High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats

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1975 • 10,200 citations

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1989 • 6,875 citations

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1986 • 1,257 citations

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1986 • 932 citations

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1996 • 772 citations

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 770 citations

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

1991 • 741 citations

Gender-Linked Brain Injury in Experimental Stroke

1998 • 730 citations

Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.

1996 • 521 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Use of anti-ICAM-1 therapy in ischemic stroke

2001 • 500 citations

Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat).

1994 • 491 citations

Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

1994 • 360 citations

Neuronal Necrosis After Middle Cerebral Artery Occlusion in Wistar Rats Progresses at Different Time Intervals in the Caudoputamen and the Cortex

1995 • 349 citations

Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats.

1994 • 347 citations

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1995 • 346 citations

Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female Rats

2000 • 336 citations

Optimal Depth and Duration of Mild Hypothermia in a Focal Model of Transient Cerebral Ischemia

1998 • 324 citations

Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat

1994 • 319 citations

A Critical Reevaluation of the Intraluminal Thread Model of Focal Cerebral Ischemia

1998 • 287 citations

Contribution of Microglia/Macrophages to Expansion of Infarction and Response of Oligodendrocytes After Focal Cerebral Ischemia in Rats

2000 • 281 citations

The Effect of Hypothermia on Transient Middle Cerebral Artery Occlusion in the Rat

1992 • 276 citations

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Endothelial ICAM-1 Expression Associated With Inflammatory Cell Response in Human Ischemic Stroke

1996 • 264 citations

Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat

1994 • 257 citations

Anti‐CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat

1994 • 231 citations

Mild Hypothermia as a Protective Therapy during Intracranial Aneurysm Surgery: A Randomized Prospective Pilot Trial

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Limitations of tetrazolium salts in delineating infarcted brain

1984 • 193 citations

Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia.

1992 • 187 citations

A Clinical Study of the Parameters and Effects of Temporary Arterial Occlusion in the Management of Intracranial Aneurysms

1994 • 178 citations

Automated Measurement of Infarct Size With Scanned Images of Triphenyltetrazolium Chloride–Stained Rat Brains

1996 • 164 citations

Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion

1997 • 132 citations

Postischemic (1 hour) hypothermia significantly reduces ischemic cell damage in rats subjected to 2 hours of middle cerebral artery occlusion.

1993 • 118 citations

Effects of Delayed Intraischemic and Postischemic Hypothermia on a Focal Model of Transient Cerebral Ischemia in Rats

2000 • 116 citations

A Longitudinal Prospective Study of Soluble Adhesion Molecules in Acute Stroke

1998 • 114 citations

Deliberate Mild Intraoperative Hypothermia for Craniotomy

1994 • 104 citations

Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion

1997 • 102 citations

Postischemic treatment (2–4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat

1995 • 99 citations

Inhibition of Experimental Vasospasm in Rats With the Periadventitial Administration of Ibuprofen Using Controlled-Release Polymers

1999 • 94 citations

Inflammatory reactions at the blood-endothelial interface in acute stroke.

1996 • 89 citations

Effects of Moderate Hypothermia on Leukocyte- Endothelium Interaction in the Rat Pial Microvasculature After Transient Middle Cerebral Artery Occlusion

1999 • 83 citations

Serum levels of intercellular adhesion molecule-1 and E-selectin in patients with acute ischaemic stroke

1997 • 83 citations

Endothelial Cell Expression of Intercellular Adhesion Molecule 1 in Experimental Posthemorrhagic Vasospasm

1997 • 82 citations

Inhibition of leukocyte adhesion: an alternative mechanism of action for anti-inflammatory drugs

1998 • 79 citations

Adhesive glycoproteins CD11a and CD18 are upregulated in the leukocytes from patients with ischemic stroke and transient ischemic attacks

1995 • 62 citations

Inhibition of human polymorphonuclear leukocyte functions by ibuprofen

1987 • 57 citations

PPBP [4-Phenyl-1-(4-phenylbutyl) Piperidine] Decreases Brain Injury After Transient Focal Ischemia in Rats

1996 • 57 citations

Ibuprofen inhibits pyrogen-dependent expression of VCAM-1 and ICAM-1 on human endothelial cells

1996 • 57 citations

Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats

1993 • 56 citations

Principles of Cellular and Molecular Immunology

1994 • 55 citations

Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume.

1993 • 53 citations

Mouse and large-animal toxicology studies of twelve antitumor agents: Relevance to starting dose for Phase I clinical trials

1979 • 47 citations

Increased expression of adhesion molecule CD18 (LFA-1β) on the leukocytes of peripheral blood in patients with acute ischemic stroke

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Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs.

1987 • 32 citations

Reversible middle cerebral artery occlusion in rats using an intraluminal thread technique

1994 • 29 citations

Principles of aneurysm surgery: cerebral ischemic protection, hypothermia, and circulatory arrest.

1994 • 22 citations

Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs.

1987 • 11 citations

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1977 • 10 citations

Principles of cellular and molecular immunology

1994 • 8 citations