁷-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by l,2-dithiole-3-thione in rats

1992 • 81 citations

Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat

1988 • 74 citations

Studies on the detoxication of microsomally-activated aflatoxin B₁ by glutathione and glutathione transferases ^{in vitro}

1985 • 73 citations

Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats

1991 • 63 citations

Effects of oltipraz, BHA, ADT and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice

1986 • 63 citations

Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung

1992 • 59 citations

1, 2-Dithiol-3-thione analogs: effects on NAD(P)H: quinone reductase and glutathione levels in murine hepatoma cells

1986 • 46 citations

Functions of Glutathione in Drug Metabolism

1978 • 44 citations

Factors influencing the induction of DNA single strand breaks in rats by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1989 • 38 citations

Clinical pharmacology studies of Oltipraz — A potential chemopreventive agent

1992 • 32 citations

Oltipraz—Antischistosomal Efficacy in Sudanese Infected with Schistosoma Mansoni *

1982 • 32 citations

Assessment of 35972 RP (oltipraz) a new antischistosomal drug against Schistosoma haematobium, Schistosoma mansoni, and Schistosoma intercalatum.

1980 • 31 citations

Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro.

1991 • 28 citations

Effect of Oltipraz [5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on Azoxymethane-Induced Biochemical Changes Related to Early Colon Carcinogenesis in Male F344 Rats

1991 • 25 citations

Diet-controlled blood levels of oltipraz in healthy male subjects

1984 • 23 citations

THE CHEMISTRY OF THE 1,2-DITHIOLE RING

1966 • 21 citations

Dose-ranging clinical trial with oltipraz in schistosomiasis mansoni.

1982 • 20 citations

Inhibition of Aflatoxin-Induced Serum -Fetoprotein in Rats Fed Cauliflower

1979 • 20 citations

Chemoprotection by Inducers of Electrophile Detoxication Enzymes

1993 • 18 citations

Inhibitors of Carcinogenesis

1990 • 15 citations

1,2-Dithiol-3-thione and dithioester analogues: potential radioprotectors

1990 • 15 citations

Die Isolierung und Identifizierung organischer Polysulfide aus Kraut und ihre Beziehung zum Brassica Faktor

1957 • 10 citations

Effect of Cysteine on Oltipraz Blood Levels in Green Monkeys <i>(Cercopithecus aethiops)</i>

1984 • 5 citations