Stimulation by prostaglandin E2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1990 • 600 citations

Small GTP-Binding Proteins

1992 • 526 citations

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

1993 • 318 citations

High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide.

1981 • 189 citations

Tension in secretory granule membranes causes extensive membrane transfer through the exocytotic fusion pore.

1990 • 148 citations

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

1977 • 144 citations

Presence of three pertussis toxin substrates and G_oα immunoreactivity in both plasma and granule membranes of chromaffin cells

1987 • 138 citations

[17] Isolation and characterization of Golgi apparatus and membranes from rat liver

1974 • 138 citations

Lipoxygenase Pathway in Islet Endocrine Cells. OXIDATIVE METABOLISM OF ARACHIDONIC ACID PROMOTES INSULIN RELEASE

1983 • 125 citations

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet .beta.-cells

1993 • 123 citations

Exocytosis in chromaffin cells. Possible involvement of the heterotrimeric GTP-binding protein G(o)

1993 • 122 citations

Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins

1993 • 121 citations

Temporal Relationship between Use of NSAIDs, Including Selective COX-2 Inhibitors, and Cardiovascular Risk

2006 • 117 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

G Proteins and Modulation of Insulin Secretion

1991 • 93 citations

Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).

1991 • 90 citations

Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase

1989 • 87 citations

Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy.

1989 • 87 citations

Subcellular localization of Gi alpha in human neutrophils.

1988 • 85 citations

Exogenous Arachidonic Acid Promotes Insulin Release From Intact or Permeabilized Rat Islets by Dual Mechanisms: Putative Activation of Ca2+ Mobilization and Protein Kinase C

1988 • 80 citations

Insulin Secretion and cAMP Metabolism in HIT Cells: Reciprocal and Serial Passage-Dependent Relationships

1989 • 78 citations

Inhibition of In Vivo Insulin Secretion by Prostaglandin E1

1974 • 78 citations

Inhibition of Prostaglandin E Synthesis Augments Glucose-induced Insulin Secretion in Cultured Pancreas

1981 • 72 citations

Arachidonic acid metabolism in isolated pancreatic islets

1984 • 72 citations

Receptor-Mediated Adenylate Cyclase—Coupled Mechanism for PGE2 Inhibition of Insulin Secretion in HIT Cells

1987 • 72 citations

Molecular Biology of Diabetes

1994 • 69 citations

ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS

1969 • 67 citations

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules

1982 • 67 citations

Direct Interactions of Mastoparan and Compound 48/80 with GTP-Binding Proteins1

1991 • 54 citations

Arachidonic acid metabolite regulation of insulin secretion

1986 • 49 citations

Effect of in Vivo Pretreatment of Rats with a New Protein Purified fromBordetellapertussis onin VitroSecretion of Insulin: Role of Calcium

1979 • 45 citations

G-Proteins and Hormonal Inhibition of Insulin Secretion From HIT-T15 Cells and Isolated Rat Islets

1992 • 41 citations

Pertussis Toxin–Sensitive G Protein Mediation of PGE2 Inhibition of cAMP Metabolism and Phasic Glucose-Induced Insulin Secretion in HIT Cells

1989 • 41 citations

Secretory granules

1984 • 38 citations

Studies on proinsulin and proglucagon biosynthesis and conversion at the subcellular level: I. Fractionation procedure and characterization of the subcellular fractions

1977 • 36 citations

Acid Phosphatase Activity in Secretory Granules of Pancreatic Beta Cells of Normal Rats

1971 • 34 citations

The purification of a Rap1 GTPase-activating protein from bovine brain cytosol.

1992 • 33 citations

Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus

1992 • 33 citations

Arachidonic Acid Metabolism and Insulin Secretion by Isolated Human Pancreatic Islets

1988 • 33 citations

Arachidonic acid and its metabolites: Evolving roles as transmembrane signals for insulin release

1988 • 32 citations

Evidence for G proteins in rat parotid plasma membranes and secretory granule membranes

1992 • 29 citations

GTP-binding Proteins in the Control of Exocytosis

1988 • 27 citations

Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets

1986 • 26 citations

In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide

1978 • 20 citations

Immunological characterization of the guanine-nucleotide binding proteins Gi and Go in rat islets of Langerhans

1992 • 18 citations

Tissue and subcellular distributions of an inhibitory GDPGTP exchange protein (GDI) for smg p25A by use of its antibody

1991 • 17 citations

Phospholipid methyltransferase activity in pancreatic islets: Activation by calcium

1985 • 16 citations

A unique control mechanism in the regulation of insulin secretion. Secretagogue-induced somatostatin receptor recruitment.

1985 • 16 citations

The role and mechanism of the GTP-binding protein GE in the control of regulated exocytosis.

1990 • 11 citations

Adrenergic inhibition of insulin secretion involves pertussis toxin-sensitive and -insensitive mechanisms

1992 • 9 citations

Galanin-Stimulated High-Affinity GTPase Activity in Plasma Membranes From RINm5F Cells

1993 • 9 citations

Immunoprecipitation of a pertussis toxin substrate of the Go family from rat islets of Langerhans

1992 • 3 citations