Clinical Pharmacokinetic Properties of the Macrolide Antibiotics

Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms

1987 • 459 citations

Antibiotic entry into human polymorphonuclear leukocytes

1982 • 313 citations

A Guide to Use of Antibiotics in Patients with Renal Disease

1967 • 205 citations

Inhibition of theophylline clearance by troleandomycin

1977 • 170 citations

Transplacental Passage of Erythromycin and Clindamycin

1973 • 169 citations

Pharmacokinetics of Tissue Penetration of Antibiotics

1981 • 153 citations

Roxithromycin

1989 • 140 citations

Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells

1987 • 128 citations

Inhibition of methylprednisolone elimination in the presence of clarithromycin therapy

1999 • 127 citations

The effect of troleandomycin on methylprednisolone elimination

1980 • 122 citations

Dual effects of macrolide antibiotics on rat liver cytochrome P-450

1983 • 116 citations

Intersubject and dose‐related variability after intravenous administration of erythromycin.

1980 • 112 citations

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans

1983 • 104 citations

Drug interactions and hepatitis produced by some macrolide antibiotics

1985 • 99 citations

Roxithromycin: a pharmacokinetic review of a macrolide

1987 • 98 citations

Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450

1981 • 98 citations

Erythromycin: A Microbial and Clinical Perspective After 30 Years of Clinical Use (Second of Two Parts)

1985 • 97 citations

Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim, and metronidazole into human polymorphonuclear leukocytes

1987 • 90 citations

Effect of erythromycin on carbamazepine kinetics

1983 • 86 citations

Fluorimetric determination of erythromycin and erythromycin ethylsuccinate in serum by a high-performance liquid chromatographic post-column, on-stream derivatization and extraction method

1978 • 83 citations

Effect of erythromycin on theophylline kinetics

1981 • 83 citations

Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats

1983 • 80 citations

MEASUREMENT OF PULMONARY ERYTHROMYCIN CONCENTRATION IN PATIENTS WITH LOBAR PNEUMONIA BY MEANS OF POSITRON TOMOGRAPHY

1982 • 78 citations

Effects of three antibiotics on theophylline kinetics

1979 • 75 citations

The influence of food on the absorption of antimicrobial agents

1982 • 75 citations

In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria

1984 • 74 citations

In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs

1983 • 73 citations

Determination of Erythromycin in Serum and Urine by High-Performance Liquid Chromatography with Ultraviolet Detection

1985 • 62 citations

Erythromycin Uptake and Accumulation by Human Polymorphonuclear Leukocytes and Efficacy of Erythromycin in Killing Ingested Legionella pneumophila

1984 • 62 citations

Comparative pharmacokinetics of macrolides

1987 • 61 citations

Does Serum Protein Binding Inhibit Tissue Penetration of Antibiotics?

1987 • 59 citations

Carbamazepine Intoxication Due to Triacetyloleandomycin Administration in Epileptic Patients

1980 • 58 citations

Cyclosporin-erythromycin interaction in normal subjects.

1987 • 58 citations

Interspecies Correlation of the Pharmacokinetics of Erythromycin, Oleandomycin, and Tylosin

1985 • 57 citations

Uptake, accumulation, and egress of erythromycin by tissue culture cells of human origin

1985 • 57 citations

Analysis of erythromycin in biological fluids by high-performance liquid chromatography with electrochemical detection

1983 • 57 citations

Serum Protein Binding of Erythromycin, Lincomycin, and Clindamycin

1973 • 53 citations

Antibiotic uptake by alveolar macrophages of smokers

1985 • 52 citations

The Effect of Erythromycin on the Disposition Kinetics of Warfarin

1984 • 51 citations

Pulmonary disposition of roxithromycin (RU 28965), a new macrolide antibiotic

1987 • 48 citations

Erythromycin concentrations in middle ear exudates.

1971 • 45 citations

A study of the interaction of roxithromycin with theophylline and carbarmazepine

1987 • 44 citations

Excretion of erythromycin and its enhanced activity in urine against gram-negative bacilli with alkalinization.

1968 • 43 citations

Possible Warfarin-Erythromycin Interaction

1980 • 42 citations

Erythromycin

1987 • 42 citations

Factors influencing the assay of antimicrobial drugs in clinical samples by the agar plate diffusion method

1982 • 42 citations

Rosamicin—a New Drug for the Treatment of Bacterial Prostatitis

1977 • 40 citations

Levels of erythromycin in pulmonary tissue and bronchial mucus compared to those of amoxycillin

1981 • 39 citations

Antibiotic action on phagocytosed bacteria measured by a new method for determining viable bacteria

1984 • 38 citations

Tissue distribution of roxithromycin

1987 • 38 citations

In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis

1987 • 38 citations

The interaction of erythromycin with theophylline

1987 • 38 citations

Pharmacokinetic interaction between theophylline and erythromycin.

