Extrathymic Pathways of T‐Cell Differentiation: A Primitive and Fundamental Immune System

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

1987 • 515 citations

Effect of Hormones on Lymphatic Tissue

1952 • 512 citations

Successful small-bowel/liver transplantation

1990 • 459 citations

The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

1978 • 422 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Reversal of transplantation immunity by liver grafting

1981 • 278 citations

An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.

1992 • 270 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

1991 • 262 citations

Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma

1989 • 233 citations

Expression of Murine CD1 on Gastrointestinal Epithelium

1990 • 231 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.

1988 • 227 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

1992 • 186 citations

The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse.

1972 • 174 citations

Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.

1990 • 173 citations

Details of an isolation method for hepatic lymphocytes in mice

1992 • 169 citations

Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.

1989 • 168 citations

Expression of the thymus leukemia antigen in mouse intestinal epithelium.

1990 • 161 citations

Estrogen administration activates extrathymic T cell differentiation in the liver.

1992 • 153 citations

The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria.

1991 • 145 citations

Analysis of HLA-G mRNA in human placental and extraplacental membrane cells by in situ hybridization.

1991 • 144 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

Influence of collection and separation of blood samples on plasma IL-1, IL-6 and TNF-α concentrations

1992 • 136 citations

Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice.

1992 • 130 citations

The fate of CD4-8- T cell receptor-alpha beta+ thymocytes.

1991 • 129 citations

Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver.

1991 • 124 citations

Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells.

1991 • 112 citations

Accumulation of CD16⁻CD56⁺ natural killer cells with high affinity interleukin 2 receptors in human early pregnancy decidua

1991 • 112 citations

Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.

1991 • 109 citations

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.

1991 • 107 citations

Ontogeny and development of extrathymic T cells in mouse liver.

1992 • 100 citations

The glycolipid asialo GM1 as a new differentiation antigen of fetal thymocytes.

1980 • 90 citations

Age-related variation in the proportion and activity of murine liver natural killer cells and their cytotoxicity against regenerating hepatocytes.

1988 • 85 citations

Evidence for the expression of non-HLA-A,-B,-C class I genes in the human fetal liver.

1992 • 77 citations

Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts.

1990 • 75 citations

Predominant appearance of γ/δ T lymphocytes in the liver of mice after birth

1991 • 72 citations

Natural killer (NK) cell activity of first trimester human decidua

1989 • 72 citations

Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune mice.

1991 • 67 citations

Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor.

1991 • 65 citations

HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A. Implications for the evolution of the HLA-A-related genes.

1992 • 65 citations

Evidence for extrathymic development of TNK cells. NK1+ CD3+ cells responsible for acute marrow graft rejection are present in thymus-deficient mice.

1992 • 64 citations

COMBINED SMALL BOWEL AND LIVER TRANSPLANTATION IN THE RAT

1991 • 58 citations

Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow.

1989 • 55 citations

Failure of T cell receptor Vβ negative selection in murine intestinal intra-epithelial lymphocytes

1991 • 55 citations

Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells

1991 • 53 citations

T cell antigen receptor expression by subsets of Ly-2-L3T4- (CD8-CD4-) thymocytes.

1988 • 51 citations

Thymic involution and thymocyte phenotypic alterations induced by murine mammary adenocarcinomas.

1989 • 50 citations

Intrathymic selection of murine TCRαβ⁺CD4⁻CD8⁻ thymocytes

1990 • 50 citations

Production of interleukin 6 from human liver cell lines: production of interleukin 6 is not concurrent with the production of alpha-fetoprotein.

1990 • 45 citations

Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.

1992 • 43 citations

CD4⁻CD8⁻ thymocytes that express the T cell receptor may have previously expressed CD8

1990 • 41 citations

<b>EXTRATHYMIC DIFFERENTIATION OF T LYMPHOCYTES AND ITS BIOLOGICAL </b><b>FUNCTION </b>

1992 • 40 citations

Characterization of T cells infiltrating the heart in rats with experimental autoimmune myocarditis. Their similarity to extrathymic T cells in mice and the site of proliferation.

1993 • 39 citations

CD4-CD8- T cell receptor alpha beta T cells: generation of an in vitro major histocompatibility complex class I specific cytotoxic T lymphocyte response and allogeneic tumor rejection.

1991 • 33 citations

Activation of extrathymic T cells in the liver during liver regeneration following partial hepatectomy.

1993 • 31 citations

Regulation of Interleukin‐6 Production in Human Fetal Kupffer Cells

1991 • 31 citations

Rat thymic epithelial cells in culture constitutively secrete IL-1 and IL-6

1991 • 28 citations

Human T cell responses to IL-1 and IL-6 are dependent on signals mediated through CD2.

1991 • 27 citations

Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation

1992 • 25 citations

The Liver and the Hematolymphoid System: I. The Regulation of Nylon-Passed Spleen Cell Proliferation by Active Factors Released From Syngeneic Nonparenchymal Liver Cells

1991 • 21 citations

Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy.

1992 • 18 citations

L3T4+ T cells induce hepatic lesions resembling primary biliary cirrhosis in mice with graft-versus-host reactions due to major histocompatibility complex class II disparity

1991 • 18 citations

In vivo and in vitro repertoire of CD3⁺CD4−CD8–thymocytes

1990 • 17 citations

T cell recruitment from the thymus to the spleen in tumor-bearing mice

1986 • 17 citations

Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain.

1991 • 16 citations

Developmental and tissue-specific expression of the Q5 k gene

1991 • 16 citations

HLA-J, A SECOND INACTIVATED CLASS I HLA GENE RELATED TO HLA-G AND HLA-A

1992 • 15 citations

T-cell recruitment from the thymus to the spleen in tumor bearing mice: phenotypical alteration and recruitment of thymocytes raised in a tumor bearing state.

1987 • 15 citations

Relative resistance of intermediate TCR cells to anti-CD3 mAb in mice in vivo and their partial functional characterization

1992 • 13 citations

Characterization of constitutive and strain-dependent subsets of CD45RA⁺ cells in the thymus

1992 • 9 citations

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