Transducin Activation by the Bovine Opsin Apoprotein

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

Chemistry of Visual Adaptation in the Rat

1960 • 542 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

Nature of the primary photochemical events in rhodopsin and bacteriorhodopsin

1990 • 446 citations

THE MOLAR EXTINCTION OF RHODOPSIN

1953 • 444 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

1992 • 439 citations

Three cytoplasmic loops of rhodopsin interact with transducin.

1989 • 370 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

THE ACTION OF LIGHT ON RHODOPSIN

1958 • 296 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1991 • 273 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors.

1989 • 241 citations

Constitutive activation of opsin: Influence of charge at position 134 and size at position 296

1993 • 218 citations

The role of arrestin and retinoids in the regeneration pathway of rhodopsin.

1992 • 217 citations

Millisecond activation of transducin in the cyclic nucleotide cascade of vision

1984 • 211 citations

Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296

1992 • 169 citations

Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group

1993 • 166 citations

Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state.

1993 • 148 citations

Light-Induced Interaction between Rhodopsin and the GTP-Binding Protein. Metarhodopsin II Is the Major Photoproduct Involved

1982 • 142 citations

The transitory complex between photoexcited rhodopsin and transducin

1989 • 129 citations

Visual pigment and photoreceptor sensitivity in the isolated skate retina.

1978 • 124 citations

Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II

1992 • 111 citations

Deprotonation of the Schiff base of rhodopsin is obligate in the activation of the G protein.

1986 • 108 citations

Dark-adaptation: A new hypothesis

1964 • 106 citations

Allosteric behavior in transducin activation mediated by rhodopsin. Initial rate analysis of guanine nucleotide exchange.

1987 • 105 citations

Cellular mechanisms that underlie bleaching and background adaptation.

1990 • 103 citations

Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones

1993 • 97 citations

Subsecond deactivation of transducin by endogenous GTP hydrolysis

1990 • 95 citations

Functional equivalence of metarhodopsin II and the Gt-activating form of photolyzed bovine rhodopsin

1991 • 92 citations

Light-stable rhodopsin. I. A rhodopsin analog reconstituted with a nonisomerizable 11-cis retinal derivative.

1992 • 91 citations

Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids

1985 • 82 citations

Sensitization of bleached rod photoreceptors by 11-cis-locked analogues of retinal.

1990 • 80 citations

Rhodopsin photoproducts and rod sensitivity in the skate retina.

1977 • 77 citations

Differential scanning calorimetry of bovine rhodopsin in rod‐outer‐segment disk membranes

1991 • 75 citations

Sites of interaction in the complex between beta- and gamma-subunits of transducin.

1990 • 74 citations

Desensitization of skate photoreceptors by bleaching and background light.

1982 • 59 citations

Interplay between hydroxylamine, metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes

1983 • 50 citations

Transducin interactions with rhodopsin. Evidence for positive cooperative behavior.

1987 • 48 citations

Hydrogen ion changes of rhodopsin I. Proton uptake during the metarhodopsin I478 metarhodopsin II308 reaction

1973 • 34 citations

[44] Determination of molecular species of rod outer segment phospholipids

1982 • 27 citations

Light and GTP dependence of transducin solubility in retinal rods

1988 • 27 citations

TRANSDUCIN ACTIVATION BY MOLECULAR SPECIES OF RHODOPSIN OTHER THAN METARHODOPSIN II*

1989 • 23 citations

High-pH form of bovine rhodopsin

1992 • 19 citations

Activation of phosphodiesterase by rhodopsin and its analogues

1983 • 18 citations

All-trans-retinoids and dihydroretinoids as probes of the role of chromophore structure in rhodopsin activation

1985 • 17 citations

Activation of phosphodiesterase in frog rod outer segment by rhodopsin analogues

1982 • 12 citations

The links between rhodopsin bleaching and visual adaptation

1982 • 9 citations

Coordination of cytidine to the Pd(II)-peptide complexes

1982 • 8 citations

Interaction of visual pigment with G-protein: Effects of bleaching in native and reconstituted ROS preparations

1987 • 5 citations