Purification and characterization of cytosolic diacylglycerol kinases of human platelets.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Phospholipid Metabolism in Stimulated Human Platelets

1980 • 367 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Signal transduction via phosphatidylcholine cycles

1989 • 314 citations

Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin

1979 • 285 citations

R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.

1985 • 270 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Diacylglycerol kinase: a key modulator of signal transduction?

1990 • 189 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence.

1986 • 148 citations

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies.

1983 • 135 citations

Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets.

1986 • 134 citations

A membrane-bound diacylglycerol kinase that selectively phosphorylates arachidonoyl-diacylglycerol. Distinction from cytosolic diacylglycerol kinase and comparison with the membrane-bound enzyme from Escherichia coli.

1988 • 134 citations

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1989 • 123 citations

An early decrease in phosphatidylinositol turnover occurs on induction of friend cell differentiation and precedes the decrease in c-myc expression

1985 • 105 citations

Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts.

1988 • 94 citations

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

1988 • 90 citations

Regulation of diacylglycerol kinase reaction in Swiss 3T3 cells. Increased phosphorylation of endogenous diacylglycerol and decreased phosphorylation of didecanoylglycerol in response to platelet-derived growth factor.

1988 • 89 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Purification, reconstitution, and partial amino- and carboxyl-terminal analysis.

1985 • 84 citations

Properties of Microsomal and Soluble Diacylglycerol Kinase in Rat Liver

1978 • 81 citations

A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets

1987 • 79 citations

Immunological characterization of sn-1,2-diacylglycerol and sn-2-monoacylglycerol kinase from pig brain.

1986 • 70 citations

Diacylglycerol-induced translocation of diacylglycerol kinase: use of affinity-purified enzyme in a reconstitution system.

1986 • 70 citations

Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils.

1989 • 66 citations

Evidence that cyclic AMP may regulate Ca2+-mobilization and phospholipases in thrombin-stimulated human platelets

1983 • 55 citations

Translocation of diacylglycerol kinase in response to chemotactic peptide and phorbol ester in neutrophils

1987 • 54 citations

Immunoquantitation of 80 kDa diacylglycerol kinase in pig and human lymphocytes and several other cells

1989 • 54 citations

Phosphorylation of diacylglycerol kinase in vitro by protein kinase C

1989 • 53 citations

Phorbol ester-induced translocation of diacylglycerol kinase from the cytosol to the membrane in Swiss 3T3 fibroblasts

1989 • 50 citations

Signal Transmission in Exocrine Cells Is Associated with Rapid Activity Changes of Acyltransferases and Diacylglycerol Kinase Due to Reversible Protein Phosphorylation

1989 • 49 citations

Occurrence of immunoreactive 80 kDa and non-immunoreactive diacylglycerol kinases in different pig tissues.

1988 • 46 citations

Partial purification and properties of diacylglycerol kinase from rat liver cytosol

1981 • 43 citations

The diacylglycerol kinase inhibitor, R59022, enhances the superoxide generation from human neutrophils induced by stimulation of fMet-Leu-Phe, IgG and C3b receptors

1987 • 38 citations

Disappearance of diacylglycerol kinase translocation in ras-transformed cells

1988 • 32 citations

Utilization of diacylglycerol in phospholipid bilayers by pig brain diacylglycerol kinase and Rhizopus arrhizus lipase.

1984 • 31 citations

The diacylglycerol kinase inhibitor R 59022 potentiates bombesin stimulation of protein kinase C activity and DNA synthesis in swiss 3T3 cells

1988 • 29 citations

Regulation of diacylglycerol kinase in the transition from quiescence to proliferation in Dictyostelium discoideum

1988 • 16 citations

Increased protein synthesis response to insulin in fibroblasts treated with the diacylglycerol kinase inhibitor R59022

1988 • 8 citations