Ki-ras point mutations and proliferation activity in biliary tract carcinomas

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

SAMPLE PREPARATION FROM PARAFFIN-EMBEDDED TISSUES

1990 • 565 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.

1993 • 351 citations

Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.

1991 • 336 citations

Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma.A study of 57 autopsy-proven cases

1977 • 262 citations

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.

1991 • 210 citations

Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma.

1989 • 199 citations

Allele-specific polymerase chain reaction: A method for amplification and sequence determination of a single component among a mixture of sequence variants

1991 • 163 citations

Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing

1990 • 143 citations

Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: Relation to gross tumor morphology

1995 • 137 citations

Research into the results of resection of hilar bile duct cancer.

1990 • 134 citations

Frequency and Types of Point Mutation at the 12th Codon of the c‐Ki‐ras Gene Found in Pancreatic Cancers from Japanese Patients

1989 • 128 citations

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.

1992 • 123 citations

Distinguishing Pancreatic Carcinoma From Other Periampullary Carcinomas by Analysis of Mutations in the Kirsten-ras Oncogene

1991 • 109 citations

Inhibition of pancreatic adenocarcinoma cell growth by lovastatin

1992 • 109 citations

K‐ ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis

1994 • 96 citations

The assessment of proliferating cell nuclear antigen immunohistochemical staining in small hepatocellular carcinoma and its relationship to histologic characteristics and prognosis

1993 • 94 citations

Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.

1991 • 90 citations

Pancreatic cancer in europe: Ki‐ras gene mutation pattern shows geographical differences

1994 • 81 citations

K-ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis

1994 • 74 citations

Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosine.

1992 • 69 citations

Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst

1993 • 68 citations

Many Gene Changes Found in Cancer

1989 • 65 citations

Cholangiocarcinomas in japanese and thai patients: Difference in etiology and incidence of point mutation of the c-KI-ras proto-oncogene

1992 • 59 citations

K‐ras Gene Mutation in Early Ductal Lesions Induced in a Rapid Production Model for Pancreatic Carcinomas in Syrian Hamsters

1993 • 59 citations

Clinical characteristics and proliferating activity of intrahepatic cholangiocarcinoma

1994 • 48 citations

Methylation of hamster DNA by the carcinogen N-nitroso-bis (2-oxopropyl)amine

1981 • 42 citations

Choledochal cyst: Anomalous arrangement of the pancreaticobiliary ductal system and biliary malignancy

1989 • 33 citations

High Rates of Ki-<italic>ras</italic> Point Mutation in Both Intra- and Extra-hepatic Cholangiocarcinomas

1994 • 27 citations

DNA alkylation in the hamster induced by two pancreatic carcinogens.

1989 • 26 citations

Mutagenicity of the bile of dogs with an experimental model of an anomalous arrangement of the pancreaticobiliary duct

1993 • 18 citations

Hyperplasia, Adenoma, Gallbladder, Hamster

1985 • 2 citations