Prostacyclin and atherosclerosis

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

The Pathogenesis of Atherosclerosis

1976 • 2,000 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

The Pathogenesis of Atherosclerosis

1976 • 1,169 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Hyperlipidemia and Atherosclerosis

1976 • 746 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Purification of human platelet-derived growth factor.

1979 • 586 citations

Generation of prostacyclin by lungs in vivo and its release into the arterial circulation

1978 • 374 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits

1977 • 287 citations

SUCCESSFUL THERAPY OF ADVANCED ARTERIOSCLEROSIS OBLITERANS WITH PROSTACYCLIN

1979 • 279 citations

Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbits

1978 • 256 citations

FREE-RADICAL OXIDATION AND ANTIOXIDANTS

1978 • 234 citations

Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells.

1978 • 196 citations

Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men

1978 • 181 citations

Distribution of cadmium, zinc and copper in the musselMytilus edulis. Existence of cadmium-binding proteins similar to metallothioneins

1976 • 146 citations

Thromboxane Generation and Platelet Aggregation in Survivals of Myocardial Infarction

1978 • 125 citations

Modulation of human platelet function by prostacyclin and thromboxane A2.

1979 • 120 citations

Lipoproteins and the inhibitory effect of human endothelial cells on platelet function.

1978 • 110 citations

Experimental atherosclerosis in rabbits: Platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin

1977 • 97 citations

Prostacyclin as a circulatory hormone

1979 • 76 citations

Anti-platelet action of intravenous infusion of prostacyclin in man

1978 • 76 citations

Injury to cultured endothelial cells induced by low density lipoproteins: protection by high density lipoproteins

1979 • 60 citations

Inflammation: the role of peroxidase-derived products.

1980 • 54 citations

Lipoperoxide formation in the retina in ocular siderosis

1976 • 47 citations

Intermittent claudication and rest pain: Physiologic concepts and therapeutic approaches

1979 • 41 citations

The antithrombotic activity of BAY g 6575.

1979 • 38 citations

Atherosclerosis decreased prostacyclin formation in rabbit lungs and kidneys

1979 • 27 citations

Progression and Regression of Atherosclerosis : Symposium on Atherosclerosis; Its Progression and Regression

1980 • 26 citations

PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine

1979 • 22 citations

Prostacyclin activity in rat kidney stimulated by angiotensin II.

1979 • 21 citations

Endogenous Mechanisms which Regulate Prostacyclin Release

1979 • 18 citations

Bay g 6575, An Anti Thrombotic Compound that Stimulates Prostacyclin Release from the Vessel Wall

1979 • 13 citations

Diminished Prostacyclin Generation in Human and Experimentally Induced (Streptozotocin, Alloxan) Diabetes Mellitus

1979 • 7 citations

Early Changes of the Endothelial Antithrombotic Properties in Cholesterol Fed Rabbits. III-Decreased PGI2 Production by Aortic Wall

1979 • 6 citations