1982 • 37 citations

Fluorometric determination of erythromycin and erythromycin propionate in whole blood or plasma and correlation of results with microbiological assay

1976 • 37 citations

Selection of an oral erythromycin product

1980 • 36 citations

The Effects of Erythromycin on Theophylline Elimination in Normal Males

1982 • 35 citations

Comparative Pharmacology of Josamycin and Erythromycin Stearate

1976 • 35 citations

Pharmacokinetics of erythromycin ethylsuccinate and estolate in infants under 4 months of age

1981 • 34 citations

Pharmacokinetics of macrolides, lincosamides and streptogramins

1985 • 34 citations

Pharmacokinetics of Erythromycin in Man1

2015 • 34 citations

Biliary excretion of erythromycin after parenteral administration.

1979 • 32 citations

Intraphagocytic penetration of macrolides: in-vivo comparison of erythromycin and spiramycin

1985 • 31 citations

Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base

1979 • 31 citations

Pharmacokinetics of single-dose erythromycin in normal and alcoholic liver disease subjects

1982 • 31 citations

Erythromycin

1982 • 31 citations

Penetration of Erythromycin Stearate into Maxillary Sinus Mucosa and Secretion in Chronic Maxillary Sinusitis

1977 • 30 citations

Pharmacokinetic drug interactions with macrolide antibiotics

1985 • 30 citations

Kinetics of erythromycin uptake and release by human lymphocytes and polymorphonuclear leucocytes

1986 • 30 citations

Absorption of erythromycin.

1953 • 28 citations

The influence of food on the bioavailability of new formulations of erythromycin stearate and base.

1979 • 28 citations

The Effect of Erythromycin on Theophylline Pharmacokinetics at Steady State

1982 • 28 citations

SPIRAMYCIN IN THE PREVENTION OF POSTOPERATIVE STAPHYLOCOCCAL INFECTION

1968 • 28 citations

Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin

1986 • 28 citations

Interaction between cyclosporin and erythromycin in a kidney transplant patient

1986 • 27 citations

Pharmacokinetics and tissue penetration of roxithromycin after multiple dosing

1987 • 27 citations

Evaluation of Spiramycin as a Therapeutic Agent for Elimination of Nasopharyngeal Pathogens: Possible Use of Spiramycin for Middle Ear Infections and for Gonococcal and Meningococcal Nasopharyngeal Carriage

1978 • 26 citations

Automated high-performance liquid chromatographic determination of spiramycin by direct injection of plasma, using column-switching for sample clean-up

1985 • 25 citations

Pharmacokinetics of Erythromycin in Normal and Alcoholic Liver Disease Subjects

1982 • 25 citations

Factors affecting the absorption and biliary excretion of erythromycin and two of its derivatives in humans

1961 • 25 citations

Spiramycin

1956 • 25 citations

Influence of study design in assessing food effects on absorption of erythromycin base and erythromycin stearate

1981 • 24 citations

In vitro and in vivo antibacterial activity of 9,3"-di-O-acetyl midecamycin (Mom), a new macrolide antibiotic.

1981 • 24 citations

Concentration of Antibiotic and Chemotherapeutic Agents in the Ejaculum

1968 • 24 citations

Penetration of Erythromycin Through Respiratory Mucosa: A Study Using Secretory Otitis Media as a Model

1979 • 24 citations

Studies on Absorption of a Newly Developed Enteric‐Coated Erythromycin Base

1977 • 23 citations

Effects of josamycin on carbamazepine kinetics

1987 • 22 citations

[Delay in elimination of theophylline due to troleandomycin. No effect of josamycin (author's transl)].

1980 • 22 citations

Influence of food on absorption of erythromycin ethyl succinate

1980 • 22 citations

Bioavailability of Erythromycin Ethylsuccinate in Pediatric Patients

1978 • 21 citations

Antimicrobial chemotherapy of chlamydial infection: Where next?

1986 • 21 citations

Depression of theophylline metabolism and elimination by troleandomycin and erythromycin

1981 • 20 citations

The distribution volume of some antibiotics.

1957 • 20 citations

In-vitro activity of RU 28965, a new macrolide, compared to that of erythromycin

1986 • 19 citations

Erythromycin binding to human serum

1982 • 19 citations

The biliary excretion of erythromycin (ilotycin).

1956 • 17 citations

[Influence of a new macrolide, midecamycin on theophylline pharmacokinetics (author's transl)].

1981 • 17 citations

Bioinequivalence of Erythromycin Ethylsuccinate and Enteric‐Coated Erythromycin Pellets Following Multiple Oral Doses

1985 • 17 citations

Single‐ and Multiple‐Dose Bioequivalence of Erythromycin Pharmaceutical Alternatives

1980 • 16 citations

Determination of josamycin in plasma, erythrocytes and leucocytes via high-performance liquid chromatography by direct injection of plasma or homogenized blood cells, using alternating sample clean-up columns

1985 • 16 citations

Pharmacokinetics of roxitharomycin in paediatrics

1987 • 15 citations

Pharmacokinetics of roxithromycin in renal and hepatic failure and drug interactions

1987 • 15 citations

The Excretion of Rosaramicin in Breast Milk

1985 • 14 citations

Factors affecting the in-vitro activity of roxithromycin

1987 • 14 citations

Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses.

