Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1982 • 3,566 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

The Harvard Cooperative Stroke Registry

1978 • 1,180 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 • 898 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Leukocyte-endothelial interactions

1985 • 834 citations

Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury

1988 • 794 citations

Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats.

1993 • 706 citations

Leukocyte-endothelial interactions

1985 • 635 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion.

1994 • 485 citations

P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion.

1994 • 428 citations

Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification

1991 • 382 citations

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons.

1992 • 368 citations

Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats.

1994 • 347 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

1988 • 333 citations

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide

1992 • 302 citations

Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion.

1992 • 296 citations

Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells

1990 • 293 citations

Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA‐1 subunit‐specific monoclonal antibodies

1991 • 233 citations

The role of the neutrophil and free radicals in ischemic myocardial injury

1989 • 214 citations

Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment.

1991 • 206 citations

Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.

1990 • 205 citations

Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells

1992 • 204 citations

Monoclonal Antibody to the ICAM-1 Adhesion Site Reduces Neurological Damage in a Rabbit Cerebral Embolism Stroke Model

1993 • 202 citations

Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1

1993 • 189 citations

Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia.

1992 • 187 citations

Relative contribution of the leukocyte molecules MO1, LFA‐1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue‐ and stimulus‐specific

1988 • 162 citations

Convulsants induce interleukin-1β messenger RNA in rat brain

1990 • 158 citations

Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules.

1993 • 155 citations

Delayed Hypoperfusion after Incomplete Forebrain Ischemia in the Rat. The Role of Polymorphonuclear Leukocytes

1989 • 144 citations

Nafazatrom-induced salvage of ischemic myocardium in anesthetized dogs is mediated through inhibition of neutrophil function.

1985 • 137 citations

Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha.

1989 • 135 citations

Neutrophil as a mediator of ischemic edema formation in the brain

1991 • 131 citations

Adhesion-related molecules in the central nervous system. Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis.

1991 • 128 citations

Migration of neutrophils across monolayers of cultured microvascular endothelial cells An in vitro model of leucocyte extravasation

1987 • 121 citations

Expression of leucocyte adhesion molecules at the human blood‐brain barrier (BBB)

1992 • 109 citations

Role of beta 2 integrins and ICAM-1 in lung injury following ischemia-reperfusion of rat hind limbs.

1993 • 107 citations

Role of ICAM-1 in neutrophil-mediated lung vascular injury after occlusion and reperfusion

1991 • 106 citations

Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4.

1992 • 81 citations

Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adherence.

1992 • 76 citations

Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-d-aspartate neurotoxicity

1993 • 73 citations

Molecular mechanisms underlying lymphocyte recirculation II. Differential regulation of LFA‐1 in the interaction between lymphocytes and high endothelial cells

1991 • 57 citations

Induction of ICAM-1 on human neural cells and mechanisms of neutrophil-mediated injury.

1991 • 44 citations

Effect of a novel thromboxane A2 receptor antagonist, S-1452, on postischemic brain injury in rats.

1993 • 22 citations