Functions of Glutathione in Drug Metabolism

Glutathione peroxidase activity in selenium-deficient rat liver

1976 • 3,413 citations

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

1974 • 3,074 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Acetaminophen-induced Hepatic Necrosis

1974 • 1,021 citations

Glutathione: Metabolism and function

1978 • 971 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen.

1957 • 399 citations

The role of H2O2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors

1973 • 271 citations

Formaldehyde Dehydrogenase from Human Liver

1974 • 217 citations

Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase

1977 • 206 citations

Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450

1977 • 187 citations

The steady state level of catalase compound I in isolated hemoglobin‐free perfused rat liver

1970 • 164 citations

FORMALDEHYDE DEHYDROGENASE, A GLUTATHIONE-DEPENDENT ENZYME SYSTEM

1955 • 159 citations

The role of methionine in glutathione biosynthesis by isolated hepatocytes

1977 • 159 citations

Metabolic activation and hepatotoxicity

1979 • 158 citations

Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

1978 • 149 citations

THE EFFECT OF pH UPON THE EQUILIBRIA OF CATALASE COMPOUNDS

1952 • 108 citations

Purification and Properties of S-Formylglutathione Hydrolase from Human Liver

1974 • 98 citations

Heme occupancy of catalase in hemoglobin-free perfused rat liver and of isolated rat liver catalase

1973 • 95 citations

Glutathione Efflux from Perfused Rat Liver after Phenobarbital Treatment, during Drug Oxidations, and in Selenium Deficiency

1978 • 94 citations

Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction

1973 • 90 citations

The Disposition of Formaldehyde and Formate Arising from Drug N-Demethylations Dependent on Cytochrome P-450 in Hepatocytes and in Perfused Rat Liver

1978 • 80 citations

Metabolic activation and hepatotoxicity

1978 • 62 citations

A comparison of rat and human liver formaldehyde dehydrogenase

1971 • 58 citations

Metabolic activation and hepatotoxicity

1978 • 58 citations

Hepatic microsomal dealkylations. Inhibition by a tyrosine-copper (II) complex provided with superoxide dismutase activity.

1977 • 55 citations

Different contribution of rat liver microsomal pigments in the formation of superoxide anions and hydrogen peroxide during development

1977 • 52 citations