On mammary stem cells

Prospective identification of tumorigenic breast cancer cells

2003 • 10,067 citations

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Identification of human brain tumour initiating cells

2004 • 7,166 citations

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Identification of a cancer stem cell in human brain tumors.

2003 • 4,784 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

2003 • 2,344 citations

A role for Wnt signalling in self-renewal of haematopoietic stem cells

2003 • 2,131 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003

2000 • 1,352 citations

Tissue repair and stem cell renewal in carcinogenesis

2004 • 1,192 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

1997 • 1,116 citations

WNT Signals Are Required for the Initiation of Hair Follicle Development

2002 • 1,013 citations

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.

1959 • 985 citations

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

1994 • 969 citations

The Promise and Perils of Wnt Signaling Through β-Catenin

2002 • 959 citations

Wnt genes

1992 • 799 citations

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

2004 • 784 citations

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

2004 • 739 citations

Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

2003 • 695 citations

Self-Renewal and Cancer of the Gut: Two Sides of a Coin

2005 • 678 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

Stem cell origin of cancer and differentiation therapy

2004 • 628 citations

Intestinal stem cells protect their genome by selective segregation of template DNA strands

2002 • 621 citations

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

2001 • 542 citations

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

2004 • 532 citations

Sca-1pos Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population

2002 • 523 citations

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

2003 • 511 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Mammary ductal elongation: Differentiation of myoepithelium and basal lamina during branching morphogenesis

1983 • 453 citations

The hedgehog signaling network

2003 • 416 citations

Epidermal growth factor receptor inhibition strategies in oncology

2004 • 413 citations

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

2005 • 412 citations

An atlas of mouse mammary gland development.

2000 • 398 citations

The stem cell niche: theme and variations

2004 • 341 citations

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

2005 • 340 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Wnt Signaling and Breast Cancer

2004 • 331 citations

Diverse mechanisms regulate stem cell self-renewal

2004 • 330 citations

An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

2004 • 327 citations

A putative human breast stem cell population is enriched for steroid receptor-positive cells

2004 • 319 citations

The segregation of DNA in epithelial stem cells

1978 • 299 citations

Functional and molecular characterisation of mammary side population cells

2002 • 294 citations

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

2004 • 292 citations

Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands

2005 • 286 citations

Wnt Proteins in Mammary Development and Cancer

2004 • 244 citations

A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland

1988 • 233 citations

PTENless means more

2004 • 224 citations

Multiple niches for Notch in cancer: context is everything

2003 • 211 citations

Beta-catenin and Tcfs in mammary development and cancer.

2003 • 208 citations

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer

2004 • 207 citations

Signaling in stem cell niches: lessons from theDrosophilagermline

2005 • 195 citations

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

1997 • 194 citations

Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression

2004 • 191 citations

Growth and differentiation of progenitor/stem cells derived from the human mammary gland

2004 • 177 citations

Mammary epithelial stem cells

2001 • 177 citations

WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

2001 • 175 citations

Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors

2004 • 173 citations

Notch Signaling in Mammary Development and Oncogenesis

2004 • 163 citations

Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth

1998 • 156 citations

Epithelial Progenitors in the Normal Human Mammary Gland

2005 • 151 citations

Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1

1999 • 144 citations

Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development.

1995 • 98 citations

The Gli2 Transcription Factor Is Required for Normal Mouse Mammary Gland Development

2001 • 95 citations

A β-catenin survival signal is required for normal lobular development in the mammary gland

2003 • 92 citations

Epithelial Stem Cells and Their Niche: There's No Place Like Home

2005 • 77 citations

Differential Requirements for Shh in Mammary Tissue and Hair Follicle Morphogenesis

2002 • 56 citations

EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties

2002 • 50 citations

Multipotential stem cells and ‘side population’ cells

2002 • 44 citations

Expression of Ly-6, a marker for highly malignant murine tumor cells, is regulated by growth conditions and stress

1998 • 39 citations

Accelerated repopulation during fractionated irradiation of a murine ovarian carcinoma: Downregulation of apoptosis as a possible mechanism

1996 • 38 citations

Hedgehog Signaling in Animal Development and Human Disease

2000 • 11 citations