JNK Suppresses Apoptosis via Phosphorylation of the Proapoptotic Bcl-2 Family Protein BAD

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

How do 14‐3‐3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis

2001 • 659 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

2003 • 557 citations

Activation of the JNK signaling pathway: Breaking the brake on apoptosis

2002 • 432 citations

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1992 • 387 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH ₂ -terminal kinase

1997 • 382 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

2003 • 288 citations

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

2000 • 279 citations

JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

1999 • 272 citations

Bad Is a BH3 Domain-Containing Protein That Forms an Inactivating Dimer with Bcl-X_L

1997 • 271 citations

JNK Phosphorylation and Activation of BAD Couples the Stress-activated Signaling Pathway to the Cell Death Machinery

2002 • 244 citations

Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

2001 • 219 citations

Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts

2002 • 161 citations

The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells

1999 • 146 citations

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

2002 • 138 citations

Masters change, slaves remain

2002 • 132 citations

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

1997 • 120 citations

The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity

1999 • 110 citations

Blocking Caspase-3-Mediated Proteolysis of IKKβ Suppresses TNF-α-Induced Apoptosis

2001 • 107 citations

Cytokine-Induced Protein Kinase B Activation and Bad Phosphorylation Do Not Correlate with Cell Survival of Hemopoietic Cells

1999 • 91 citations

Errors of homeostasis and deregulated apoptosis

1997 • 53 citations

Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression.

2002 • 53 citations