Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

2002 • 3,174 citations

Neurobiology of Depression

2002 • 3,057 citations

Premature ageing in mice expressing defective mitochondrial DNA polymerase

2004 • 2,561 citations

DNA Repair and Mutagenesis

2005 • 2,262 citations

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 • 2,025 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

Transient expression of doublecortin during adult neurogenesis

2003 • 1,485 citations

Milestones of neuronal development in the adult hippocampus

2004 • 1,389 citations

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

2006 • 992 citations

Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment

2002 • 881 citations

Neurogenesis may relate to some but not all types of hippocampal‐dependent learning

2002 • 854 citations

Neurotoxicity associated with dual actions of homocysteine at the N -methyl- <scp>d</scp> -aspartate receptor

1997 • 830 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

2000 • 765 citations

The neurotrophin hypothesis for synaptic plasticity

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Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

2004 • 722 citations

The Regulation of Reactive Oxygen Species Production during Programmed Cell Death

1998 • 719 citations

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial

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Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.

1981 • 678 citations

Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

2004 • 638 citations

Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis

2003 • 638 citations

Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease

2002 • 638 citations

Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli

2003 • 623 citations

DETERMINATION OF CATECHOLAMINES IN RAT BRAIN PARTS BY REVERSE‐PHASE ION‐PAIR LIQUID CHROMATOGRAPHY

1978 • 586 citations

Vitamin dificiencies and neural tube defects.

1976 • 580 citations

Homocysteine, folate, methylation, and monoamine metabolism in depression

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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

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Neural tube defects and folate: case far from closed

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Behavioral Phenotypes of Disc1 Missense Mutations in Mice

2007 • 527 citations

Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice

2003 • 475 citations

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

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Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions

2005 • 375 citations

Experimental nutritional folate deficiency in man.

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hUNG2 Is the Major Repair Enzyme for Removal of Uracil from U:A Matches, U:G Mismatches, and U in Single-stranded DNA, with hSMUG1 as a Broad Specificity Backup

2002 • 330 citations

Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects

2006 • 327 citations

Uracil-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication

2000 • 315 citations

Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activation

2003 • 311 citations

Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task

2002 • 283 citations

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

2006 • 283 citations

Methotrexate-induced misincorporation of uracil into DNA

1980 • 276 citations

The Actin-Severing Protein Gelsolin Modulates Calcium Channel and NMDA Receptor Activities and Vulnerability to Excitotoxicity in Hippocampal Neurons

1997 • 269 citations

High frequency mutagenesis by a DNA methyltransferase

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Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid

1980 • 257 citations

Relation of Higher Folate Intake to Lower Risk of Alzheimer Disease in the Elderly

2007 • 237 citations

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

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Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine

2003 • 233 citations

Mild Cerebral Ischemia Induces Loss of Cyclin-Dependent Kinase Inhibitors and Activation of Cell Cycle Machinery before Delayed Neuronal Cell Death

2001 • 225 citations

Folic acid, ageing, depression, and dementia

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Diminished adult neurogenesis in the marmoset brain precedes old age

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A Comparison of Biochemical Indices of 5‐Hydroxytryptaminergic Neuronal Activity Following Electrical Stimulation of the Dorsal Raphe Nucleus

1986 • 211 citations

Folate, Vitamin B ₆ , and B ₁₂ Intakes in Relation to Risk of Stroke Among Men

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Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei

2005 • 176 citations

Exposure to lead (Pb) and the developmental origin of oxidative DNA damage in the aging brain

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Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses

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Neuronal configurations in lateral and basolateral amygdala

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Folate Deficiency Inhibits the Proliferation of Primary Human CD8+ T Lymphocytes In Vitro

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Folate deficiency in depressive illness.

