Protein Kinase Cα Activates c-Src and Induces Podosome Formation via AFAP-110

Role of Src expression and activation in human cancer

2000 • 832 citations

Src family kinases in tumor progression and metastasis.

2003 • 787 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

Src in cancer: deregulation and consequences for cell behaviour

2002 • 679 citations

Podosomes: adhesion hot-spots of invasive cells

2003 • 607 citations

Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes

1985 • 426 citations

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.

1989 • 349 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Protein kinase C phosphorylates pp60src at a novel site

1985 • 243 citations

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

2002 • 226 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

1999 • 192 citations

Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation

1999 • 148 citations

Protein Kinase C Induces Actin Reorganization via a Src- and Rho-dependent Pathway

2002 • 136 citations

Enhancement of Migration by Protein Kinase Cα and Inhibition of Proliferation and Cell Cycle Progression by Protein Kinase Cδ in Capillary Endothelial Cells

1997 • 134 citations

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.

1993 • 125 citations

Conventional Protein Kinase C Mediates Phorbol-Dibutyrate-Induced Cytoskeletal Remodeling in A7r5 Smooth Muscle Cells

2002 • 116 citations

Rho and Rab Small G Proteins Coordinately Reorganize Stress Fibers and Focal Adhesions in MDCK Cells

1998 • 106 citations

Transformation-Specific Tyrosine Phosphorylation of a Novel Cellular Protein in Chicken Cells Expressing Oncogenic Variants of the Avian Cellular src Gene

1989 • 95 citations

Protein Kinase Cδ Induces Src Kinase Activity via Activation of the Protein Tyrosine Phosphatase PTPα

2003 • 91 citations

Molecular mechanism of actin-dependent retograde flow in lamellipodia of motile cells

1997 • 89 citations

Protein Kinase C as a Drug Target Implications for Drug or Diet Prevention and Treatment of Cancer

2000 • 85 citations

Protein Kinase C Isozymes, Novel Phorbol Ester Receptors and Cancer Chemotherapy

2001 • 62 citations

Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion

1997 • 56 citations

The Sites of Phosphorylation by Protein Kinase C and an Intact SH2 Domain Are Required for the Enhanced Response to β-Adrenergic Agonists in Cells Overexpressing c-src

1993 • 54 citations

v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

1991 • 53 citations

Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity

1998 • 50 citations

Site-Specific Increased Phosphorylation of pp60 ^{v- src} After Treatment of RSV-Transformed Cells with a Tumor Promoter

1985 • 49 citations

The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src.

1997 • 48 citations

The Carboxy Terminus of AFAP-110 Modulates Direct Interactions with Actin Filaments and Regulates Its Ability to Alter Actin Filament Integrity and Induce Lamellipodia Formation

2000 • 48 citations

The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).

1999 • 47 citations

Increased protein kinase C alpha expression in human colonic Caco-2 cells after insertion of human Ha-ras or polyoma virus middle T oncogenes.

1993 • 47 citations

The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases

2001 • 46 citations

PKC Phosphorylation Increases the Ability of AFAP-110 to Cross-link Actin Filaments

2002 • 44 citations

pp60v-src association with the cytoskeleton induces actin reorganization without affecting polymerization status.

1990 • 42 citations

PKC-Dependent Activation of FAK and Src Induces Tyrosine Phosphorylation of Cas and Formation of Cas–Crk Complexes

2001 • 42 citations

Selective activation of protein kinase C isoforms by v-Src.

1995 • 40 citations

Cytoskeletal architecture in mouse lung epithelial cells is regulated by protein-kinase C-alpha and calpain II

1996 • 39 citations

Eps8, a Tyrosine Kinase Substrate, Is Recruited to the Cell Cortex and Dynamic F-Actin upon Cytoskeleton Remodeling

1998 • 32 citations

Identification and Sequence Analysis of cDNAs Encoding a 110-Kilodalton Actin Filament-Associated pp60^src Substrate

1993 • 30 citations

Formation of a stable src–AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif

1998 • 30 citations

The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes

2000 • 28 citations

Molecular cloning of actin filament-associated protein: a putative adaptor in stretch-induced Src activation

2002 • 27 citations

Analysis of the role of the leucine zipper motif in regulating the ability of AFAP‐110 to alter actin filament integrity

2003 • 23 citations

Differential Activation of Protein Kinase C Isozymes by Phorbol Ester and Collagen in Human Skin Microvascular Endothelial Cells

1996 • 18 citations

Localization of the viral and cellular Src kinases to perinuclear vesicles in fibroblasts.

1992 • 18 citations

Monoclonal Antibodies Directed Against AFAP-110 Recognize Species-Specific and Conserved Epitopes

1999 • 13 citations