Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

On the Origin of Cancer Cells

1956 • 12,141 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

Handbook of methods for oxygen radical research

1987 • 2,395 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Handbook Methods For Oxygen Radical Research

2018 • 762 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

1986 • 247 citations

Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways

1996 • 242 citations

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils.

1996 • 238 citations

Glucose Deprivation-induced Cytotoxicity and Alterations in Mitogen-activated Protein Kinase Activation Are Mediated by Oxidative Stress in Multidrug-resistant Human Breast Carcinoma Cells

1998 • 229 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Analysis of Glutathione, Glutathione Disulfide, Cysteine, Homocysteine, and Other Biological Thiols by High-Performance Liquid Chromatography Following Derivatization by N-(1-Pyrenyl)maleimide

1995 • 218 citations

Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway

1995 • 176 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity

1995 • 135 citations

Cell division in normal and transformed cells: The possible role of superoxide and hydrogen peroxide

1981 • 135 citations

Pregrowth hormone messenger RNA: glucocorticoid induction and identification in rat pituitary cells.

1977 • 131 citations

Escape from redox regulation enhances the transforming activity of Fos.

1993 • 119 citations

Inhibition of angiogenesis.

1992 • 116 citations

Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.

1996 • 110 citations

Nuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent.

1992 • 105 citations

Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.

1994 • 95 citations

Functional Characterization of the Human Basic Fibroblast Growth Factor Gene Promoter

1991 • 93 citations

Angiogenesis and its inhibitors.

1985 • 83 citations

Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death

1997 • 82 citations

Oncogenes and Transcriptional Control

1987 • 82 citations

Sensitivity to chemical oxidants and radiation in CHO cell lines deficient in oxidative pentose cycle activity

1992 • 71 citations

The Role of Glucose in Cellular Defenses Against Cytotoxicity of Hydrogen Peroxide in Chinese Hamster Ovary Cells

1994 • 64 citations

Nuclear signaling induced by ionizing radiation involves colocalization of the activated p56/p53lyn tyrosine kinase with p34cdc2.

1996 • 61 citations

Effect of Ionizing Radiation on AP-1 Binding Activity and Basic Fibroblast Growth Factor Gene Expression in Drug-sensitive Human Breast Carcinoma MCF-7 and Multidrug-resistant MCF-7/ADR Cells

1995 • 60 citations

Pathophysiological mechanismsa of active oxygen

1989 • 53 citations

Basic fibroblast growth factor secreted by an animal tumor is detectable in urine.

1993 • 52 citations

Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts

1995 • 47 citations

Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.

1995 • 46 citations

Hypoglycemia-induced c-Jun Phosphorylation Is Mediated by c-Jun N-terminal Kinase 1 and Lyn Kinase in Drug-resistant Human Breast Carcinoma MCF-7/ADR Cells

1997 • 44 citations

High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide

1996 • 42 citations

Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

1996 • 36 citations

Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells.

1997 • 23 citations

Hypoglycemia-induced AP-1 transcription factor and basic fibroblast growth factor gene expression in multidrug resistant human breast carcinoma MCF-7/ADR cells

1996 • 22 citations

Multinuclear NMR Study of the Metabolism of Drug‐Sensitive and Drug‐Resistant Human Breast Cancer Cells

1987 • 19 citations

Syk and Lyn Are Involved in Radiation-Induced Signaling, but Inactivation of Syk or Lyn Alone Is Not Sufficient to Prevent Radiation-Induced Apoptosis1

1995 • 13 citations

Role of Hydroxyl Radicals in Radiation-Induced Activation of Lyn Tyrosine Kinase in Human B-Cell Precursors

1996 • 10 citations