New directions for macrolide antibiotics: structural modifications and in vitro activity

Prenatal Management of 746 Pregnancies at Risk for Congenital Toxoplasmosis

1988 • 491 citations

Macrolide antibiotics. Chemistry, biology, and practice

1985 • 482 citations

Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms

1987 • 459 citations

Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides

1988 • 310 citations

Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-aza-9a-homoerythromycin A derivatives; A new class of macrolide antibiotics, the azalides.

1988 • 238 citations

Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A.

1984 • 229 citations

Acid degradation of erythromycin A and erythromycin B

1971 • 198 citations

Erythromycin: A Microbial and Clinical Perspective After 30 Years of Clinical Use (First of Two Parts)

1985 • 195 citations

Macrolides with gastrointestinal motor stimulating activity

1987 • 176 citations

In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide

1986 • 164 citations

Susceptibility of Campylobacter pylori to macrolides and fluoroquinolones

1988 • 124 citations

Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii

1988 • 121 citations

Erythromycin: A Microbial and Clinical Perspective After 30 Years of Clinical Use (Second of Two Parts)

1985 • 97 citations

Modification of macrolide antibiotics. Synthesis of 11-deoxy-11-(carboxyamino)-6-O-methylerythromycin A 11,12-(cyclic esters) via an intramolecular Michael reaction of O-carbamates with an .alpha.,.beta.-unsaturated ketone

1988 • 94 citations

Antibacterial activity of roxithromycin: A laboratory evaluation.

1986 • 87 citations

In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondii

1988 • 86 citations

New macrolides active against Streptococcus pyogenes with inducible or constitutive type of macrolide-lincosamide-streptogramin B resistance

1989 • 85 citations

In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria

1984 • 74 citations

In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs

1983 • 73 citations

Macrolide Resistance in Staphylococcus aureus : Inducers of Macrolide Resistance

1977 • 72 citations

In vitro and in vivo activities of macrolides against Mycobacterium leprae

1988 • 66 citations

Activities of amikacin, roxithromycin, and azithromycin alone or in combination with tumor necrosis factor against Mycobacterium avium complex

1988 • 62 citations

Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q).

1981 • 60 citations

Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: Synthesis and structure-activity relationship of its acyl derivatives.

1987 • 55 citations

In vitro comparison of the activity of doxycycline, tetracycline, erythromycin and a new macrolide, CP 62993, against Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum.

1988 • 52 citations

Antibacterial Activity of 2′-Esters of Erythromycin

1969 • 51 citations

In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii

1987 • 47 citations

In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin, and clindamycin

1987 • 46 citations

Antibacterial activity of 9(S)-erythromycylamine-aldehyde condensation products

1974 • 46 citations

Activity of roxithromycin (RU 28965), a macrolide, against Toxoplasma gondii infection in mice

1986 • 45 citations

Activity of A-56268 compared with that of erythromycin and other oral agents against aerobic and anaerobic bacteria

1987 • 43 citations

New fluorinated erythromycins obtained by mutasynthesis.

1983 • 43 citations

Susceptibility of bite wound bacteria to seven oral antimicrobial agents, including RU-985, a new erythromycin: considerations in choosing empiric therapy

1986 • 42 citations

Acyl derivatives of 16-membered macrolides. II. Antibacterial activities and serum levels of 3"-O-acyl derivatives of leucomycin.

1981 • 41 citations

In vitro activity of Ro 15-8074, Ro 19-5247, A-56268, and roxithromycin (RU 28965) against Neisseria gonorrhoeae and Chlamydia trachomatis

1987 • 39 citations

The in-vitro activity of CP-62,993 against Haemophilus influenzae, Branhamella catarrhalis, staphylococci and streptococci

1988 • 38 citations

In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis

1987 • 38 citations

Antibacterial Activity of 2′-Esters of Erythromycin

1969 • 38 citations

Activity of A-56268 (TE-031), a new macrolide, against Toxoplasma gondii in mice

1988 • 35 citations

In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms

1987 • 31 citations

In vitro activities of U-63366, a spectinomycin analog; roxithromycin (RU 28965), a new macrolide antibiotic; and five quinolone derivatives against Haemophilus ducreyi

