Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
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References (49)
Aging: A Theory Based on Free Radical and Radiation Chemistry
1956 • 8,252 citations
Mitochondria, Oxidants, and Aging
2005 • 4,115 citations
Premature ageing in mice expressing defective mitochondrial DNA polymerase
2004 • 2,561 citations
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
2003 • 2,209 citations
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
2005 • 2,025 citations
The Biologic Clock: The Mitochondria?
1972 • 1,912 citations
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
1995 • 1,761 citations
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
1988 • 1,709 citations
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1999 • 1,688 citations
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
2005 • 1,670 citations
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
1998 • 1,517 citations
Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster
1994 • 1,461 citations
Oxidant signals and oxidative stress
2003 • 1,378 citations
Age-related changes in oxidized proteins.
1987 • 1,229 citations
Biochemical and molecular investigations in respiratory chain deficiencies
1994 • 1,225 citations
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
2000 • 909 citations
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
1998 • 852 citations
Mitochondrial transcription factor A regulates mtDNA copy number in mammals
2004 • 826 citations
Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain
1993 • 759 citations
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
2003 • 719 citations
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 • 644 citations
The inactivation of Fe-S cluster containing hydro-lyases by superoxide.
1993 • 628 citations
Mitochondrial disease in superoxide dismutase 2 mutant mice
1999 • 581 citations
Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila
2000 • 488 citations
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species
1993 • 484 citations
Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
2000 • 435 citations
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression
1999 • 434 citations
Mitochondria: a practical approach.
1987 • 412 citations
Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.
2002 • 368 citations
The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
1998 • 352 citations
Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts
1992 • 284 citations
Increasedin vivoapoptosis in cells lacking mitochondrial DNA gene expression
2001 • 245 citations
Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?
2004 • 229 citations
Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm
1991 • 203 citations
Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster
2003 • 186 citations
Late-Onset Corticohippocampal Neurodepletion Attributable to Catastrophic Failure of Oxidative Phosphorylation in MILON Mice
2001 • 166 citations
A causal link between respiration and senescence in Podospora anserina
2000 • 164 citations
Isolation of biogenetically competent mitochondria from mammalian tissues and cultured cells
2002 • 157 citations
Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans
2001 • 154 citations
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
2004 • 132 citations
Measurement of ATP production and respiratory chain enzyme activities in mitochondria isolated from small muscle biopsy samples
2002 • 131 citations
No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA
2004 • 86 citations
Mitochondria and ageing
2000 • 66 citations
Establishment of mouse embryo cells in vitro
1977 • 62 citations
Relationship between life expectancy, endogenous antioxidants and products of oxygen free radical reactions in the housefly, Musca domestica
1986 • 52 citations
Age-dependent structural changes in the myocardium of rats. A quantitative light- and electron-microscopic study on the right and left chamber wall
1984 • 51 citations
Antioxidants prolong life span and inhibit the senescence- dependent accumulation of fluorescent pigment (lipofuscin) in clones of Podospora anserina
1978 • 27 citations
CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months
2000 • 16 citations
Methionine-lnduced Alterations in the Life Span, Antioxidant Enzymes, and Peroxide Levels in Aging <i>Zaprionus paravittiger</i> (Diptera)
1995 • 9 citations