1985 • 14 citations

High-pressure liquid chromatographic method for determination of rosaramicin in humans

1980 • 13 citations

The excretory products of N-methyl-C14-erythromycin in rats.

1956 • 13 citations

Penetration of erythromycin into tonsillar tissue

1985 • 12 citations

Pharmacokinetics of a New, Microencapsulated Erythromycin Base after Repeated Oral Doses

1982 • 12 citations

[A minor case of ergotism appearing to be connected with a potentialisation of ergotamine tartrate by erythromycine ethyl-succinate (author's transl)].

1979 • 12 citations

Studies on Absorption, Distribution, Metabolism and Excretion of a New Macrolide Antibiotic SF-837. I. Absorption, Metabolism and Excretion of SF-837

1973 • 12 citations

[RU 28965, a new semi-synthetic macrolide. Bioavailability and pharmacokinetic profile after oral administration].

1985 • 11 citations

The pharmacokinetics and tolerance of oral erythromycin stearate compared with erythromycin ethylsuccinate: implications for preventing endocarditis

1984 • 11 citations

Pharmacokinetics of erythromycin in patients with different degrees of renal impairment.

1986 • 11 citations

Penetration of erythromycin into human peripheral lymph

1982 • 11 citations

Josamycin and Rosamicin: In Vitro Comparisons with Erythromycin and Clindamycin

1976 • 11 citations

[Influence of josamycine treatment on carbamazepine kinetics (author's transl)].

1982 • 11 citations

Erythromycin: clinical review I. Clinical pharmacology.

1977 • 10 citations

Effect of concomitant food intake on absorption kinetics of erythromycin in healthy volunteers

1985 • 10 citations

Comparative Bioavailability Evaluation of Erythromycin Base and Its Salts and Esters. I. Erythromycin Estolate Capsules Versus Enteric‐Coated Erythromycin Base Tablets

1980 • 10 citations

Pharmacokinetics and metabolism of rosaramicin in humans

1984 • 10 citations

[Spiramycin ; therapeutic value in humans. (author's transl)].

1982 • 9 citations

Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man

1979 • 9 citations

The pharmacokinetics of two erythromycin esters in plasma and in saliva following oral administration in humans.

1981 • 9 citations

Elevated serum theophylline concentration following cessation of erythromycin treatment.

1986 • 9 citations

Effects of Phenobarbitone on the Distribution, Metabolism and Biliary Excretion of Erythromycin in Rats

1980 • 8 citations

Antibiotics excretion in canine vaginal and urethral secretions.

1978 • 8 citations

In vitro studies on spiramycin; activity, resistance, antibiogram, humoral concentrations.

1955 • 8 citations

Influence of Food and Hepatobiliary Disease on the Excretion of Josamycin

1972 • 7 citations

Isolation and identification of a metabolite of rosaramicin in human urine.

1984 • 7 citations

Erythromycin.

1970 • 7 citations

[Theophylline and antibiotics. Absence of interaction with josamycin].

1984 • 6 citations

The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate.

1987 • 5 citations

[Drug interactions with macrolids compared action of two macrolids on liver microsomal activity ].

1982 • 5 citations

Tissue penetration of erythromycin in Waldeyer's ring and bacteriology of secretory otitis media.

1981 • 5 citations

Influence of theophylline on the renal clearance of erythromycin.

1987 • 5 citations

[Pharmacokinetic study of antibiotics in human respiratory tract (author's transl)].

1978 • 5 citations

Pharmacokinetics and metabolism of [14C]rosaramicin in dogs

1986 • 5 citations

Erythromycin ethyl succinate: Diffusion through interstitial dermal fluid

1987 • 4 citations

Erythromycin lactobionate: pharmacokinetics and uterine tissue levels

1987 • 4 citations

[Therapeutic activity and pharmacokinetic behavior of miokamycin in the respiratory system].

1984 • 3 citations

[Effect of spiramycin on the pathogenicity and growth of gram positive bacteria].

1972 • 3 citations

Penetration Of Erythromycin In Respiratory Tract Infections

1984 • 3 citations

Josamycin chemical determination in biological fluids.

1982 • 2 citations

[Pharmacokinetics of josamycin in man and distribution in various compartments].

1982 • 1 citations

[Microbiologic determination of tonsil and ocular levels of josamycin in hospitalized patients].

1982 • 1 citations

[Diffusibility of 2 macrolide antibiotics into human extravascular fluids].

1982 • 1 citations

[Prostatic tissue levels of josamycin].

1982 • 1 citations

[Concentration of macrolide antibiotics in various masticatory tissues (VII)].

1984 • 1 citations

[Use of erythromycin suppositories in pediatric practice].

1973 • 1 citations