Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

ras GENES

1987 • 3,818 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

1983 • 2,066 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

THE PROGNOSTIC SIGNIFICANCE OF DIRECT EXTENSION OF CARCINOMA OF THE COLON AND RECTUM

1954 • 1,110 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction.

1988 • 748 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes.

1988 • 367 citations

Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer

1987 • 311 citations

A rapid single step staining technique for DNA analysis by flow microfluorimetry.

1980 • 294 citations

Chromosome mutation and neoplasia

1983 • 290 citations

The influence of tumour cell DNA abnormalities on survival in colorectal cancer

1985 • 281 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

Mutations in N-ras predominate in acute myeloid leukemia

1987 • 239 citations

Activated ras oncogenes in human thyroid cancers.

1988 • 233 citations

Progression to cancer in Barrett's esophagus is associated with genomic instability.

1989 • 225 citations

Genesis of Colorectal Cancer

1976 • 168 citations

Significance of the labeling index and labeling distribution as kinetic parameters in colorectal mucosa of cancer patients and DMH treated animals

1982 • 128 citations

Should Flow Cytometric DNA Analysis Precede Definitive Surgery for Colon Carcinoma?

1985 • 104 citations

Cell kinetic indicators of premalignant stages of colorectal cancer

1985 • 102 citations

PLOIDY AND PROLIFERATION PATTERNS IN COLO‐RECTAL ADENOCARCINOMAS RELATED TO DUKES‘ CLASSIFICATION AND TO HISTOPATHOLOGICAL DIFFERENTIATION

1983 • 100 citations

Biomarkers of Increased Susceptibility to Gastrointestinal Cancer

1987 • 75 citations

Activation of the K-ras protooncogene in lung tumors from rats and mice chronically exposed to tetranitromethane.

1987 • 72 citations

Is DNA aneuploidy a good prognostic indicator in patients with advanced colorectal cancer?

1986 • 71 citations

Activated H-ras oncogenes in human kidney tumors.

1988 • 62 citations

Three new restriction endonucleasesMaeI, MaeIIandMaeIIIfromMethanococcus aeolicus

1984 • 59 citations

Nucleotide sequence preservation of human leukemic mitochondrial DNA.

1985 • 37 citations