LIPOPROTEINS AND ATHEROGENESIS

Mortality by cause for eight regions of the world: Global Burden of Disease Study

1997 • 4,053 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin

1986 • 1,857 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1997 • 1,210 citations

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

1991 • 990 citations

Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations.

1992 • 946 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

The Role of Lipids and Lipoproteins in Atherosclerosis

1950 • 808 citations

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

1990 • 767 citations

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels.

1996 • 592 citations

Roles of Infectious Agents in Atherosclerosis and Restenosis

1997 • 566 citations

Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice

1990 • 540 citations

Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators

1997 • 533 citations

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

1992 • 458 citations

Atherosclerotic plaque rupture and thrombosis. Evolving concepts.

1990 • 457 citations

Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein

1993 • 449 citations

Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid

1989 • 448 citations

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

1994 • 415 citations

Angiographic Assessment of Effects of Bezafibrate on Progression of Coronary Artery Disease in Young Male Postinfarction Patients

1996 • 415 citations

Comparison of Statins in Hypertriglyceridemia

1998 • 387 citations

Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II

1993 • 355 citations

Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia.

1994 • 315 citations

Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

1995 • 302 citations

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

1991 • 300 citations

The Coronary Drug Project

1973 • 298 citations

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

1995 • 286 citations

Atherogenesis in transgenic mice expressing human apolipoprotein(a)

1992 • 281 citations

Lipoprotein(a) and Atherosclerosis

1991 • 277 citations

Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene.

1995 • 273 citations

Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillaries

1986 • 273 citations

Levels of lipoprotein Lp(a) decline with neomycin and niacin treatment

1985 • 270 citations

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

1995 • 259 citations

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol

1991 • 259 citations

Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

1995 • 258 citations

Iron, Atherosclerosis, and Ischemic Heart Disease

1999 • 258 citations

Protection Against Atherogenesis in Mice Mediated by Human Apolipoprotein A-IV

1996 • 250 citations

Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.

1996 • 249 citations

Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.

1994 • 248 citations

High Levels of Human Apolipoprotein A-I in Transgenic Mice Result in Increased Plasma Levels of Small High Density Lipoprotein (HDL) Particles Comparable to Human HDL3

1989 • 238 citations

Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

1994 • 235 citations

Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism.

1991 • 234 citations

Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.

1996 • 232 citations

Inhibition of Atherosclerosis Development in Cholesterol-Fed Human Apolipoprotein A-I–Transgenic Rabbits

1996 • 224 citations

Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia

1993 • 217 citations

Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.

1994 • 214 citations

High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase

1997 • 211 citations

Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I.

1992 • 206 citations

Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene

1995 • 199 citations

Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.

1995 • 196 citations

Lipoproteins, Coronary Heart Disease, and Atherosclerosis

1954 • 194 citations

Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice.

1993 • 191 citations

Apolipoprotein J Is Associated with Paraoxonase in Human Plasma

1994 • 186 citations

Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

1996 • 180 citations

Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a).

1992 • 179 citations

Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.

1993 • 173 citations

Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.

1997 • 166 citations

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

1994 • 149 citations

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

1992 • 145 citations

Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice.

1994 • 143 citations

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

1995 • 135 citations

Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice.

1994 • 135 citations

Fluid absorption in isolated perfused colonic crypts.

1995 • 133 citations

Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice.

1993 • 131 citations

Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice

1995 • 128 citations

Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice

1991 • 126 citations

Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.

1993 • 125 citations

Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants

1996 • 124 citations

An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels.

1992 • 122 citations

Familial hypoalphalipoproteinemia in premature coronary artery disease.

1993 • 120 citations

Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice.