1986 • 30 citations

In vitro activity of A-56268 (TE-031) and four other antimicrobial agents against Chlamydia trachomatis

1987 • 29 citations

Molecular structure of 9-deoxy-11-deoxy-9-11-(imino(2-(2-methoxyethoxy)ethylidene)oxy)-(9S)-erythromycin, a new erythromycin derivative

1979 • 28 citations

Antimicrobial susceptibilities of southern African isolates of Haemophilus ducreyi

1988 • 28 citations

Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin

1986 • 28 citations

In vitro activity of A-56268 (TE-031), a new macrolide antibiotic, compared with that of erythromycin and other antimicrobial agents

1987 • 27 citations

The choice of antimicrobial drugs.

1988 • 26 citations

In vitro and in vivo antibacterial activity of 9,3"-di-O-acetyl midecamycin (Mom), a new macrolide antibiotic.

1981 • 24 citations

Susceptibility testing of macrolide antibiotics against Haemophilus influenzae and correlation of in vitro results with in vivo efficacy in a mouse septicemia model

1987 • 24 citations

Susceptibility of Campylobacter jejuni and Campylobacter coli to macrolides and related compounds

1985 • 23 citations

Comparative in-vitro activity of A-56268 (TE-031), a new macrolide antibiotic

1987 • 23 citations

Chemical modification of spiramycins. IV. Synthesis and in vitro and in vivo activities of 3", 4"-diacylates and 3, 3" ,4"-triacylates of spiramycin I.

1984 • 23 citations

Variability of clarithromycin and erythromycin susceptibility tests with Haemophilus influenzae in four different broth media and correlation with the standard disk diffusion test

1988 • 21 citations

The structure of erythromycin A cyclic carbonate

1975 • 20 citations

Activity of macrolides against organisms responsible for respiratory infection with emphasis on Mycoplasma and Legionella

1987 • 19 citations

In vitro activity of the new macrolide antibiotic roxithromycin (RU 28965) against clinical isolates of Haemophilus influenzae

1986 • 17 citations

The clinical use of macrolides

1988 • 16 citations

ChemInform Abstract: CHEMICAL MODIFICATION AND STRUCTURE‐ACTIVITY RELATIONSHIP OF MACROLIDES

1985 • 16 citations

Aglycon modifications of erythromycin A: regiospecific and stereospecific elaboration of the C-12 position

1987 • 14 citations

Erythromycin A 11,12-methylene acetal.

1988 • 14 citations

Effects of rokitamycin and other macrolide antibiotics on Mycoplasma pneumoniae in L cells

1987 • 13 citations

In vitro Susceptibility of <i>Mycobacterium avium </i>to a New Macrolide (RU-28965)

1987 • 13 citations

Bacteriological evaluation of midecamycin acetate and its metabolites.

1982 • 11 citations

Comparative in-vitro activities of A-56268 (TE-031) and erythromycin against 306 clinical isolates

1988 • 10 citations

In vitro activity of flurithromycin, a novel macrolide antibiotic.

1986 • 10 citations

Comparative antimicrobial activity of the new macrolide flurithromycin against respiratory pathogens

1988 • 10 citations

RV11 (Propionyl Erythromycin Mercaptosuccinate) Pharmacokinetics in Bronchial Secretions

1986 • 9 citations

Molecular structure of 9-deoxy-11-deoxy-9-11-[imino(2-(2-methoxy)ethylidene)oxy]-(9S)-erythromycin, a new erythromycin derivative.

1979 • 8 citations

In-vitro evaluation of miokamycin: bactericidal activity against streptococci

1984 • 8 citations

The activity of miokamycin (MOM) against Chlamydia trachomatis and mycoplasmas in vitro

1983 • 8 citations

Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis

1988 • 7 citations

The evolving role of erythromycin in medicine.

1986 • 5 citations

Human pharmacokinetics of erythromycin propionate-N-acetylcysteinate: comparative evaluation with erythromycin stearate and N-acetylcysteine.

1988 • 1 citations