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Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice

1995 • 159 citations

Plasma total homocysteine and memory in the elderly: The Hordaland Homocysteine study

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Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease

2005 • 150 citations

Folate Deficiency in Depressive Illness

1970 • 150 citations

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

2003 • 148 citations

Vmat2Heterozygous Mutant Mice Display a Depressive-Like Phenotype

2007 • 145 citations

Simultaneous Determination of Serotonin, 5‐Hydroxyindoleacetic Acid, 3,4‐Dihydroxyphenylacetic Acid and Homovanillic Acid by High Performance Liquid Chromatography with Electrochemical Detection

1982 • 141 citations

DNA damage, repair, and antioxidant systems in brain regions: a correlative study

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The effect of methotrexate on levels of dUTP in animal cells.

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State of the art of the neurotrophin hypothesis in psychiatric disorders: implications and limitations

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Impaired Spatial Performance in Rats with Retrosplenial Lesions: Importance of the Spatial Problem and the Rat Strain in Identifying Lesion Effects in a Swimming Pool

2002 • 115 citations

Nei Deficient Escherichia coli Are Sensitive to Chromate and Accumulate the Oxidized Guanine Lesion Spiroiminodihydantoin

2005 • 114 citations

Serum Folate, Vitamin B12, and Homocysteine in Major Depressive Disorder, Part 1

2004 • 111 citations

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

2004 • 109 citations

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

2004 • 108 citations

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

2004 • 102 citations

Folate deficiency inhibits proliferation of adult hippocampal progenitors

2005 • 96 citations

Anxious and Hyperactive Phenotype Following Brief Ischemic Episodes in Mice

2005 • 95 citations

Effect of folic acid and vitamin B₁₂ deficiencies on 5‐hydroxyindoleacetic acid in human cerebrspinal fluid

1982 • 94 citations

Kainic acid-induced changes of serotonin and dopamine metabolism in the striatum and substantia nigra of the rat

1981 • 90 citations

Morphological alterations in the amygdala and hippocampus of mice during ageing

2002 • 84 citations

Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation

2003 • 82 citations

Serum Folate, Vitamin B12, and Homocysteine in Major Depressive Disorder, Part 2

2004 • 69 citations

Induced Spreading Depression Activates Persistent Neurogenesis in the Subventricular Zone, Generating Cells With Markers for Divided and Early Committed Neurons in the Caudate Putamen and Cortex

2005 • 66 citations

Folate and brain function in the elderly

2004 • 63 citations

Folate Deficiency Increases Postischemic Brain Injury

2004 • 63 citations

Hyperhomocysteinemia in <scp>l</scp>‐dopa treated Parkinson's disease patients: effect of cobalamin and folate administration

2005 • 62 citations

Dysexecutive Syndrome After Mild Cerebral Ischemia?

2003 • 60 citations

Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment

2006 • 59 citations

Minireview

1998 • 58 citations

Behavioral effects of prenatal exposure to nicotine in guinea pigs.

1982 • 58 citations

Melatonin is protective in necrotic but not in caspasedependent, free radical‐independent apoptotic neuronal cell death in primary neuronal cultures

2000 • 57 citations

Suppression of Uracil-DNA Glycosylase Induces Neuronal Apoptosis

2004 • 56 citations

Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype

2001 • 56 citations

Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat

1995 • 53 citations

N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency

2005 • 53 citations

Nestin-Expressing Cells Divide and Adopt a Complex Electrophysiologic Phenotype after Transient Brain Ischemia

2005 • 51 citations

Behavioural and Morphological Outcome of Mild Cortical Contusion Trauma of the Rat Brain: Influence of NMDA-Receptor Blockade

1999 • 44 citations

Comparative behavioral changes in postpubertal rats after neonatal excitotoxic lesions of the ventral hippocampus and the prefrontal cortex

2005 • 43 citations

Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats

2002 • 41 citations

Attenuation of age-dependent oxidative damage to DNA and protein in brainstem of Tg Cu/Zn SOD mice

1998 • 39 citations

Measurement of glutathione oxidation and 8-hydroxy-2′-deoxyguanosine accumulation in the gerbil hippocampus following global ischemia

2000 • 28 citations

Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation

2004 • 19 citations