Thermotolerance in Cultured Hepatoma Cells: Cell Viability, Cell Morphology, Protein Synthesis, and Heat-Shock Proteins

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Role of cell shape in growth control

1978 • 2,434 citations

Measurement of the incorporation of radioactive amino acids into protein by a filter-paper disk method

1961 • 2,062 citations

Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.

1982 • 754 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

Synthesis and degradation of heat shock proteins during development and decay of thermotolerance.

1982 • 433 citations

Heat fractionation and thermotolerance: a review.

1978 • 364 citations

Heat shock proteins and thermal resistance in yeast

1980 • 335 citations

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.

1964 • 314 citations

Regulation of protein synthesis in HeLa cells: Translation at elevated temperatures

1969 • 302 citations

Heat shock proteins and thermotolerance; a comparison of induction kinetics

1982 • 264 citations

Transient rates of synthesis of individual polypeptides in E. coli following temperature shifts

1978 • 257 citations

Specific protection from phenocopy induction by heat shock

1979 • 204 citations

The spatial distribution of polyribosomes in 3T3 cells and the associated assembly of proteins into the skeletal framework

1980 • 194 citations

Parallel changes in puffing activity and patterns of protein synthesis in salivary glands of Drosophila.

1975 • 184 citations

Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature

1978 • 181 citations

A response of protein synthesis to temperature shift in the yeast Saccharomyces cerevisiae.

1979 • 169 citations

Recovery of protein synthesis after heat shock: prior heat treatment affects the ability of cells to translate mRNA.

1981 • 167 citations

Modulation of heat shock polypeptide synthesis in HeLa cells during hyperthermia and recovery

1982 • 162 citations

A proposed operational model of thermotolerance based on effects of nutrients and the initial treatment temperature.

1980 • 160 citations

Arrhenius Analysis of Heat Survival Curves from Normal and Thermotolerant CHO Cells

1979 • 148 citations

The response of cells to heat shock

1982 • 139 citations

Effects of hyperthermia (45 degrees) on macromolecular synthesis in Chinese hamster ovary cells.

1979 • 117 citations

Induction of thermotolerance in Chinese hamster ovary cells by high (45 degrees) or low (40 degrees) hyperthermia.

1978 • 115 citations

Induced thermal tolerance and heat shock protein synthesis in Chinese hamster ovary cells

1982 • 100 citations

Cilia regeneration in starved tetrahymena: an inducible system for studying gene expression and organelle biogenesis

1979 • 91 citations

Thermotolerance and heat shock proteins induced by hyperthermia in rat liver cells

1982 • 82 citations

Lethality in Mammalian Cells Due to Hyperthermia under Oxic and Hypoxic Conditions

1978 • 79 citations

Modification of the Heat Response and Thermotolerance by Cycloheximide, Hydroxyurea, and Lucanthone in CHO Cells

1982 • 73 citations

Heat shock proteins and biological response to hyperthermia.

1982 • 60 citations

Hyperthermia and the heat-shock proteins of HeLa cells

1982 • 57 citations

Effects of heat shock on gene expression and subcellular protein distribution in Chinese hamster ovary cells

1979 • 52 citations

Induction of thermotolerance by multiple heat fractions in Chinese hamster ovary cells.

1979 • 41 citations

Effect of hyperthermia on protein biosynthesis in L5178Y murine leukemic lymphoblasts

1974 • 36 citations

Stimulation of enzyme synthesis and inhibition of DNA synthesis and growth rate by cyclic AMP derivatives in cultured hepatoma cells

1973 • 35 citations

The initiation and elongation steps in protein synthesis: Relative rates in chinese hamster ovary cells during and after hyperthermic and hypothermic shocks

1979 • 25 citations

Studies on the Posttranscriptional Site of cAMP Action in the Regulation of the Synthesis of Tyrosine Aminotransferase

1981 • 24 citations

A morphologic and morphometric study of the mitochondria in several hepatoma cell lines and in isolated hepatocytes

1978 • 18 citations

Initiation and elongation of protein synthesis: Their relative rates and sensitivities to inhibition in Chinese hamster ovary cells determined by a modified Edman procedure

1976 • 10 citations

Variations in some molecular events during the early phases of the reuber H 35 hepatoma cell cycle

1979 • 9 citations

Variations in some molecular events during the early phases of the Reuber H35 hepatoma cell cycle

1982 • 8 citations

Heat production of reuber H35 rat hepatoma cells under normo- and hyperthermia conditions

1982 • 7 citations

Positive and Negative cAMP‐Mediated Control of Tyrosine Aminotransferase Synthesis in Reuber H35 Hepatoma Cells

1982 • 5 citations