Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

The Theory of Tracer Experiments with ¹³¹I-Labelled Plasma Proteins

1957 • 834 citations

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

1992 • 466 citations

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

1994 • 415 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

Familial apolipoprotein E deficiency.

1986 • 300 citations

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

1993 • 297 citations

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

1995 • 270 citations

Changes in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normo- and hypertriglyceridemic man.

1979 • 264 citations

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

1982 • 260 citations

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

1994 • 211 citations

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1991 • 210 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

1994 • 177 citations

Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects.

1990 • 151 citations

Apolipoprotein E localization in rat hepatocytes by immunogold labeling of cryothin sections

1990 • 150 citations

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 • 142 citations

gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex.

1992 • 141 citations

The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors

1995 • 121 citations

Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG.

1994 • 114 citations

Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans.

1995 • 108 citations

Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats

1990 • 100 citations

Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.

1995 • 94 citations

Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.

1991 • 92 citations

A comparison of the roles of the low density lipoprotein (LDL) receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo

1993 • 78 citations

The LDL-receptor-related protein ??? portrait of a multifunctional receptor

1993 • 78 citations

Effect of the 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat.

1994 • 77 citations

Studies on the etiology of the hyperlipemia in rats fed an atherogenic diet

1980 • 76 citations

Chylomicron-remnant clearance in homozygote and heterozygote Watanabe-heritable-hyperlipidaemic rabbits is defective. Lack of evidence for an independent chylomicron-remnant receptor

1991 • 72 citations

Binding of rat chylomicrons and their remnants to the hepatic low-density-lipoprotein receptor and its role in remnant removal

1988 • 68 citations

Chylomicron remnants: hepatic receptors and metabolism

1995 • 66 citations

A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency

1989 • 65 citations

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.

1994 • 56 citations

Role of low density lipoprotein receptor-dependent and -independent sites in binding and uptake of chylomicron remnants in rat liver.

1988 • 54 citations

Metabolism of apolipoprotein B-100 in large very low density lipoproteins of blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits.

1988 • 51 citations

Chylomicron Metabolism in Normal, Cholesterol-fed, and Watanabe Heritable Hyperlipidemic Rabbits

1995 • 45 citations

Regulation of the hepatic removal of chylomicron remnants and beta-very low density lipoproteins in the rat.

1992 • 42 citations

Novel aspects of vitamin A metabolism in the dog: distribution of lipoprotein retinyl esters in vitamin A-deprived and cholesterol-fed animals

1987 • 34 citations

Binding of low-density lipoprotein and chylomicron remnants to the hepatic low-density lipoprotein receptor of dogs, rats and rabbits demonstrated by ligand blotting. Failure to detect a distinct chylomicron-remnant-binding protein by ligand blotting

1986 • 31 citations

Hyperlipidaemia and atherosclerosis

1989 • 27 citations

A study of the chylomicron metabolism in WHHL rabbits after fat loading. Discrepancy between results based on measurement of apoprotein B-48 or retinyl palmitate

1992 • 20 citations

Retinyl palmitate labeled intestinally derived lipoproteins accumulate in the circulation of WHHL rabbits

1990 • 16 citations