Inhibition of leukocyte adhesion: an alternative mechanism of action for anti-inflammatory drugs

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

1995 • 985 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Nonsteroidal Antiinflammatory Drugs — Differences and Similarities

1991 • 756 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils.

1995 • 346 citations

The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase.

1995 • 310 citations

Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.

1996 • 308 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

Mechanisms involved in Helicobacter pylori—Induced inflammation

1993 • 270 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.

1995 • 163 citations

Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats

1995 • 105 citations

L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro.

1997 • 92 citations

Molecular determinants of aspirin-induced neutrophil adherence to endothelial cells

1993 • 80 citations

Regulation of integrin function

1996 • 78 citations

Secreted glucocorticoids regulate leukocyte-endothelial interactions in inflammation. A direct vital microscopic study

1995 • 76 citations

Prevention of cytokine‐induced changes in leukocyte adhesion receptors by nonsteroidal antiinflammatory drugs from the oxicam family

1997 • 69 citations

Probucol Downregulates E-Selectin Expression on Cultured Human Vascular Endothelial Cells

1996 • 41 citations

Diclofenacinhibits endothelial cell adhesion molecule expression induced with lipopolysaccharide

1996 • 38 citations

Actions and toxicity of nonsteroidal anti-inflammatory drugs

1996 • 35 citations

Inhibition of neutrophil function by aspirin-like drugs (NSAIDS): Requirement for assembly of heterotrimeric G proteins in bilayer phospholipid

1994 • 35 citations

Aceclofenac, a new nonsteroidal antiinflammatory drug, decreases the expression and function of some adhesion molecules on human neutrophils.

1996 • 33 citations

Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression

1996 • 31 citations

NSAIDs upregulate β₂‐integrin expression on human neutrophils through a calcium‐dependent pathway

1997 • 28 citations

Salsalate, a nonacetylated salicylate, is as efficacious as diclofenac in patients with rheumatoid arthritis. Salsalate-Diclofenac Study Group.

1995 • 28 citations

Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1.

1996 • 21 citations

Gold sodium thiomalate down-regulates intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells.

1994 • 14 citations

EFFECTS OF VENOUS HÆMORRHAGE AND INTRAVENOUS INFUSION IN DOGS

1900 • 10 citations

Anti-integrin drugs developed to treat inflammation

1996 • 9 citations