Dark adaptation in vertebrate photoreceptors

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Molecular Basis of Visual Excitation

1968 • 1,002 citations

Responses of retinal rods to single photons.

1979 • 971 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis.

1984 • 689 citations

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

1988 • 634 citations

Saturation of the Rod Mechanism of the Retina at High Levels of Stimulation

1954 • 580 citations

The retinal pigment epithelium: a versatile partner in vision

1993 • 577 citations

Changes in time scale and sensitivity in turtle photoreceptors

1974 • 539 citations

Pre-Lumirhodopsin and the Bleaching of Visual Pigments

1963 • 520 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Two components of electrical dark noise in toad retinal rod outer segments.

1980 • 462 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin

1993 • 401 citations

Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin

1993 • 401 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Calcium and light adaptation in retinal rods and cones

1988 • 387 citations

Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

1985 • 381 citations

Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradients

1989 • 374 citations

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1994 • 373 citations

The Ferrier Lecture, 1962 Visual adaptation

1965 • 358 citations

Photoreceptor light adaptation is mediated by cytoplasmic calcium concentration

1988 • 349 citations

Electrogenic Na–Ca exchange in retinal rod outer segment

1984 • 346 citations

The calcium feedback signal in the phototransduction cascade of vertebrate rods

1994 • 290 citations

THE INFLUENCE OF LIGHT ADAPTATION ON SUBSEQUENT DARK ADAPTATION OF THE EYE

1937 • 274 citations

The ionic selectivity and calcium dependence of the light‐sensitive pathway in toad rods.

1985 • 269 citations

Sensitivity of toad rods: Dependence on wave‐length and background illumination.

1976 • 264 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors

1990 • 258 citations

Calcium-dependent regulation of cyclic GMP phosphodiesterase by a protein from frog retinal rods

1991 • 242 citations

Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors.

1989 • 241 citations

Regulation of sensitivity in vertebrate rod photoreceptors by calcium

1996 • 237 citations

Light-dependent delay in the falling phase of the retinal rod photoresponse

1992 • 232 citations

The role of arrestin and retinoids in the regeneration pathway of rhodopsin.

1992 • 217 citations

Bleached pigment activates transduction in isolated rods of the salamander retina.

1994 • 213 citations

Control of light‐sensitive current in salamander rods.

1988 • 207 citations

Calcium homeostasis in the outer segments of retinal rods from the tiger salamander.

1992 • 186 citations

Visual transduction in vertebrate rods and cones: A tale of two transmitters, calcium and cyclic GMP

1986 • 178 citations

Na+-Ca2+ exchange in bovine rod outer segments requires and transports K+

1989 • 172 citations

Cytoplasmic calcium as the messenger for light adaptation in salamander rods.

1989 • 162 citations

Measurement of the intracellular free calcium concentration in salamander rods

1986 • 153 citations

Calcium controls light-triggered formation of catalytically active rhodopsin

1994 • 153 citations

Measurement of the scotopic pigment in the living human eye

1955 • 150 citations

The involvement of rod photoreceptors in dark adaptation

1981 • 141 citations

Ca2+ modulation of the cGMP‐gated channel of bullfrog retinal rod photoreceptors.

1995 • 131 citations

Light adaptation in cone photoreceptors of the salamander: a role for cytoplasmic calcium.

1990 • 129 citations

Calcium and the mechanism of light adaptation in vertebrate photoreceptors

1990 • 112 citations

The cGMP-phosphodiesterase and its contribution to sensitivity regulation in retinal rods

1995 • 110 citations

Free calcium concentrations in bullfrog rods determined in the presence of multiple forms of Fura-2

1994 • 106 citations

Intracellular biochemical manipulation of phototransduction in detached rod outer segments.

1987 • 105 citations

Cellular mechanisms that underlie bleaching and background adaptation.

1990 • 103 citations

Characterization of guanylate cyclase activity in single retinal rod outer segments

1995 • 99 citations

Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones

1993 • 97 citations

Transducin Activation by the Bovine Opsin Apoprotein

1995 • 92 citations

Dark adaptation of toad rod photoreceptors following small bleaches

1994 • 91 citations

Effects of lowered cytoplasmic calcium concentration and light on the responses of salamander rod photoreceptors.

1995 • 82 citations

Sensitization of bleached rod photoreceptors by 11-cis-locked analogues of retinal.

1990 • 80 citations

The kinetics of inactivation of the rod phototransduction cascade with constant Ca2+i.

1996 • 72 citations

Support for the equivalent light hypothesis for RP

1995 • 71 citations

Bleached pigment activates transduction in salamander cones.

1995 • 71 citations

Spontaneous quantal events induced in toad rods by pigment bleaching

1980 • 68 citations

Visual pigment bleaching in isolated salamander retinal cones. Microspectrophotometry and light adaptation.

1993 • 68 citations

Regulation of cellular signal transduction pathways by desensitization and amplification

1994 • 62 citations

Chapter 9 Enzymes and proteins of the mammalian visual cycle

1990 • 39 citations

Light adaptation and the rising phase of the flash photocurrent of salamander retinal rods.

1995 • 39 citations

Static and dynamic actions of cytoplasmic Ca2+ in the adaptation of responses to saturating flashes in salamander rods.

1996 • 37 citations

Incorporation of analogues of GTP and GDP into rod photoreceptors isolated from the tiger salamander.

1988 • 30 citations

Termination of photoreceptor responses

1994 • 23 citations

Role of cytoplasmic calcium concentration in the bleaching adaptation of salamander cone photoreceptors.

1996 • 15 citations

Future directions for rhodopsin structure and function studies

1995 • 7 citations