1996 • 116 citations

Hepatic Lipase Deficiency Increases Plasma Cholesterol but Reduces Susceptibility to Atherosclerosis in Apolipoprotein E-deficient Mice

1997 • 115 citations

Lecithin:Cholesterol Acyltransferase Overexpression Generates Hyperalpha-lipoproteinemia and a Nonatherogenic Lipoprotein Pattern in Transgenic Rabbits

1996 • 114 citations

Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

1992 • 112 citations

Quantitative Assessment of Aortic Atherosclerosis in APOE*3 Leiden Transgenic Mice and Its Relationship to Serum Cholesterol Exposure

1996 • 110 citations

Targeted Disruption of the Mouse Lecithin:Cholesterol Acyltransferase (LCAT) Gene

1997 • 110 citations

COOH-terminal Disruption of Lipoprotein Lipase in Mice Is Lethal in Homozygotes, but Heterozygotes Have Elevated Triglycerides and Impaired Enzyme Activity

1995 • 109 citations

The Diabetes Atherosclerosis Intervention Study (DAIS): a study conducted in cooperation with the World Health Organization

1996 • 94 citations

Distribution of PAF-acetylhydrolase activity in human plasma low-density lipoprotein subfractions

1994 • 83 citations

Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior.

1994 • 77 citations

Consensus Statement: Role of Therapy With “Statins” in Patients With Hypertriglyceridemia

1998 • 73 citations

Lipid research clinics coronary primary prevention trial: Results and implications

1984 • 70 citations

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

1993 • 70 citations

Overexpression of Human Apolipoprotein B-100 in Transgenic Rabbits Results in Increased Levels of LDL and Decreased Levels of HDL

1995 • 66 citations

Effects of Apoprotein E on Intracellular Metabolism of Model Triglyceride-rich Particles Are Distinct from Effects on Cell Particle Uptake

1995 • 64 citations

Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase

1994 • 60 citations

In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice.

1990 • 60 citations

In the Absence of Endogenous Mouse Apolipoprotein E, Apolipoprotein E*2(Arg-158 → Cys) Transgenic Mice Develop More Severe Hyperlipoproteinemia than Apolipoprotein E*3-Leiden Transgenic Mice

1996 • 51 citations

Indications for low-density lipoprotein apheresis

1994 • 50 citations

Increased response to cholesterol feeding in apolipoprotein C1-deficient mice

1995 • 49 citations

Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).

1994 • 46 citations

Accumulation of human apolipoprotein E in the plasma of transgenic mice.

1990 • 45 citations

Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice.

1996 • 42 citations

Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter. A phenotype associated with increased perinatal mortality and reduced plasma very low density lipoprotein of normal size.

1994 • 41 citations

Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.

1993 • 38 citations

Hypolipidemic and Hyperlipidemic Phenotypes in Transgenic Mice Expressing Human Apolipoprotein E2

1996 • 36 citations

Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).

1994 • 21 citations

Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet-induced hyperbetalipoproteinemia.

1995 • 21 citations

Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promotor in transgenic mice

1991 • 20 citations

The earliest medical texts.

1985 • 17 citations

Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia

1994 • 14 citations

The Earliest Medical Texts

1986 • 12 citations

Transgenic mice expressing full-length human apolipoprotein B-100. Full-length human apolipoprotein B mRNA is essentially not edited in mouse intestine or liver.

1992 • 9 citations

Cardiovascular disease : molecular and cellular mechanisms, prevention, and treatment

1987 • 9 citations

HDL particle measurements: Impact for diagnosis and therapy

1993 • 9 citations

Book Reviews

1989 • 8 citations

The Development and Use of Animal Models in Atherosclerosis Research

1987 • 7 citations

Individual Antigenic Differences of a Human Serum Lipoprotein revealed by a ‘Cold-precipitin’ in the Serum of a Transfused Patient

1965 • 5 citations

[Atherosclerosis and ischemic heart disease. Short historical notes].

1996 • 4 citations

Metabolism of Chylomicron Remnants in Transgenic Mice Expressing Apolipoprotein E in the Intestine

1994 • 3 citations

[Atherosclerosis and ischemic heart disease].

1987 • 2 citations

Deleted Work

1955 • 0 citations