Folate Deficiency Inhibits the Proliferation of Primary Human CD8+ T Lymphocytes In Vitro

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

1997 • 1,437 citations

The Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine Concentrations

1999 • 1,141 citations

Present Knowledge in Nutrition.

1954 • 1,086 citations

Folate and Carcinogenesis: An Integrated Scheme

2000 • 936 citations

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes

2000 • 782 citations

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

1999 • 542 citations

Moderate Folate Depletion Increases Plasma Homocysteine and Decreases Lymphocyte DNA Methylation in Postmenopausal Women

1998 • 493 citations

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.

1998 • 453 citations

Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations

2000 • 440 citations

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

2001 • 392 citations

Prevalence of Micronutrient Malnutrition Worldwide

2002 • 359 citations

Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans

1997 • 334 citations

Are vitamin and mineral deficiencies a major cancer risk?

2002 • 287 citations

Effect of food fortification on folic acid intake in the United States

2003 • 283 citations

Micronutrients and HIV-1 disease progression

1995 • 263 citations

Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment

1999 • 255 citations

Abnormal T-cell subset proportions in vitamin-A-deficient children

1993 • 182 citations

Impact of Extracellular Folate Levels on Global Gene Expression

2001 • 163 citations

The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro.

2001 • 157 citations

Present Knowledge in Nutrition, 7th ed

1997 • 147 citations

Immunobiology of mild micronutrient deficiencies

2001 • 126 citations

Folate status and the immune system.

1991 • 120 citations

Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats

1997 • 110 citations

Effects of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women

1998 • 107 citations

Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro

2001 • 106 citations

Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-κB in human Hep G2 cells

2001 • 103 citations

Folate Deficiency Induces a Cell Cycle-Specific Apoptosis in HepG2 Cells

1999 • 98 citations

Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison

2003 • 94 citations

Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption

1989 • 80 citations

Micronutrients and immune function: some recent developments.

1997 • 77 citations

Folate and carcinogenesis: developing a unifying hypothesis

2000 • 76 citations

Apoptosis mediates and thymidine prevents erythroblast destruction in folate deficiency anemia.

1994 • 74 citations

Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism

2000 • 70 citations

Analysis of Uracil in DNA by Gas Chromatography-Mass Spectrometry

1994 • 66 citations

Cytokines and Cancer

1998 • 65 citations

Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes

2004 • 51 citations

Nutritional folate-deficiency in Chinese hamster ovary cells

1990 • 48 citations

Mechanism of deoxycytidine rescue of thymidine toxicity in human T-leukemic lymphocytes.

1980 • 44 citations

Close Link between CD4⁺and CD8⁺T Cell Proliferation Defects in Patients with Human Immunodeficiency Virus Disease and Relationship to Extended Periods of CD4⁺Lymphopenia

2002 • 44 citations

Effects of dietary n-6 and n-3 fatty acids and vitamin E on the immune response of healthy geriatric dogs

2003 • 44 citations

Effects of 10-T Static Magnetic Field on Human Peripheral Blood Immune Cells

2003 • 44 citations

Severe Folate Deficiency Impairs Natural Killer Cell–Mediated Cytotoxicity in Rats

2002 • 41 citations

PHA-induced cell proliferation rescues human peripheral blood lymphocytes from X-ray-induced apoptosis

2001 • 39 citations

Immunosuppression and cancer.

1992 • 34 citations

Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis

1999 • 31 citations

Nutritional folate deficiency in chinese hamster ovary cells I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors

1989 • 28 citations

Lymphocyte subsets as prognostic markers for cancer patients receiving immunomodulative therapy

1999 • 27 citations

Phosphoramidon, an endothelin converting enzyme inhibitor attenuates local gastric ischemia-reperfusion injury in rats

1997 • 23 citations

Changes in CD4⁺CD8^–/CD4^–CD8⁺ Ratio and Humoral Immune Functions in Vitamin B₁₂-Deficient Rats

2000 • 19 citations

The effect of 1,25(OH)2 vitamin D3 on subsets of T lymphocytes in postmenopausal women

1997 • 18 citations

BASAL LEVELS OF METALLOTHIONEIN I AND II EXPRESSION IN MOUSE EMBRYO FIBROBLASTS ENHANCE GROWTH IN LOW FOLATE THROUGH A CELL CYCLE MEDIATED PATHWAY

2001 • 18 citations

Inhibition of thymidine synthesis by folate analogues induces a Fas–Fas ligand-independent deletion of superantigen-reactive peripheral T cells

2001 • 18 citations

Vitamin B-12-Deficiency Affects Immunoglobulin Production and Cytokine Levels in Mice

2001 • 16 citations

Low‐Dosage Methotrexate for Treatment and Maintenance of Remission in Patients with Inflammatory Bowel Disease

2002 • 14 citations

Folate Deficiency Delays the Onset But Increases the Incidence of Leukemia in Friend Virus-Infected Mice

1997 • 10 citations

Markedly induced asialoGM1 + CD8 + T cell production and enhancement of antimetastatic activity by interferon β with folic or folinic acid

1997 • 5 citations

Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism

2000 • 5 citations